Lung cancer diagnosis by trained dogs†

Montes, Angela Guirao; López-Rodó, Laureano Molins; Rodriguez, I.; Dequigiovanni, Gemma Sunyer; Segarra, Núria; Sicart, Ramón María Marrades; Ferrández, Jorge Hernández; Alfara, Juan José Fibla; García-Navarro, Álvaro Agustí

doi:10.1093/ejcts/ezx152

Cited by 20 publications

(9 citation statements)

References 17 publications

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“…Cancer detection has received the most attention, with 2/3 of the studies targeting one or more cancers. 5 , 52 - 55 , 57 - 62 , 66 - 69 , 71 - 74 , 77 , 78 , 80 - 82 , 85 - 88 , 91 - 97 , 99 - 101 , 105 The remaining studies targeted tuberculosis, MRSA, 84 Malaria, 36 UTI, 79 Clostridium difficile , 63 , 70 , 83 , 89 , 98 and Covid 19 102 - 104 , 106 - 110 ( Figure 3 ). However, since the Covid-19 outbre...…”

Section: Resultsmentioning

confidence: 99%

“… 88 As well, some studies add information about fasting requirements before sampling, to limit biases (see Supplementary Table 2 , column Sampling protocol). 82 , 92 - 94 …”

Section: Resultsmentioning

confidence: 99%

“…Cancer detection has received the most attention, with 2/3 of the studies targeting one or more cancers. 5,52-55,57-62,66-69,71-74,77,78,80-82,85-88,91-97,99-101,105 The remaining studies targeted tuberculosis, MRSA, 84 Malaria, 36 UTI, 79 Clostridium difficile , 63,70,83,89,98 and Covid 19 102-104,106-110 (Figure 3). However, since the Covid-19 outbreak in 2020, already 8 original articles reporting the ability of dogs to detect Covid 19 have been published, and more will possibly follow.…”

Section: Resultsmentioning

confidence: 99%

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Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review

et al. 2022

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Background: Remote medical scent detection of cancer and infectious diseases with dogs and rats has been an increasing field of research these last 20 years. If validated, the possibility of implementing such a technique in the clinic raises many hopes. This systematic review was performed to determine the evidence and performance of such methods and assess their potential relevance in the clinic. Methods: Pubmed and Web of Science databases were independently searched based on PRISMA standards between 01/01/2000 and 01/05/2021. We included studies aiming at detecting cancers and infectious diseases affecting humans with dogs or rats. We excluded studies using other animals, studies aiming to detect agricultural diseases, diseases affecting animals, and others such as diabetes and neurodegenerative diseases. Only original articles were included. Data about patients’ selection, samples, animal characteristics, animal training, testing configurations, and performances were recorded. Results: A total of 62 studies were included. Sensitivity and specificity varied a lot among studies: While some publications report low sensitivities of 0.17 and specificities around 0.29, others achieve rates of 1 sensitivity and specificity. Only 6 studies were evaluated in a double-blind screening-like situation. In general, the risk of performance bias was high in most evaluated studies, and the quality of the evidence found was low. Conclusions: Medical detection using animals’ sense of smell lacks evidence and performances so far to be applied in the clinic. What odors the animals detect is not well understood. Further research should be conducted, focusing on patient selection, samples (choice of materials, standardization), and testing conditions. Interpolations of such results to free running detection (direct contact with humans) should be taken with extreme caution. Considering this synthesis, we discuss the challenges and highlight the excellent odor detection threshold exhibited by animals which represents a potential opportunity to develop an accessible and non-invasive method for disease detection.

