Luminescent Ir(III) Complex Exclusively Made of Polypyridine Ligands Capable of Intercalating into Calf-Thymus DNA

Campagna, Sebastiano; Cavazzini, Marco; Cusumano, Matteo; Pietro, Maria Letizia Di; Giannetto, Antonino; Puntoriero, Fausto; Quici, Silvio

doi:10.1021/ic2010437

Cited by 12 publications

(8 citation statements)

References 44 publications

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“…In a different paper, [Ir(trpy)(trpy-biphen)] 3+ has been shown to bind to CT DNA by intercalation (in contrast to the parent compound [Ir(trpy) 2 ] 3+ which does not intercalate). 40 Interaction of this complex with [poly(dA-dT) 2 ] leads to an enhancement of the luminescence intensity and lifetime; in contrast, incubation of the complex with [poly(dG-dC) 2 ] leads to quenching of the emission which is consistent with the wellestablished fact that guanine is an efficient quencher (via electron transfer processes) of emission. Further photophysical studies with CT DNA were presented and the results could be rationalised from the data using the results described above with the artificial oligonucleotides.…”

Section: Metallo-intercalatorssupporting

confidence: 72%

Interaction of metal complexes with nucleic acids

Łęczkowska

Vilar

2012

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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This chapter reviews the literature reported during 2011 in the field of interaction of metal complexes with nucleic acids, also covering complex formation between transition metal ions and coordinating moieties within nucleic acids. As for the previous year, we have divided the chapter into three sections. The first focuses on the interaction of metal centres with DNA and is organised according to mode of interaction. The second section presents studies of metal complexes and metal ions that interact with RNA. In the last section we discuss examples where transition metals occupy coordination sites covalently incorporated within nucleic acids strands. HighlightsThe photocontrolled DNA binding of an organometallic Ru II complex conjugated to a peptide has been reported. 1 The first X-ray crystal structure of a ruthenium polypyridyl complex bound to a nucleic acid has been solved. 2 Time-resolved IR (TRIR) spectroscopy has been used for the first time to observe DNA-mediated CT between photooxidants and guanine in well-defined covalent constructs. 3 A cyclometallated platinum(II) complex has been shown to selectively block the association of CREB transcription factor and DNA. 4 A report showing the enzymatic incorporation of a salen metal complex into the DNA, which can be replicated and amplified by PCR, has been published. 5 The first metallo-DNA bridged device for direct measurement of conductance via single-molecular break junctions has been reported.

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Section: Metallo-intercalatorssupporting

confidence: 72%

Interaction of metal complexes with nucleic acids

Łęczkowska

Vilar

2012

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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“…6 Recently, it has been shown that a luminescent bis-terdentate iridium(III) complex made exclusively of terpyridine-type-like ligands (C/N = 0/6) exhibits intercalation between DNA base pairs. 7 The luminescence of this complex is quenched in the presence of a guanine moiety via a photoinduced electron-transfer process, showing the high oxidizing ability of the excited state. Although displaying spectroelectrochemical properties enabling photoreactions toward DNA, iridium(III) complexes have only been scarcely used as such in the literature.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Upon replacement of the imidazolo ligand by an intercalative ligand dppz (dppz = dipyrido[3,2- a :2′,3′- c ]phenazine), the resulting luminescent iridium(III) has been used to study DNA-mediated hole and electron transfer . Recently, it has been shown that a luminescent bis-terdentate iridium(III) complex made exclusively of terpyridine-type-like ligands (C/N = 0/6) exhibits intercalation between DNA base pairs . The luminescence of this complex is quenched in the presence of a guanine moiety via a photoinduced electron-transfer process, showing the high oxidizing ability of the excited state.…”

Section: Introductionmentioning

confidence: 99%

Selective DNA Purine Base Photooxidation by Bis-terdentate Iridium(III) Polypyridyl and Cyclometalated Complexes

2014

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Two bis-terdentate iridium(III) complexes with polypyridyl and cyclometalated ligands have been prepared and characterized. Their spectroscopic and electrochemical properties have been studied, and a photophysical scheme addressing their properties is proposed. Different types of excited states have been considered to account for the deactivation processes in each complex. Interestingly, in the presence of mono- or polynucleotides, a photoinduced electron-transfer process from a DNA purine base (i.e., guanine or adenine) to the excited complex is shown through luminescence quenching experiments. For the first time, this work reports evidence for selective DNA purine bases oxidation by excited iridium(III) bis-terdentate complexes.

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“…It was shown that photoinduced electron transfer and charge recombination (back electron transfer) becomes more efficient across the DNA base stack. The efficiency and yield of these processes are also a function of the base sequence into which the metal-binding agent fits, due to the different redox potentials of the transition metal complexes and the different bases [130][131][132].…”

Section: Effects Of Tuning the Photophyisical And Redox Propertiesmentioning

confidence: 99%

Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

et al. 2021

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Transition metal complexes with dppz-type ligands (dppz = dipyrido[3,2-a:2′,3′-c]phenazine) are extensively studied and attract a considerable amount of attention, becoming, from the very beginning and increasingly over time, a powerful tool for investigating the structure of the DNA helix. In particular, [Ru(bpy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ and their derivatives were extensively investigated as DNA light-switches. The purpose of this mini-review, which is not and could not be exhaustive, was to first introduce DNA and its importance at a biological level and research in the field of small molecules that are capable of interacting with it, in all its forms. A brief overview is given of the results obtained on the Ru-dppz complexes that bind to DNA. The mechanism of the light-switch active in this type of species is also briefly introduced along with its effects on structural modifications on both the dppz ligand and the ancillary ligands. Finally, a brief mention is made of biological applications and the developments obtained due to new spectroscopic techniques, both for understanding the mechanism of action and for cellular imaging applications.

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Luminescent Ir(III) Complex Exclusively Made of Polypyridine Ligands Capable of Intercalating into Calf-Thymus DNA

Cited by 12 publications

References 44 publications

Interaction of metal complexes with nucleic acids

Interaction of metal complexes with nucleic acids

Selective DNA Purine Base Photooxidation by Bis-terdentate Iridium(III) Polypyridyl and Cyclometalated Complexes

Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

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