Lung cancer gender differences: An analysis of 1599 patients diagnosed between 1996 and 2018.

Abstract

e13596 Background: Several studies showed disparities in terms of gender in lung cancer pattern. As we know, there is limited available data from lung cancer trends by gender in Iran and information reported in previous Iranian studies has become outdated. Methods: This observational study included data of Lung Cancer which were obtained from National Institute of Tuberculosis and Lung Disease (NRITLD), Masih Daneshvari Hospital,from January 1, 1996 to June 1, 2018. Overall survival (OS) and progression free survival (PFS) were estimated for each gender at several time points by the Kaplan-Meier method. Results: Characteristics of 1599 patients are shown in Table. Adenocarcinoma was most prevalent pathology in both sex and incidence of this histology increased in men during all study periods except 2002-2006. Notably, Adenocarcinoma has an increasing pattern especially after 2006 in women. Most prevalent Stage was advanced stages in both sex. Mean OS were 9.84±0.56 and 10.27±0.91 months in male and female respectively (P = 0.769). Also, mean PFS was non-significantly longer in men than women (7.6±0.49 vs 7.4±0.39, P = 0.903).Cox regression multivariate analysis showed only significant effect for advanced/extensive stages on OS(P = 0.015). Conclusions: The findings highlight important characteristics of the lung cancer epidemic; women are diagnosed at younger age and were less smoker than men. It is necessary for all chealthcare systems to assess the cancer burden periodically and gender differences should be considered for screening guidelines, preventive strategies, and Treatment. [Table: see text]