Lung cancer and tobacco smoking in Crete, Greece: reflections from a population-based cancer registry from 1992 to 2013

Sifaki-Pistolla, Dimitra; Lionis, Christos; Georgoulias, Vassilis; Kyriakidis, Phaedon C.; Koinis, Filippos; Aggelaki, S.; Tzanakis, Nikos

doi:10.1186/s12971-017-0114-2

Cited by 12 publications

(21 citation statements)

References 36 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increasingly, reports are showing that cigarette smoking and alcohol consumption are risk factors for lung cancer 25 , 26 . Our results showed that the ratios of cigarette smokers/nonsmokers in controls (88.4:11.6) and patients with lung cancer (60.5:39.5) were relatively normal, similar to the ratios of alcohol consumption/no alcohol consumption in controls and patients.…”

Section: Discussionmentioning

confidence: 99%

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

Liu¹,

Yang²,

Chen³

et al. 2017

Int. J. Med. Sci.

View full text Add to dashboard Cite

Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer therapy. High-mobility group box 1 protein (HMGB1) is a ubiquitous nuclear protein found in eukaryotic cells that participates in several biological functions including immune response, cell survival, apoptosis and cancer development. We investigated the effects of HMGB1 gene polymorphisms on the risk of lung cancer progression in a Chinese Han population. Our sample of 751 participants included 372 patients with lung cancer and 379 healthy controls. Four single-nucleotide polymorphisms (SNPs) of the HMGB1 gene were examined by real-time polymerase chain reaction (RT-PCR). We found that the CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). The current study is the first to examine the risk factors associated with HMGB1 SNPs in lung cancer development in the Chinese Han population.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

Liu¹,

Yang²,

Chen³

et al. 2017

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Thus, tobacco prevention strategies should mainly target these smoking groups [67]. Generally, a shift towards less healthy behaviour was noticeable after the economic crisis, as has been observed in two recent Greek studies [72,73].…”

Section: Respiratory Mortality In Greece Amid An Economic Crisismentioning

confidence: 99%

Impact of the financial crisis on COPD burden: Greece as a case study

et al. 2018

View full text Add to dashboard Cite

Poverty and low socioeconomic status have been associated with chronic obstructive pulmonary disease (COPD). The current financial crisis has forced millions back into poverty. Greece is one of the countries hit the hardest, and is in the middle of a deep ongoing collapse. There have been early reports stating the apparent effects of the Greek downturn on respiratory health. This review summarises the overall impact of the financial crisis on COPD burden throughout the period of economic downturn by analysing the case study of Greece. In all levels of the healthcare system, current economic restrictions have reduced the capacity to prevent, diagnose and treat COPD in parallel with current higher detection rates of COPD. Remarkably, expenditure on healthcare has been reduced by >25%, resulting in major healthcare equipment shortages. Lower wages (by up to 20%) and higher co-payments of up to 25% of a drug's purchase price have led to patients struggling to afford inhaled medications. Treatment nonadherence has been reported, resulting in 11.5% more exacerbations and 14.1% more hospitalisations annually, while the mean cost per severe COPD exacerbation has been approximated as €2600. Greece is a noteworthy example illustrating how COPD burden, quality of care and patients' outcome can be affected by economic crisis.

show abstract

“…Linking relevant complementary data sources can expand availability and utility of data variables that can add additional context to investigations and evaluations of populations of patients with cancer. A few population-based registries in the United States 7,35,36 and outside the United States 8,9,11 have used patient medical records to more fully capture patients’ smoking status. Using this approach, information about smoking was captured for between 43% and 92% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Using this approach, information about smoking was captured for between 43% and 92% of patients. 7–9,11,36 Routinely abstracting information on smoking status from electronic medical records (EMRs) can be useful, even if the data are not complete. 8 However, depending on the EMR, this can require extensive time and effort.…”

Section: Discussionmentioning

confidence: 99%

“…Documenting smoking status at the time of a cancer diagnosis is important for helping patients with cancer who smoke quit, by assessing risks of multiple cancers and developing treatment and survivor care plans; and the availability of smoking status could further inform the investigation and/or evaluation of such, as has been demonstrated in a number of registries outside the United States. 8–11 Collection of smoking history for patients in cancer registries in the United States is nonstandardized, thus preventing large population-based studies from assessing the role of smoking on cancer treatment and outcomes. Cigarette smoking is harmful for people previously diagnosed with cancers, 12–15 and continued smoking negatively affects cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identifying Smoking Status and Smoking Cessation Using a Data Linkage Between the Kentucky Cancer Registry and Health Claims Data

Gallaway

Huang

Chen

et al. 2019

JCO Clinical Cancer Informatics

View full text Add to dashboard Cite

PURPOSE Linkage of cancer registry data with complementary data sources can be an informative way to expand what is known about patients and their treatment and improve delivery of care. The purpose of this study was to explore whether patient smoking status and smoking-cessation modalities data in the Kentucky Cancer Registry (KCR) could be augmented by linkage with health claims data. METHODS The KCR conducted a data linkage with health claims data from Medicare, Medicaid, state employee insurance, Humana, and Anthem. Smoking status was defined as documentation of personal history of tobacco use (International Classification of Diseases, Ninth Revision [ICD-9] code V15.82) or tobacco use disorder (ICD-9 305.1) before and after a cancer diagnosis. Use of smoking-cessation treatments before and after the cancer diagnosis was defined as documentation of smoking-cessation counseling (Healthcare Common Procedure Coding System codes 99406, 99407, G0375, and G0376) or pharmacotherapy (eg, nicotine replacement therapy, bupropion, varenicline). RESULTS From 2007 to 2011, among 23,703 patients in the KCR, we discerned a valid prediagnosis smoking status for 78%. KCR data only (72%), claims data only (6%), and a combination of both data sources (22%) were used to determine valid smoking status. Approximately 4% of patients with cancer identified as smokers (n = 11,968) and were provided smoking-cessation counseling, and 3% were prescribed pharmacotherapy for smoking cessation. CONCLUSION Augmenting KCR data with medical claims data increased capture of smoking status and use of smoking-cessation modalities. Cancer registries interested in exploring smoking status to influence treatment and research activities could consider a similar approach, particularly if their registry does not capture smoking status for a majority of patients.

show abstract

Lung cancer and tobacco smoking in Crete, Greece: reflections from a population-based cancer registry from 1992 to 2013

Cited by 12 publications

References 36 publications

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

Impact of the financial crisis on COPD burden: Greece as a case study

Identifying Smoking Status and Smoking Cessation Using a Data Linkage Between the Kentucky Cancer Registry and Health Claims Data

Contact Info

Product

Resources

About