Lung Cancer in HIV-Infected Patients: The Experience of an Urban Clinic

Ruiz, Marco

doi:10.1177/1545109710373279

Cited by 13 publications

(13 citation statements)

References 19 publications

(29 reference statements)

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“…14,40,[54][55][56][57][58][59][60] With the exception of two retrospective studies, squamous cell cancer is the second commonest histological type (19-36%) in HIV-lung cancer patients, comparable to the 25% squamous cell cancer reported in HIV indeterminate individuals in the SEER data set. 49,53 The predominance of adenocarcinoma among HIVinfected individuals mirrors the changes in the distribution of the histological types of lung cancer seen in the general population.…”

Section: Pathological Findingsmentioning

confidence: 62%

“…40,[52][53][54][55][56][57][58][59][60][61][62] Yet, in a recent registry linkage study, the difference in the age at diagnosis of lung cancer was relatively modest between persons with AIDS and the general population (50 vs. 54 years) after adjusting for the underlying population structures. 31 In HIV-infected patients with lung cancer, men are significantly overrepresented compared to women, with a male-female sex ratio of 5-10:1.…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…However, in the most recent of studies performed later in the HAART era, these two groups appear to have comparable survival times. 40,58,74 In a recent retrospective review of 75 patients with HIV-associated lung cancer, the median survival of those with advanced cancer was 9 months and was similar to the median survival of SEER lung cancer participants. 40 The direct influence of HAART on survival remains unanswered, although encouraging findings are emerging.…”

Section: Treatment and Outcomementioning

confidence: 99%

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Lung Cancer in HIV Infection

Mani

Aboulafia

2014

Cancers in People With HIV and AIDS

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Lung cancer is the most prevalent non-AIDS-defining malignancy in the HAART era. Smoking plays a significant role in the development of HIV-associated lung cancer, but the cancer risk is 2-4 times greater in HIV-infected persons than in the general population, even after adjusting for smoking intensity and duration. Lung cancer is typically diagnosed a decade or more earlier among HIV-infected persons (mean age, 46 years) compared to those without HIV infection. Adenocarcinoma is the commonest histological subtype, and the majority of patients are diagnosed with locally advanced or metastatic carcinoma. Since pulmonary infections are common among HIV-infected individuals, clinicians may not suspect lung cancer in this younger patient population. Surgery with curative intent remains the treatment of choice for early stage disease. Although there is increasing experience in using radiation and chemotherapy for HIV-infected patients who do not have surgical options, there is a need for prospective studies for this population frequently excluded from participating in cancer trials. Evidence-based treatments for smoking-cessation with demonstrated efficacy in the general population must be routinely incorporated into the care of HIV-positive smokers.

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Section: Pathological Findingsmentioning

confidence: 62%

Section: Clinical Characteristicsmentioning

confidence: 99%

Section: Treatment and Outcomementioning

confidence: 99%

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Lung Cancer in HIV Infection

Mani

Aboulafia

2014

Cancers in People With HIV and AIDS

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“…Both HIV-1 and HIV-2 have been associated with an increased risk of cervical cancer [42]; moreover, Burkitt lymphoma is a highly aggressive tumor that contains one of the cancer subtypes highly affecting HIV-infected patients [40,43]. Current studies suggest that lung cancer risk is higher in HIV-infected patients than in uninfected persons [44,45]. It is important to note that although Hodgkin's lymphoma has been repeatedly associated with AIDS, the Centers of Disease Control and Prevention (CDC) do not consider it as an AIDSdefining illness [42,46].…”

Section: Retroviruses-related Cancermentioning

confidence: 92%

Tumorigenesis related to retroviral infections

Braoudaki

Tzortzatou‐Stathopoulou

2011

J Infect Dev Ctries

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Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent. This report discusses the most established oncogenic retroviruses, including human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-1 and -2), Rous sarcoma virus (RSV), Abelson murine leukemia virus (A-MuLV), Moloney murine leukemia virus (M-MuLV), murine mammary tumor virus (MMTV), bovine leukemia virus, (BLV), Jaagsiekte sheep retrovirus (JSRV), and Friend spleen focus-forming virus (SFFV). The role of retroviruses as inducers of carcinogenesis, the mechanisms underlying oncogenic transformation, and the routes of transmission of several cancer-related retroviral infections are also described. Finally, the impact of cancer-related retroviral infections in the developing world is addressed. This review is an update of carcinogenesis caused by retroviral infections.

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“…These 2 findings are in positive correlation with the findings from other reports. [13][14][15][16][17][18][19] The role of immunosuppression has not been clearly defined. The results of our study suggest that immunosuppression may not play a role in lung cancer development.…”

Section: Lung Cancermentioning

confidence: 99%

Non-AIDS–Defining Cancers in New Orleans

Ruiz¹,

Johnson

Reske³

et al. 2013

J Int Assoc Provid AIDS Care

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Background: Non-AIDS-defining cancers in HIV-infected patients in the highly active antiretroviral therapy era have increased. To our knowledge a comprehensive review of non-AIDS-related malignancies in New Orleans has not yet been conducted. Methods: Databases from main institutions in New Orleans were queried retrospectively for the years 2001 to 2011. The International Classification of Diseases, Ninth Revision codes were used to search for HIV infection and cancer comorbidity. Results: A total of 16 patients were diagnosed with lung cancer (mean age 50 years) with 81% of the patients presenting with advanced stages. In all, 20 (mean age 47 years) were diagnosed with anal cancer, and 35% presented in late stages. In all, 14 patients (mean age 42 years) were diagnosed with Hodgkin Lymphoma, and 64% were diagnosed at late stage. A total of 5 women (mean age 44 years) were diagnosed with breast cancer with 40% of them presenting at late stage. Conclusion: Malignancies were diagnosed at late stages in the majority of the cases, presented with worse outcomes, and had higher recurrence rates. The role of HIV and other viruses (Epstein Barr virus, human papillomavirus) and the potential mechanisms or pathways of oncogene activation also need to be clarified.

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Lung Cancer in HIV-Infected Patients: The Experience of an Urban Clinic

Cited by 13 publications

References 19 publications

Lung Cancer in HIV Infection

Lung Cancer in HIV Infection

Tumorigenesis related to retroviral infections

Non-AIDS–Defining Cancers in New Orleans

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