Lung Cancer Following Chemotherapy and Radiotherapy for Hodgkin's Disease

Abstract

Past treatments with alkylating agents and radiation therapy for Hodgkin's disease were associated with an increased risk of lung cancer in a dose-dependent and additive fashion. The precise risk estimates, however, should be interpreted cautiously, given the possible residual and enhancing effects of tobacco.

Synchronous Triple Lung Cancers after Treatment for Non-Hodgkin's Lymphoma: Metachronous Quadruple Cancers

“…The triple lung cancers in the present patient developed over the course of a year, during treatment for malignant lymphoma after initial diagnosis. The period of one year was quite short, but it was compatible with the second report, above (5). To the best of our knowledge, however, double second lung cancers after malignant lymphoma had not been reported before, nor have synchronous triple lung cancers.…”

Minimization of radiation exposure due to computed tomography in inflammatory bowel disease

“…In general, protracted exposures to the same total dose of X-radiation are associated with lower risks than those of an acute exposure, both for cancer and other endpoints [12]. Latency of cancer induction due to ionizing radiation exposure is well recognized, and available evidence indicates that the time from exposure to incidence of cancer for solid tumors is at least 5 years and more commonly 10-20 years [13].…”

The Management of Patients with Limited-Stage Classical Hodgkin Lymphoma

“…Newer studies of late effects characterized the risk further. [23][24][25][26][27][28] We now know that thoracic radiation in women treated under the age of 30 years results in a very high rate of breast cancer that approximates 30% at 30 years following treatment 25 but that this risk is much lower in women who received alkylating agent chemotherapy with no hormone replacement therapy. 27 We also know that heavy smokers after thoracic radiation for Hodgkin lymphoma have a 20 times higher risk of lung cancers while light or nonsmokers have a 7 times higher risk.…”

“…27 We also know that heavy smokers after thoracic radiation for Hodgkin lymphoma have a 20 times higher risk of lung cancers while light or nonsmokers have a 7 times higher risk. 28 The dose and volume of radiation increase these risks, and newer treatment protocols that use lower radiation doses and reduced volumes should reduce the risk of second cancers. 29 Late effects of MOPP chemotherapy have been well characterized.…”