Lung and myocardial thallium-201 kinetics in resting patients with congestive heart failure: Correlation with pulmonary capillary wedge pressure

Enhanced External Counterpulsation Reduces Lung/Heart Ratio at Stress in Patients with Coronary Artery Disease

“…Since LHR at stress correlates with LV diastolic volume and pressure [10], it is not surprising that the improvement of LHR at stress after EECP treatment did not accompany with a significant improvement of LVEF in this study.…”

“…In addition to the reversible and fixed perfusion defects of myocardium, the incremental value of lung/heart ratio (LHR) has been reported to reflect LV decompensation, which could be due to an increase in end-diastolic volume and pressure [9, 10]. Even in patients with normal LV systolic function and myocardial perfusion, elevated 201 Tl lung uptake, especially in response to stress, is a marker of elevated filling pressure which probably reflects LV diastolic dysfunction [11].…”

Thymic Lesions in Patients with Myasthenia Gravis: Characterization with Thallium 201 Scintigraphy

“…The entire lung on a 201 Tl SPECT section was used as a reference ROI in the quantitative evaluation, because the ROI setting on the entire lung was readily obtained and reproducible on the identical SPECT section of the thymic lesion. In the current investigation, no patients presented with symptoms of pulmonary disease or heart failure, which may cause 201 Tl uptake in the lung (30) and thereby result in an underestimation of the uptake ratio.…”

Clinical correlation between increased lung to heart ratio of tecnetium-99m sestamibi and multivessel coronary artery disease

“…In addition, increased lung uptake of Tl-201 is a predictor of adverse cardiac events and identifies a group of patients with poor prognosis [11,12]. Ventricular decompensation leading to increased left ventricular end diastolic pressure is thought to be the underlying mechanism behind the increased lung uptake in patients undergoing exercise myocardial perfusion imaging [6,8]. Increased wall stiffness from an increasing myocardial blood flow results in an elevated pulmonary capillary wedge pressure.…”

“…The number of vessels with significant CAD was recorded. Using visual estimation performed by three experienced angiographers, coronary disease was diagnosed in vessels with >50% obstruction of luminal diameter [1,6].…”