Luminescent Mesoporous Silica Nanohybrid Based on Drug Derivative Terbium Complex

Maturi, Fernando E.; Sábio, Rafael Miguel; Silva, Robson R.; Lahoud, Marcelo G.; Meneguin, Andréía Bagliotti; Valente, Gustavo T.; Caface, Raphael Antonio; Leite, Ilaiáli Souza; Inada, Natália Mayumi; Ribeiro, Sidney José Lima

doi:10.3390/ma12060933

Cited by 12 publications

(12 citation statements)

References 48 publications

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“…LYC solutions with MSNs were kept under stirring (100 RPM) for different times (6; 12; 24; 36; 48 h) under cooling (15 o C ± 5). After, LYC-loaded MSNs are centrifuged at 4000 rpm for 15 min and dried at room temperature under vacuum (Maturi et al, 2019;Sábio et al, 2019). The supernatant from the centrifugation was collected, ltered and analyzed by HPLC using the method under validation in order to determine the encapsulated e cacy percentage (EE%) and loading degree percentage (LD%), according to Equations 1 and 2 (Carolina Alves et al, 2019):…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the TGA, in the incorporation condition considered as ideal, the DSC curve was performed (Figure 12), as well for the MSN-R and the free drug. It is possible to observe that the three DSC curves have a rst endothermic event (up to 150 °C), attributed to loss of water or solvents adsorbed in the samples (Maturi et al, 2019). According to the literature, lycopene may have two possible melting points, the rst in the region of 169.48 °C, referring to the cis isomer, and the second around 176.35 °C, referring to the trans isomer.…”

Section: Differential Scattering Calorimetry (Dsc)mentioning

confidence: 97%

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Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation

Carvalho

Nascimento

Camargo

et al. 2023

Preprint

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Lycopene (LYC), a carotenoid extracted mainly from tomatoes, has several biological properties, making its use desirable as a nutraceutical and pharmaceutical active ingredient. However, the use of LYC in therapy has limitations related to its solubility and stability. In this study, mesoporous silica nanoparticles (MSNs) are used to load and protect LYC from degradation. The exact amount of drug incorporated was determined by analytical techniques, such as high performance liquid chromatography (HPLC) and thermal analysis. For this we developed and validated an HPLC method for LYC quantification and evaluated the LYC impregnated in MSNs, followed by thermogravimetry analysis (TGA) technique analysis. Differential scanning calorimetry (DSC) was also used in order to confirm drug incorporation. Additionally, an in vitrorelease study was also carried out. The HPLC method was duly validated for the range of 26–125 µg/mL and proved to be suitable for LYC quantification. DSC measurements suggest an improvement in the stability of the impregnated drug, which was reinforced by the release assay. Overall, the developed method is suitable to test LYC-loaded porous materials to enable the use in therapeutic applications.

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Section: Methodsmentioning

confidence: 99%

Section: Differential Scattering Calorimetry (Dsc)mentioning

confidence: 97%

Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation

Carvalho

Nascimento

Camargo

et al. 2023

Preprint

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“…The synthesis was performed according to NANDIYANTO et al [ 69 ] and MATURI et al [ 70 ] with adaptations. In a round bottom flask, 0.61 g of CTAB and 180 mL of distilled water were added and kept under stirring at 60 °C for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Lycopene, Mesoporous Silica Nanoparticles and Their Association: A Possible Alternative against Vulvovaginal Candidiasis?

et al. 2022

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Commonly found colonizing the human microbiota, Candida albicans is a microorganism known for its ability to cause infections, mainly in the vulvovaginal region known as vulvovaginal candidiasis (VVC). This pathology is, in fact, one of the main C. albicans clinical manifestations, changing from a colonizer to a pathogen. The increase in VVC cases and limited antifungal therapy make C. albicans an increasingly frequent risk in women’s lives, especially in immunocompromised patients, pregnant women and the elderly. Therefore, it is necessary to develop new therapeutic options, especially those involving natural products associated with nanotechnology, such as lycopene and mesoporous silica nanoparticles. From this perspective, this study sought to assess whether lycopene, mesoporous silica nanoparticles and their combination would be an attractive product for the treatment of this serious disease through microbiological in vitro tests and acute toxicity tests in an alternative in vivo model of Galleria mellonella. Although they did not show desirable antifungal activity for VVC therapy, the present study strongly encourages the use of mesoporous silica nanoparticles impregnated with lycopene for the treatment of other human pathologies, since the products evaluated here did not show toxicity in the in vivo test performed, being therefore, a topic to be further explored.

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“…The light beam direction mechanism is managed by computerized systems. The images obtained, by synchronizing the detection device with the excitation beam, are particularly defined and spectacular, and can allow the different molecules present in the preparation to be highlighted in different colors, making it possible to appreciate their three-dimensionality [53,54] (Figure 4, Figure 5, Figure 6 and Figure 7).…”

Section: Methodsmentioning

confidence: 99%

Sandblasted and Acid Etched Titanium Dental Implant Surfaces Systematic Review and Confocal Microscopy Evaluation

et al. 2019

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The field of dental implantology has made progress in recent years, allowing safer and predictable oral rehabilitations. Surely the rehabilitation times have also been reduced, thanks to the advent of the new implant surfaces, which favour the osseointegration phases and allow the clinician to rehabilitate their patients earlier. To carry out this study, a search was conducted in the Pubmed, Embase and Elsevier databases; the articles initially obtained according to the keywords used numbered 283, and then subsequently reduced to 10 once the inclusion and exclusion criteria were applied. The review that has been carried out on this type of surface allows us to fully understand the features and above all to evaluate all the advantages or not related. The study materials also are supported by a manufacturing company, which provided all the indications regarding surface treatment and confocal microscopy scans. In conclusion, we can say that, thanks to these new surfaces, it has been possible to shorten the time necessary to obtain osseointegration and, therefore, secondary stability on the part of implants. The surfaces, therefore, guarantee an improved cellular adhesion and thanks to the excellent wettability all the biological processes that derive from it, such as increases in the exposed implant surface, resulting in an increase in bone-implant contact (BIC).

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Luminescent Mesoporous Silica Nanohybrid Based on Drug Derivative Terbium Complex

Cited by 12 publications

References 48 publications

Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation

Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation

Lycopene, Mesoporous Silica Nanoparticles and Their Association: A Possible Alternative against Vulvovaginal Candidiasis?

Sandblasted and Acid Etched Titanium Dental Implant Surfaces Systematic Review and Confocal Microscopy Evaluation

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