Luminescent imaging of insulin amyloid aggregation using a sensitive ruthenium-based probe in the red region

Detection and disaggregation of amyloid fibrils by luminescent amphiphilic platinum(ii) complexes

“…1). 36–40 Carlos, et al have examined related Ru(phen) 2 (aminopyridine) 2 2+ complexes for monitoring Aβ and insulin amyloid aggregation, 41–43 while Zhong, et al have reported a tris(heteroleptic) Ru(dipyridophenazine) 2+ complex that exhibits dual emission for ratiometric monitoring of amyloid aggregation. 44 Several rhenium( i ) complexes have been used for luminescence detection of Aβ fibrils.…”

Ruthenium complexes bearing glucosyl ligands are able to inhibit the amyloid aggregation of short histidine-peptides

“…21 It was also employed as a probe for the detection of fibrillar insulin. 22,23 Similarly, the complex {[Ru(bpy) 2 (dpqp)] 2+ } has a luminescence anisotropy that allows for the tracking of the formation of amyloid oligomers at different time points for Aβ and α-synuclein, 24 leading to in-cell mechanistic insights in the early stages of amyloid formation. 25…”