Lung Cancer in Chronic Obstructive Pulmonary Disease

Raviv, Stacy; Hawkins, Keenan A.; DeCamp, Malcolm M.; Kalhan, Ravi

doi:10.1164/rccm.201008-1274ci

Cited by 97 publications

(84 citation statements)

References 107 publications

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“…The condition is also recognized as a systemic inflammatory disorder with numerous pulmonary and extra-pulmonary manifestations [64]. This may indicate that reduced overall survival in COPD patients may be related to systemic effects rather than to low lung function per se.…”

Section: Discussion Of Main Resultsmentioning

confidence: 99%

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

Bugge

Lund

Brunborg

et al. 2016

The Annals of Thoracic Surgery

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Section: Discussion Of Main Resultsmentioning

confidence: 99%

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

Bugge

Lund

Brunborg

et al. 2016

The Annals of Thoracic Surgery

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“…Chronic inflammation associated with COPD has been linked to the pathogenesis of lung cancer [44,45]. Epidemiologic studies indicate that COPD is one of the most important risk factors for lung cancer among cigarette smokers and precedes lung cancer in most cases.…”

Section: Chronic Pulmonary Inflammation and Cancermentioning

confidence: 99%

“…A more pronounced inflammatory response was observed in patients with COPD compared with smokers without COPD [47]. This response is characterized by epithelial injury, high cell turnover rates, and propagation of DNA errors [45]. Studies indicate that the inflammatory repair and remodeling processes promote epithelial-mesenchymal transition and lung carcinoma through excessive release of MMPs and growth factors.…”

Section: Chronic Pulmonary Inflammation and Cancermentioning

confidence: 99%

YKL-40/CHI3L1 drives inflammation on the road of tumor progression

Libreros

Iragavarapu-Charyulu

2015

Journal of Leukocyte Biology

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Inflammation plays a vital role at different stages of tumor progression. The development of tumors is affected by inflammatory mediators produced by the tumor and the host. YKL-40/chitinase-3-like-1 protein is often upregulated in inflammation-associated diseases. With the use of chronic inflammatory disease systems, we describe the role of YKL-40/chitinase-3-like-1 protein in enhancing the inflammatory response and its implications in tumorigenesis. We also discuss how pre-existing inflammation enhances tumor growth and metastasis. In this mini-review, we highlight the effect of YKL-40/ chitinase-3-like-1 protein-associated inflammation in promoting tumor progression. J. Leukoc. Biol. 98: 931-936;

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“…Chronic inflammation associated with COPD likely plays a role in the pathogenesis of lung cancer, and acute exacerbation can be the critical factor in the tumorigenesis of lung cancer. Inflammation in AECOPD may result in repeated airway epithelial injury, accompanying high cell turnover rates and propagation of DNA errors and resulting in amplification of the carcinogenic effects (Raviv et al 2011).…”

mentioning

confidence: 99%

New biomarkers and therapeutics can be discovered during COPD-lung cancer transition

Wang

2016

Cell Biol Toxicol

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Chronic obstructive pulmonary disease (COPD) has been found to be associated with lung cancer regardless of a patient's smoking history. Of 11,888 incident cases of lung cancer, 23 % had a prior diagnosis of COPD compared with only 6 % of the 37,605 controls (Powell et al. 2013). The prevalence of COPD in lung cancer patients varies from 8 to 50 %, and the annual incidence of lung cancer arising from COPD is 0.8-1.2 %. This indicates that ∼1 % of COPD patients develop lung cancer each year, while only 0.2 % of patients with normal pulmonary function develop lung cancer. The Environment and Genetics in a Lung Cancer Etiology population-based case-control study showed that lung cancer risk was increased among individuals with chronic bronchitis, emphysema, and COPD (Sekine et al. 2012). COPD co-exists with 40-70 % of lung cancer patients, and 50 % of newly diagnosed lung cancer patients had COPD whereas only 8 % of smokers without lung cancer had COPD. Smokers with COPD are more susceptible to lung cancer.Epidemiological studies indicate that tobacco smoke exposure accounts for nearly 90 % of cases of COPD and lung cancer. However, genetic factors may explain why 10-30 % of smokers develop to COPD, even though genetic network and gene set enrichment in cigarette smoking were found to be correlated with the development of lung cancer (Fang et al. 2013). COPD is closely linked to susceptibility to lung cancer and acts as the most important risk factor for lung cancer among smokers, predating lung cancer in up to 80 % of cases. Genome-wide association studies on lung cancer, lung function, and COPD have identified a number of overlapping Bsusceptibility^loci. With stringent phenotyping, several overlapping loci are independently associated with both COPD and lung cancer, but with pulmonary inflammation and apoptotic processes mediated by the bronchial epithelium (Bondarczuk and PiotrowskaSeget 2013;Corbel et al. 2002;Bao et al. 2016a). Some lung cancer-specific genetic variants were identified as BCOPD-related^genetic variants associated with clinical variables (Young et al. 2011).Gene and protein expression profiles were initially investigated among patients with stable COPD, acute exacerbation of COPD (AECOPD), COPD with or without smoking, and COPD with or without lung cancer, to compare with those of healthy or health smokers (Chen et al. 2012). A number of disease-, stage-, duration-, or therapy-specific biomarkers were selected to screen susceptible populations of COPD or lung cancer. Using clinical bioinformatic techniques, the specificity, biological function, or prevalence of selected target genes or proteins from patients with AECOPD were furthermore validated in association with different types, survival rate, or potential mechanism of lung cancer (Ye et al. 2015). Chronic inflammation associated with COPD likely plays a role in the pathogenesis of lung cancer, and acute exacerbation can be the critical factor in the tumorigenesis of lung cancer. Inflammation

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Lung Cancer in Chronic Obstructive Pulmonary Disease

Cited by 97 publications

References 107 publications

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

YKL-40/CHI3L1 drives inflammation on the road of tumor progression

New biomarkers and therapeutics can be discovered during COPD-lung cancer transition

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