Lung cancer and peritoneal carcinomatosis

Sereno, María; Rodríguez-Esteban, Isabel; Gómez-Raposo, César; Merino, María J.; López-Gómez, Miriam; Zambrana, Francisco; Casado, Enrique

doi:10.3892/ol.2013.1468

Cited by 25 publications

(18 citation statements)

References 10 publications

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“…All the cases of lung carcinoma (2.5%) which metastasised to ascitic fluid were adenocarcinomas which highlights the propensity of adenocarcinomas to cause malignant ascites in comparison to Squamous cell carcinoma. This finding is supported by the study done by Maria Sereno et al [16] in which > 80 % of malignant ascites were due to adenocarcinomas. Rarely, the source of malignant cell in ascitic fluid was found to be Squamous cell carcinoma of cervical origin (2%) and head and neck (1.5%) and urothelial carcinoma of bladder (1.5%).…”

Section: Discussionsupporting

confidence: 71%

Diagnosis of primary site of tumour origin using immunohistochemistry on cell block in cases of malignant ascitic fluid

Patel

Goel

Trivedi

et al. 2020

Trop J Pathol Microbiol

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Introduction:Presence of malignant cells in peritoneal fluid has serious implications as most of the times, it represents a metastasis from a distant organ, along with poor prognosis. Aim: 1) To ascertain primary site of origin from malignant ascitic fluid cases using cytoblock preparation and immunohistochemistry. 2) To find out frequency of various cancers from different parts of the body in malignant peritoneal fluid. Materials and methods: This is retrospective cross-sectional observation-based study in which 200 cases of malignant peritoneal fluid were studied and analysed. Routine clinical data, radiological investigations, histopathological diagnosis, cytomorphological features and immunohistochemistry were considered and statistically analysed. Results: 1) Malignant ascitic fluid cases are more common in older age group of patients and females outnumber the male patients substantially. 2) Adenocarcinoma is the most common histological type. 3) Ovary is the most common primary site of malignant peritoneal effusion. 4) Cytoblock preparation and immunohistochemistry on cytoblock can be very helpful in finding the primary site of origin in those cases where patients first presented to the hospital with signs of malignant ascites and no symptomatology related to primary site. Conclusion: Cytological examination of serous effusions is an accurate, prompt, affordable technique having diagnostic and therapeutic implications. With the help of ancillary methods, the phenotype of cells can be identified, classify as well as confirm our diagnosis.

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Section: Discussionsupporting

confidence: 71%

Diagnosis of primary site of tumour origin using immunohistochemistry on cell block in cases of malignant ascitic fluid

Patel

Goel

Trivedi

et al. 2020

Trop J Pathol Microbiol

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“…Surgical resection to remove the tumor together with surrounding lung tissue remains the best treatment for this disease. However, only 10-15% of patients are suitable for surgical resection (1). Cisplatin is the major component of the chemotherapeutic combination that is used in transcatheter arterial chemoembolization (cisplatinum, interferon, doxorubicin and 5-fluorouracil).…”

Section: Introductionmentioning

confidence: 99%

Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells

Gao

Liu

et al. 2014

Molecular Medicine Reports

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Abstract. Lung cancer is the primary malignancy of the lung and is the leading cause of cancer-associated mortality in China. Multidrug resistance (MDR) is an essential aspect of lung cancer treatment failure and a popular topic of investigation in tumor studies. Previous studies have demonstrated that soluble resistance-related calcium-binding protein (Sorcin) is involved in the MDR of various types of human tumor, and that silencing Sorcin was able to reverse the MDR of several types of cultured human cancer cells. However, the effect and potential mechanism underlying the ability of Sorcin to reverse MDR in human lung cancer remains to be fully elucidated. The present study examined the role of Sorcin in the reversal of MDR in human lung cancer A549/DDP cells. The effects included increased drug sensitivity to cisplatin, apoptotic rate, cell cycle arrest in the G2/M phase and intracellular accumulation of rhodamine-123, and decreased expression of multidrug resistance gene 1, lung resistance protein, multidrug resistance-associated protein, glutathione S-transferase π, ATP-binding cassette transporter A2 (ABCA2), ABCA5, B-cell lymphoma 2 and P-glycoprotein, and the depletion of glutathione in Sorcin-silenced A549/DDP cells. The present study also revealed that there was a downregulation of p-Akt and phosphorylated extracellular signal-regulated kinase (p-ERK), and a decreased transcriptional activation of nuclear factor κB, signal transducer and activator of transcription (STAT)3, STAT5 and nuclear factor of activated T-cells following silencing of Sorcin. The results indicated that Sorcin may be used as a potential therapeutic target for MDR through inhibiting the Akt and ERK pathways in human lung cancer.

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“…It has been suggested that oncogene status of the tumour can influence the patterns of metastatic spread 7. There are several case reports documenting association between EGFR-mutation and PC in the setting of primary lung cancer 10 11. In the study by Hsu and colleagues, all three identified patients with PC had EGFR-mutation including one patient with PC at the time of initial cancer diagnosis 11.…”

Section: Discussionmentioning

confidence: 99%

ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation

et al. 2020

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Peritoneal carcinomatosis (PC) is progression of the primary cancer to the peritoneum that is seen in only 1.2% of patients with lung cancer. It is associated with poor prognosis especially if present at the time of initial cancer diagnosis. The predisposing factors for peritoneal spread are not yet well understood. It has been suggested that the oncogene status of the tumour can influence the patterns of metastatic spread. There is not enough data about the role of c-ROS oncogene 1 (ROS1) mutation in the development of PC in non-small cell lung cancer. Here, we describe a case of a 56-year-old man who presented with new-onset ascites and was found to have PC. He was diagnosed with ROS1-rearranged lung adenocarcinoma. No obvious primary tumour was identified. Patient responded well to targeted therapy with crizotinib and remained 6 months free of disease progression.

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Lung cancer and peritoneal carcinomatosis

Cited by 25 publications

References 10 publications

Diagnosis of primary site of tumour origin using immunohistochemistry on cell block in cases of malignant ascitic fluid

Diagnosis of primary site of tumour origin using immunohistochemistry on cell block in cases of malignant ascitic fluid

Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells

ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation

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