Lung abscess and pleuritis caused by Lactobacillus rhamnosus in an immunocompetent patient

Shoji, Hisashi; Yoshida, Koichiro; Niki, Yoshihito

doi:10.1007/s10156-009-0004-5

Cited by 14 publications

(15 citation statements)

References 11 publications

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“…It is thus possible that these organisms were misidentified and that, similar to what was observed in our study, L. rhamnosus and L. gasseri were more commonly isolated. The pathogenicity of L. rhamnosus has been confirmed by other reports (2,7,8,27), particularly in association with respiratory infections (28). In addition, the Gram staining of lactobacilli from the original specimen can be confusing; several of our specimens were interpreted as Gram-positive cocci in chains and possible rods.…”

Section: Discussionsupporting

confidence: 79%

Molecular Analysis and Clinical Significance of Lactobacillus spp. Recovered from Clinical Specimens Presumptively Associated with Disease

et al. 2014

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Veterans Administration Puget Sound Health Care System, Seattle, Washington, USA c Lactobacillus spp. are part of the normal human flora and are generally assumed to be nonpathogenic. We determined the genotypic identification of >100 Lactobacillus isolates from clinical specimens in the context of presumed pathogenic potential (e.g., recovered as the single/predominant isolate from a sterile site or at >10 5 CFU/ml from urine). This study assessed the clinical significance and the frequency of occurrence of each Lactobacillus sp. We identified 16 species of Lactobacillus by 16S rRNA gene sequence analysis, 10 of which could not be associated with disease. While Lactobacillus rhamnosus, Lactobacillus gasseri, and Lactobacillus paracasei were associated with infections, L. gasseri was also a common colonizing/contaminating species. Lactobacillus casei, Lactobacillus johnsonii, and Lactobacillus delbrueckii were associated with at least one infection. Species commonly used in probiotic products (e.g., L. rhamnosus and L. casei) were identical, by 16S rRNA gene sequencing, to our isolates associated with disease. Human isolates of Lactobacillus spp. have differing site associations and levels of clinical significance. Knowing the niche and pathogenic potential of each Lactobacillus sp. can be of importance to both clinical microbiology and the food and probiotic supplement industry.

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Section: Discussionsupporting

confidence: 79%

Molecular Analysis and Clinical Significance of Lactobacillus spp. Recovered from Clinical Specimens Presumptively Associated with Disease

et al. 2014

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“…Lactobacillus rhamnosus can be introduced into the GI tract through the consumption of yogurt and other dairy products (23). Even though it is beneficial in most cases, it has also been associated with endocarditis (24), pulmonary abscess, and pleuritis (25). Lactobacillus casei was found to have a protective role in the lung of a mouse model during Streptococcus pneumoniae infection (26).…”

Section: Discussionmentioning

confidence: 99%

Clinical Insights from Metagenomic Analysis of Sputum Samples from Patients with Cystic Fibrosis

et al. 2014

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f As DNA sequencing becomes faster and cheaper, genomics-based approaches are being explored for their use in personalized diagnoses and treatments. Here, we provide a proof of principle for disease monitoring using personal metagenomic sequencing and traditional clinical microbiology by focusing on three adults with cystic fibrosis (CF). The CF lung is a dynamic environment that hosts a complex ecosystem composed of bacteria, viruses, and fungi that can vary in space and time. Not surprisingly, the microbiome data from the induced sputum samples we collected revealed a significant amount of species diversity not seen in routine clinical laboratory cultures. The relative abundances of several species changed as clinical treatment was altered, enabling the identification of the climax and attack communities that were proposed in an earlier work. All patient microbiomes encoded a diversity of mechanisms to resist antibiotics, consistent with the characteristics of multidrug-resistant microbial communities that are commonly observed in CF patients. The metabolic potentials of these communities differed by the health status and recovery route of each patient. Thus, this pilot study provides an example of how metagenomic data might be used with clinical assessments for the development of treatments tailored to individual patients.

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“…4 In fact, Shoji et al from Japan have reported the only prior case of parapneumonic pleural space infection attributable to Lactobacilli. 2 In our patient, there was no evidence of interruption of the mucosal barrier, malignancy, or significant immunosuppression. Although a hemoglobin A1c percentage was not available, his elevated serum glucose level on presentation likely represented a stress response, and he was not known to require insulin.…”

Section: Discussionmentioning

confidence: 90%

Lactobacillus Empyema in a Patient With Schizophrenia

Staroselsky

Awerbuch

Galperin

et al. 2015

PLEURA

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Lactobacillus species are anaerobic gram-positive rods that are part of the normal human flora as well as commercially available probiotic formulations. Although their pathogenicity in the normal host has been the subject of debate, lactobacilli have been associated with serious infections in immunosuppressed patients and those with predisposing risk factors. We report a case of a patient with a history of schizophrenia who presented with an empyema, cultures of which identified Lactobacillus acidophilus and Lactobacillus rhamnosus as the causative organisms. To our knowledge, this is the first case of Lactobacillus parapneumonic pleural space infection reported from the Western Hemisphere.

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Lung abscess and pleuritis caused by Lactobacillus rhamnosus in an immunocompetent patient

Cited by 14 publications

References 11 publications

Molecular Analysis and Clinical Significance of Lactobacillus spp. Recovered from Clinical Specimens Presumptively Associated with Disease

Molecular Analysis and Clinical Significance of Lactobacillus spp. Recovered from Clinical Specimens Presumptively Associated with Disease

Clinical Insights from Metagenomic Analysis of Sputum Samples from Patients with Cystic Fibrosis

Lactobacillus Empyema in a Patient With Schizophrenia

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