Lung cancer biopsies: Comparison between simple 22G, 22G upgraded and 21G needle for EBUS-TBNA

Petridis, Dimitris; Sapalidis, Konstantinos; Tsakiridis, Kosmas; Baka, Sofia; Vagionas, Anastasios; Hohenforst-Schmidt, Wolfgang; Freitag, Lutz; Huang, Haidong; Bai, Chong; Drougas, Dimitris; Theofilatou, Vasiliki; Romanidis, Κonstantinos; Perdikouri, Εleni-Isidora; Petanidis, Savas; Zarić, Bojan; Kovačević, Tomi; Stojšić, Vladimir; Šarčev, Tatjana; Bursac, Daliborka; Kukić, Biljana; Perin, Branislav; Courcoutsakis, Nikolaos; Athanasiou, Evagelia; Hatzibougias, Dimitris; Drevelegas, Konstantinos; Boukovinas, Ioannis; Kosmidou, Maria; Kosmıdis, Christoforos

doi:10.7150/jca.48691

Cited by 11 publications

(16 citation statements)

References 31 publications

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“…Moreover; the issue method of administration, should be easy for the patient and without complication. EBUS-TBNA is a safe method under mild anesthesia and with small needles that do not cause any serious adverse effects 4 , 5 , 40 , 41 . We had to carefully choose which patients would benefit from this treatment modality and these patients would be two groups with endobronchial lesions and large parenchymal masses.…”

Section: Discussionmentioning

confidence: 99%

“…Data were first examined with descriptive statistics choosing frequencies for categorical variables and histograms for the continuous ones. Performance status (PS) was recorded in increasing order of deterioration grade (0, 1, 2) [27] and the disease progress (PG) in increasing order of health improvement (1,2,3,4) in accordance with the outcomes1 progression disease (PD), 2 stable disease (SD), 3 partial response (PR) and 4 complete response (CR). Patients were monitored 0, 4 and 8 months for PS and 4 and 8 months for PG.…”

Section: Statistical Materials and Methodsmentioning

confidence: 99%

“…Therefore lung cancer screening has been proposed for early disease diagnosis [1,2]. We have several different techniques and diagnostic tools for lung cancer diagnosis such as; ct guided biopsies, ultrasound transthoracic biopsies, endobronchial ultrasound EBUS-convex transbrochial biopsy needle aspiration (EBUS-TBNA), radial EBUS [3][4][5][6]. New novel navigation systems are also being used [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G

Hohenforst-Schmidt¹,

Huang²,

Zhou³

et al. 2021

J. Cancer

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Introduction: Immunotherapy is being used for the past five years either as first line or second line treatment with great results. Chemotherapy and radiotherapy have been also used as combination to immunotherapy to further enhance this type of treatment. Intratumoral treatment has been previously proposed as a treatment option for certain non-small cell lung cancer patients. Patients and Methods: We recruited in total seventy four patients with non-small cell lung cancer in their second line treatment who received only chemotherapy in their first line treatment with programmed death-ligand-1 ≤ 50. Only adenocarcinoma or squamous cell carcinoma, and all negative for epidermal growth factor receptor, anaplastic lymphoma kinase, proto-oncogene tyrosine-protein kinase-1 and proto-oncogene B-Raf. Data were first examined with descriptive statistics choosing frequencies for categorical variables and histograms for the continuous ones. Twenty five received only intravenous immunotherapy and forty-nine intravenous cisplatin with immunotherapy. Data were first examined with descriptive statistics choosing frequencies for categorical variables and histograms for the continuous ones.

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Section: Discussionmentioning

confidence: 99%

Section: Statistical Materials and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G

Hohenforst-Schmidt¹,

Huang²,

Zhou³

et al. 2021

J. Cancer

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“…Based on the findings, we administer either tyrosine kinase inhibitor (TKIS), immunotherapy, chemotherapy, or a combination of those drugs [ 6 , 8 ]. Tissue biopsies or cell-block biopsies provide us with efficient material in order to investigate all these genes and protein expressions [ 11 , 13 ]. Next-generation sequencing (NGS) is an efficient method that can identify simultaneously several genes, although it might take some days [ 6 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Radial-EBUS: CryoBiopsy Versus Conventional Biopsy: Time-Sample and C-Arm

Kosmıdis

Hohenforst-Schmidt

Matthaios

et al. 2022

IJERPH

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Introduction: Diagnosis of lung nodules is still under investigation. We use computed tomography scans and positron emission tomography in order to identify their origin. Patients and Methods: In our retrospective study, we included 248 patients with a single lung nodule or multiple lung nodules of size ≥1 cm. We used a radial-endobronchial ultrasound and a C-Arm. We used a 1.1 mm cryoprobe versus a 22G needle vs. forceps/brush. We compared the sample size of each biopsy method with the number of cell-block slices. Results: Central lesions indifferent to the method provided the same mean number of cell-block slices (0.04933–0.02410). Cryobiopsies provide less sample size for peripheral lesions due to the higher incidence of pneumothorax (0.04700–0.02296). Conclusion: The larger the lesion ≥2 cm, and central, more cell-blocks are produced indifferent to the biopsy method (0.13386–0.02939). The time of the procedure was observed to be less when the C-Arm was used as an additional navigation tool (0.14854–0.00089).

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“…Endoscopic methods during the past decade have been upgraded and new techniques such as the endobronchial ultrasound (EBUS) have enabled not only lung cancer diagnosis and staging, but also diagnosis of mediastinum lymphadenopathy [ 1 , 2 ]. The EBUS endoscope can use 22, 21 and 19G needles [ 3 , 4 ]. Cell blocks are being made from the biopsy samples and can provide us with the diagnosis for several diseases such as: sarcoidosis, tuberculosis (TB), lung cancer, lymphoma and metastasis from other cancer types to the thorax lymph nodes [ 5 ].…”

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confidence: 99%

Lymphadenopathy and Granulomas: Benignancy of Malignancy and Differential Diagnosis with Endobronchial Ultrasound-Transbronchial Needle Biopsy 19G Needle Fine-Needle Aspiration Biopsy

Hatzibougias¹,

Tsakiridis

Matthaios³

et al. 2021

Lung Cancer Manag.

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Endobronchial ultrasound (EBUS) is a very useful tool for the diagnosis of lymphadenopathy of the mediastinum. Nowadays, EBUS can substitute video-assisted thoracic surgery when a 19G needle is used. Several studies have provided data for efficient diagnosis not only for lung cancer, but for also sarcoidosis, tuberculosis and lymphoma. We present five cases of EBUS-transbronchial needle biopsy 19G needle used for the diagnosis of mediastinum lymphadenopathy. We present not only the pathological diagnosis, but also the steps for the differential clinical and pathological differential diagnosis for sarcoidosis, tuberculosis, cancer metastasis, respiratory infection and lymphoma.

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Lung cancer biopsies: Comparison between simple 22G, 22G upgraded and 21G needle for EBUS-TBNA

Cited by 11 publications

References 31 publications

Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G

Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G

Radial-EBUS: CryoBiopsy Versus Conventional Biopsy: Time-Sample and C-Arm

Lymphadenopathy and Granulomas: Benignancy of Malignancy and Differential Diagnosis with Endobronchial Ultrasound-Transbronchial Needle Biopsy 19G Needle Fine-Needle Aspiration Biopsy

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