Luminescent chemosensor for Hg2+ ion based on a dinuclear Ru(II) complex containing open chain azacrown ether

Cheng, Feixiang; Ren, Mingli; He, Chang; Yin, Hengfu

doi:10.1016/j.ica.2016.05.040

“…N , N’ ‐((5‐azido‐1,3‐phenylene)bis(methylene))bis(1,10‐phenanthrolin‐5‐amine) ( E ): The ligand E was synthesised using a similar procedure reported in literature with some modifications [37] . Compound 11 (100 mg, 0.19 mmol) was treated with NaBH 4 (21 mg, 0.56 mmol) in 10 mL of dry MeOH at room temperature overnight.…”

Section: Methodsmentioning

confidence: 99%

“…2924, 2853, 2131, 1689, 1595, 1463, 1392, 1379, 1316. (1E,1'E)-1,1'-(5-azido-1,3-phenylene)bis(N-(1,10-phenanthrolin-5-yl)methanimine) (11): The compound 11 was synthesised using asimilar procedure reported in literature with some modifications. [37] Compound 10 (100 mg, 0.57 mmol) and 8 (330 mg, 1.71 mmol) were stirred in 10 mL dry MeOH under reflux and overnight with catalytic amount of glacial acetic acid. Afterwards, ah ot filtration was performed.…”

Section: Methodsmentioning

confidence: 99%

“…FT-IR (ATR, cm À1 ): 3332, 3030, 2109, 1631, 1581, 1420, 1312, 1136, 1060bis(methylene))bis(1,10-phenanthrolin-5-amine) (E): The ligand E was synthesised using as imilar procedure reported in literature with some modifications. [37] Com-pound 11 (100 mg, 0.19 mmol) was treated with NaBH 4 (21 mg, 0.56 mmol) in 10 mL of dry MeOH at room temperature overnight. The mixture was dried under vacuum and purified with silica gel column chromatography in DCM:MeOH with gradient 9:1-8:2 and 1% ammonia.…”

Section: Methodsmentioning

confidence: 99%

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A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors

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Chemistry A European J

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Nucleic acid click chemistry was used to prepare a family of chemically modified triplex forming oligonucleotides (TFOs) for application as a new gene‐targeted technology. Azide‐bearing phenanthrene ligands—designed to promote triplex stability and copper binding—were ‘clicked’ to alkyne‐modified parallel TFOs. Using this approach, a library of TFO hybrids was prepared and shown to effectively target purine‐rich genetic elements in vitro. Several of the hybrids provide significant stabilisation toward melting in parallel triplexes (>20 °C) and DNA damage can be triggered upon copper binding in the presence of added reductant. Therefore, the TFO and ‘clicked’ ligands work synergistically to provide sequence‐selectivity to the copper cutting unit which, in turn, confers high stabilisation to the DNA triplex. To extend the boundaries of this hybrid system further, a click chemistry‐based di‐copper binding ligand was developed to accommodate designer ancillary ligands such as DPQ and DPPZ. When this ligand was inserted into a TFO, a dramatic improvement in targeted oxidative cleavage is afforded.

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“…To detect these metal ions in biological and environmental systems, a number of Ru(II) complex chemosensors have been developed in the past few decades. In this section, the progress in the development of chemosensors for Cu 2+ , Hg 2+ [ 120 ] and others will be discussed according to the types of ions.…”

Section: Ru(ii) Complex Chemosensors For Metal Ionsmentioning

confidence: 99%

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

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Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and thus many Ru(II) complexes have been designed and synthesized for the detection of ions and small biomolecules in biological and environmental samples. In this work, we summarize the research advances in the development of Ru(II) complex-based chemosensors for the determination of ions and small biomolecules, including anions, metal ions, reactive biomolecules and amino acids, with a particular focus on binding/reaction-based chemosensors for the investigation of intracellular analytes’ evolution through luminescence analysis and imaging. The advances, challenges and future research directions in the development of Ru(II) complex-based chemosensors are also discussed.

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“…In [118]. Copyright 2020 American Chemical Society this section, the progress in the development of chemosensors for Cu 2+ , Hg 2+ [120] and others will be discussed according to the types of ions.…”

Section: Ru(ii) Complex Chemosensors For Metal Ionsmentioning

confidence: 99%

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

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Metal Ligand Chromophores for Bioassays

View full text Add to dashboard Cite

Luminescence chemosensors are one of the most useful tools for the determination and imaging of small biomolecules and ions in situ in real time. Based on the unique photo-physical/-chemical properties of ruthenium(II) (Ru(II)) complexes, the development of Ru(II) complex-based chemosensors has attracted increasing attention in recent years, and thus many Ru(II) complexes have been designed and synthesized for the detection of ions and small biomolecules in biological and environmental samples. In this work, we summarize the research advances in the development of Ru(II) complex-based chemosensors for the determination of ions and small biomolecules, including anions, metal ions, reactive biomolecules and amino acids, with a particular focus on binding/reaction-based chemosensors for the investigation of intracellular analytes’ evolution through luminescence analysis and imaging. The advances, challenges and future research directions in the development of Ru(II) complex-based chemosensors are also discussed.

show abstract

Luminescent chemosensor for Hg2+ ion based on a dinuclear Ru(II) complex containing open chain azacrown ether

Cited by 5 publications

References 64 publications

A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors

A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

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