Lung Cancer in China

She, Jun; Yang, Ping; Hong, Qunying; Bai, Chunxue

doi:10.1378/chest.11-2948

Cited by 243 publications

(108 citation statements)

References 27 publications

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“…Researchers have come to a consensus that lung cancer is the leading cause of cancer death not only in China but also worldwide [3]. Lung cancers can be classified into small-cell lung cancers and non-small-cell lung cancers (NSCLC) [4].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

Cao

Zhao

et al. 2017

Cell Physiol Biochem

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Aim: The contribution of the inflammatory mediator interleukin-17 (IL-17) in nonsmall cell lung cancer (NSCLC) malignancy has been reported in the literature. MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level. Our study aimed to investigate the interaction between IL-17 and miR-181a-5p in NSCLC. Methods: 35 patients with NSCLC and 24 COPD controls were selected and examined in our study. In vitro, H226 and H460 cell lines were exposed to different doses (20, 40, 60, and 80 ng/mL) of IL-17 to examine the effect of IL-17 on miR-181a-5p and vascular cell adhesion molecule 1 (VCAM-1) expression. MiR-181 mimic and miR-181a-5p inhibitor were transfected to explore the regulation of VCAM-1 as well as tumor cell proliferation and migration. Results: miR-181a-5p expression was downregulated, and IL-17 and VCAM-1 expression was upregulated in NSCLC tissues. Furthermore, IL-17 decreased miR-181a-5p expression but increased VCAM-1 expression in H226 and H460 cells. MiR-181 regulated VCAM-1 expression through binding to 3’-UTR sequence. MiR-181 attenuated tumor cell proliferation and migration. IL-17 modulated miR-181a-5p expression through activating NF-κB but not Stat3. Conclusion: Taken together, our data show the regulation of VCAM-1 expression by miR-181a-5p under IL-17 exposure, predicting a potential way for counteracting cancer metastasis.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

Cao

Zhao

et al. 2017

Cell Physiol Biochem

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“…In most Western countries, lung cancer incidence and mortality rates have been decreasing; in the United States (US), lung cancer incidence significantly decreased among men, although it remained stable among women during 2004–2009 1. In contrast, lung cancer incidence and mortality rates are still increasing in China 1, 2, 3…”

Section: Introductionmentioning

confidence: 99%

Lung cancer burden has increased during the last 40 years in Hebei Province, China

Song

et al. 2016

Thoracic Cancer

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BackgroundIn 2011, Hebei Province, located in North China with a population of 71 794 239, accounted for approximately 6% of the national population. It is well known as a heavily air polluted area. This study reports the lung cancer burden and mortality trend in Hebei Province from 1973 to 2011.MethodsEight cancer registries in Hebei Province submitted data to the Hebei Provincial Cancer Registry Center. Pooled data were stratified by area (urban/rural), gender, and age group. The proportions, cumulative incidence/mortality rates, and median age at death of lung cancer were calculated. Lung cancer mortality data of 1973–1975, 1990–1992, and 2004–2005 were extracted from national death surveys. Data of lung cancer from Cixian and Shexian were obtained from population‐based cancer registries in each county.ResultsThe estimated numbers of newly diagnosed lung cancer cases and deaths in 2011 in Hebei Province were 32 623 and 27 612, respectively. The crude incidence rate of lung cancer was 45.44/100 000. The age‐standardized incidence rate by world standard population was 39.01/100 000, ranking second among all cancers. The lung cancer mortality rate was 38.46/100 000, ranking first among all cancer deaths, with a significantly increasing trend in Hebei Province from 1973–1975 to 2010–2011, with an increased rate of 189.15%.Conclusion Hebei Province suffers a heavy disease burden of lung cancer and an obvious increasing trend has been observed over the past 40 years. Preventive and control strategies should be encouraged.

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“…Of notable concern in China, lung cancer mortality rate has continuously risen for the past three decades at an alarming annual rate of 464%. This has now replaced liver cancer as the leading cause of death from malignant tumors [2]. Therefore, understanding the causes of lung cancer is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Clinical End-Points Associated withMycobacterium tuberculosisand Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution

Tian

Hao

Cao

et al. 2015

BioMed Research International

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There is a recent emerging theory that suggests a cross-link between pathogens and cancer. In this context, we examined the association between the Mycobacterium tuberculosis (MTB) with its L-forms (MTB-L) and lung cancer. In the present study, we have optimized and applied a highly sensitive assay to detect the presence of MTB and MTB-L in 187 lung cancer samples and 39 samples of other cancer origins. By carefully controlling confounding factors, we have found that 62% of the lung cancer samples are MTB-L positive, while only 5.1% of the other cancer samples are MTB-L positive. Through generalized linear models and random forest models, we have further identified a set of clinical end-points that are strongly associated with MTB-L presence. Our finding provides the basis for future studies to investigate the underlying mechanism linking MTB-L infection to lung cancer development.

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Lung Cancer in China

Cited by 243 publications

References 27 publications

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1

Lung cancer burden has increased during the last 40 years in Hebei Province, China

Clinical End-Points Associated withMycobacterium tuberculosisand Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution

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