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Section: Resultsmentioning

confidence: 99%

“… 88 As well, some studies add information about fasting requirements before sampling, to limit biases (see Supplementary Table 2 , column Sampling protocol). 82 , 92 - 94 …”

Section: Resultsmentioning

confidence: 99%

“…Cancer detection has received the most attention, with 2/3 of the studies targeting one or more cancers. 5,52-55,57-62,66-69,71-74,77,78,80-82,85-88,91-97,99-101,105 The remaining studies targeted tuberculosis, MRSA, 84 Malaria, 36 UTI, 79 Clostridium difficile , 63,70,83,89,98 and Covid 19 102-104,106-110 (Figure 3). However, since the Covid-19 outbreak in 2020, already 8 original articles reporting the ability of dogs to detect Covid 19 have been published, and more will possibly follow.…”

Section: Resultsmentioning

confidence: 99%

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Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review

et al. 2022

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“…For a few years now, medical professionals have been discussing the extent to which altered bodily odors can serve as an early indicator of a budding illness, including cancer. Dogs allegedly have a particularly refined ability to sense an onset of cancer (e.g., Guirao Montes et al, 2017; Yoel, Gopas, Ozer, Peleg, & Shvartzman, 2015). And surprisingly, it is precisely these animals with sensitive noses that do not react with disgust to the smell of serious mouth cancers.…”

Section: The Sense(s) Of An Emotionmentioning

confidence: 99%

The Odor of Disgust: Contemplating the Dark Side of 20th-Century Cancer History

Hitzer

2020

Emotion Review

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This article explores how historians of emotions and historians of the senses can collaborate to write a history of emotional experience that takes seriously the corporeality of emotions. It investigates how smell, feelings of disgust, and the moral judgments associated with these feelings were interrelated in 20th-century German cancer history. It demonstrates that this complex decisively shaped the emotional experiences of cancer patients. Uncovering this dynamic is only possible by conjoining the history of emotions with a more expanded version of the history of the senses. The combination reveals that the “odor of disgust” was not an ahistorical constant, but was, both in its parts and as a whole, subject to considerable shifts.

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“…Nevertheless, the 5-year survival rate after surgical resection of stage III patients is only 5–20% while stage I patients was up to 60–90%. Therefore, if proper methods for early-stage disease diagnosis can be found, especially by developing novel material-based breath sensor approaches with highly selective and ultrasensitive capabilities, − biomarker monitoring can be greatly improved. However, the screening of lung cancer breath biomarkers has still been a challenge because of the absence of unified sampling and analyzing methods, small sample size, and individual differences in patients.…”

Section: Introductionmentioning

confidence: 99%

Amine-Functionalized ZIF-8 as a Fluorescent Probe for Breath Volatile Organic Compound Biomarker Detection of Lung Cancer Patients

et al. 2020

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The highly thermally and chemically stable imidazole framework ZIF-8 samples were separately postmodified with amine groups by using N,N′-dimethylethylenediamine (MMEN) and N,N-dimethylaminoethylamine (MAEA), which had the same molecular formula but different structures. The modified ZIF-8 samples (ZIF-8@amine) were thoroughly characterized, including powder X-ray diffractometry, Fourier-transformed infrared spectroscopy, and physical adsorption at 77 K by nitrogen, thermogravimetric analysis, and photophysical characterization. Results showed that after modification, the Brunauer–Emmett–Teller surface area and total pore volume both increased, almost one time higher than those of the original ZIF-8 sample, and followed the order: ZIF-8-MMEN > ZIF-8-MAEA > ZIF-8. Furthermore, the N–H group was successfully grafted into the modified ZIF-8 samples. To examine the sensing properties of the modified ZIF-8@amine samples toward the breath biomarkers of lung cancer, five potential volatile organic compound biomarkers were used as analytes. ZIF-8-MMEN and ZIF-8-MAEA revealed a unique capacity for sensing hexanal, ethylbenzene, and 1-propanol with high efficiency and sensitivity. The three samples all did not show sensing ability toward styrene and isoprene. In addition, ZIF-8, ZIF-8-MMEN, and ZIF-8-MAEA all can sense hexanal with a detection limit as low as 1 ppb.

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Lung cancer diagnosis by trained dogs†

Abstract: This study shows that a well-trained dog can detect the presence of LC in exhaled gas samples with an extremely high accuracy.

Cited by 20 publications

References 17 publications

Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review

Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review

The Odor of Disgust: Contemplating the Dark Side of 20th-Century Cancer History

Amine-Functionalized ZIF-8 as a Fluorescent Probe for Breath Volatile Organic Compound Biomarker Detection of Lung Cancer Patients

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