Luminescent Rare-earth-based Nanoparticles: A Summarized Overview of their Synthesis, Functionalization, and Applications

Escudero, Alberto; Carrillo‐Carrión, Carolina; Zyuzin, Mikhail V.; Parak, Wolfgang J.

doi:10.1007/978-3-319-51192-4_5

Cited by 6 publications

(8 citation statements)

References 77 publications

(93 reference statements)

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“…More details on creation of nanoparticles are given in the Supporting Information . According to previous measurements, the fabricated Si particles have a crystalline structure 37 , 38 , as well as the YVO 4 particles 39 , 40 . The hydrodynamic diameters of the particles were d h (Si) = 170 ± 16 nm, d h (Au) = 150 ± 5 nm, d h (YVO 4 ) = 150 ± 7 nm, as determined in Milli-Q water with dynamic light scattering (DLS, see Table SI in the Supporting Information ).…”

Section: Resultsmentioning

confidence: 68%

Photoluminescence quenching of dye molecules near a resonant silicon nanoparticle

Zyuzin

Baranov

Escudero

et al. 2018

Sci Rep

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Luminescent molecules attached to resonant colloidal particles are an important tool to study light-matter interaction. A traditional approach to enhance the photoluminescence intensity of the luminescent molecules in such conjugates is to incorporate spacer-coated plasmonic nanoantennas, where the spacer prevents intense non-radiative decay of the luminescent molecules. Here, we explore the capabilities of an alternative platform for photoluminescence enhancement, which is based on low-loss Mie-resonant colloidal silicon particles. We demonstrate that resonant silicon particles of spherical shape are more efficient for photoluminescence enhancement than their plasmonic counterparts in spacer-free configuration. Our theoretical calculations show that significant enhancement originates from larger quantum yields supported by silicon particles and their resonant features. Our results prove the potential of high-index dielectric particles for spacer-free enhancement of photoluminescence, which potentially could be a future platform for bioimaging and nanolasers.

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Section: Resultsmentioning

confidence: 68%

Photoluminescence quenching of dye molecules near a resonant silicon nanoparticle

Zyuzin

Baranov

Escudero

et al. 2018

Sci Rep

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“…Exciting discoveries related to nanoparticle‐cell interactions rely on the use of fluorescent compounds for bioimaging . Such imaging may provide fundamental insight on the basic parameters that dictate nanoparticle performance and thus constitutes an essential step in the characterization of nanomedicines.…”

Section: Introductionmentioning

confidence: 99%

“…To address this need, luminescent rare earth‐based inorganic nanoparticles (nanophosphors) have been explored as bioimaging agents due to their high photostability, sharp emission bands and relatively low toxicity . However, a major obstacle on the broad employment of nanophosphors in bioimaging is their short‐wavelength UV excitation that results in either suboptimal luminescence with conventional microscopes or necessity to use expensive equipment (e.g., laser confocal scanning microscopes).…”

Section: Introductionmentioning

confidence: 99%

“…Flame nanoparticle synthesis provides a scalable and highly reproducible process for production of nanophosphors (e.g., Y 2 O 3 :Eu 3+ /Tb 3+ ) with precise control of their properties . This allowed to identify the optimal Bi‐content for maximum red‐shift of the excitation band edge of flame‐made YVO 4 :Eu 3+ /Bi nanophosphors, for the first time here, through precise control of their composition. The nanophosphors with the optimal Bi‐content were then incubated with HeLa cells and the mean luminescence intensity per cell was determined by fluorescence microscopy image analysis, providing a measure of the cell‐associated nanoparticle dose with time.…”

Section: Introductionmentioning

confidence: 99%

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Near‐UV activated, photostable nanophosphors for in vitro dosimetry and dynamic bioimaging

et al. 2018

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Luminescent rare earth nanoparticles exhibit superior optical stability over commonly-used organic dyes and higher biocompatibility over quantum dots, rendering them advantageous as bioimaging nanoprobes. However, their typical excitation inhibits their broad employment with conventional fluorescence microscopes and, thus, solutions are sought to shift their activation in the long-wavelength (near-UV) spectral region. Here, we synthesize YVO 4 :Eu 31 nanophosphors by flame aerosol technology to systematically study the effect of Bi 31 codoping on their luminescence. That way, we identify an optimal Bi-content for sufficient near-UV activation. These nanophosphors are highly crystalline and appeared bright red under a conventional fluorescence microscope, facilitating bioimaging with HeLa cells and in vitro dosimetry correlations in the presence and absence of serum. The nanophosphor superiority over organic-dye-labeled silica nanoparticles is shown during dynamic imaging for 4 h without photobleaching for the former. These YVO 4 :Eu 31 /Bi 31 nanophosphors can provide a non-photobleaching tool for further dynamic nanoparticle-cell interaction studies with conventional fluorescence microscopes.

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“…Frequently used additives for the functionalization of RE-based NPs are sodium citrate, PAA, PEG and derivate, poly(allylamine hydrochloride) (PAH), poly(sodium 4-styrenesulfonate) (PSS), 1,2-distearoyl-snglycero-3-phospho-ethanolamine-N-[methoxy(poly-ethyleneglycol)-2000] (ammonium salt) and the amphiphilic polymer poly(isobutylene-alt-maleic anhydride) modified with dodecylamine (PMA) and its derivate [74,141]. A functionalization step is mandatory for hydrophobic NPs synthesized in organic media [83].…”

Section: Functionalization Strategiesmentioning

confidence: 99%

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

et al. 2017

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Abstract:Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose of this review is to provide a general and comprehensive overview of the current state of the art, with special focus on the commonly employed synthesis methods and functionalization strategies of rare earth based nanoparticles and on their different bioimaging and biosensing applications. The luminescent (including downconversion, upconversion and permanent luminescence) and magnetic properties of rare earth based nanoparticles, as well as their ability to absorb X-rays, will also be explained and connected with their luminescent, magnetic resonance and X-ray computed tomography bioimaging applications, respectively. This review is not only restricted to nanoparticles, and recent advances reported for in other nanostructures containing rare earths, such as metal organic frameworks and lanthanide complexes conjugated with biological structures, will also be commented on.

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Luminescent Rare-earth-based Nanoparticles: A Summarized Overview of their Synthesis, Functionalization, and Applications

Cited by 6 publications

References 77 publications

Photoluminescence quenching of dye molecules near a resonant silicon nanoparticle

Photoluminescence quenching of dye molecules near a resonant silicon nanoparticle

Near‐UV activated, photostable nanophosphors for in vitro dosimetry and dynamic bioimaging

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

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