Luminescence sensitization of Tb 3+ -DNA complexes by Ag +

Xu, Lijun; Zhou, Lu; Chen, Xing; Wang, Jine; Zhang, Jianye; Pei, Renjun

doi:10.1016/j.saa.2017.03.001

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…For example, most alkali-metal ions are grouped more closely except for K (Figures a,b and S11), which can be interpreted as K-binding G-rich DNA would form a specific structure, resulting in unique pattern responses for understanding the K–DNA interactions. Likewise, the coordination of Ag to GT bases increases the rigidities of DNA ligands, , thus enhancing the luminescence of Tb (Figure a–d), and Ag possesses more dissimilarity compared to other transition/post-transition metal ions (Figure e). Notably, this simple pattern recognition system can discriminate between highly similar lanthanide ions while allowing their analysis and grouping even with just three DNA/Tb sensors (Figure f), and we can clearly see that Tb locates more uniquely in the PCA plot than other grouped lanthanide ions due to its distinct interaction with DNA .…”

Section: Resultsmentioning

confidence: 99%

“…For example, most alkali-metal ions are grouped more closely except for K (Figures3a,b and S11), which can be interpreted as K-binding G-rich DNA would form a specific structure,31 resulting in unique pattern responses for understanding the K− DNA interactions. Likewise, the coordination of Ag to GT bases increases the rigidities of DNA ligands,22,32 thus enhancing the luminescence of Tb (Figure1a−d), and Ag possesses more dissimilarity compared to other transition/posttransition metal ions (Figure…”

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confidence: 99%

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DNA Encountering Terbium(III): A Smart “Chemical Nose/Tongue” for Large-Scale Time-Gated Luminescent and Lifetime-Based Sensing

et al. 2018

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Recent years have witnessed the rapid development of pattern-based sensors due to their potential to detect and differentiate a wealth of analytes with only few probes. However, no one has found or used the combination of DNA and terbium(III) (Tb) as a pattern recognition system for large-scale mix-and-measure assays. Here we report for the first time that DNA-sensitized Tb (DNA/Tb), as a label-free and versatile "chemical nose/tongue", can be employed for wide-scale time-gated luminescent (TGL) monitoring of metal ions covering nearly the entire periodic table in a cost-effective fashion. A series of guanine/thymine (G/T)-rich DNA ligands was screened to sensitize the luminescence of Tb (referring to the antenna effect) as smart pattern responders to metal ions in solution, and metal ion-DNA interactions can differentially alter the antenna effect of DNA toward Tb as pattern signals. Our results show that as few as 3 DNA/Tb label-free sensors could successfully discriminate 49 analytes, including alkali-metal ions, alkaline-earth-metal ions, transition/post-transition metal ions, and lanthanide ions. A blind test with 49 metals further confirmed the discriminating power of DNA/Tb sensors. Moreover, the lifetime-based pattern recognition application using DNA/Tb sensors was also demonstrated. This DNA/Tb pattern recognition strategy could be extended to construct a series of "chemical noses/tongues" for monitoring various biochemical species by using different responsive DNA ligands, thus promising a versatile and powerful tool for a sensing application and investigation of DNA-involving molecular interactions.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

DNA Encountering Terbium(III): A Smart “Chemical Nose/Tongue” for Large-Scale Time-Gated Luminescent and Lifetime-Based Sensing

et al. 2018

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“…Based on the experimental and some literature data [81,82], the following formulas were attributed to the complexes: activity [56][57][58][59][60]. The ability to bind to DNA [61,62] and their luminescent properties [63][64][65] render Ln 3+ and their complexes as potential candidates for nucleic acid imaging [66]. Lanthanides present a high affinity for ligands with donor atoms in the order O > N > S and coordination numbers that vary from 6 to 12 [67].…”

Section: Syntheses Of the Complexesmentioning

confidence: 99%

“…Lanthanide (Ln 3+ ) complexes with different drugs are appealing due to several properties [ 51 ]: the ability to bind to serum albumin [ 52 ], the development of stable MRI contrast agents [ 53 , 54 , 55 ] and the ability to replace cations such as Ca 2+ , Mg 2+ or Zn 2+ as co-factors in metaloenzymes with hydrolytic activity [ 56 , 57 , 58 , 59 , 60 ]. The ability to bind to DNA [ 61 , 62 ] and their luminescent properties [ 63 , 64 , 65 ] render Ln 3+ and their complexes as potential candidates for nucleic acid imaging [ 66 ]. Lanthanides present a high affinity for ligands with donor atoms in the order O > N > S and coordination numbers that vary from 6 to 12 [ 67 ].…”

Section: Introductionmentioning

confidence: 99%

Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies

Măciucă

Arbănași

Mihăilă³

et al. 2020

Molecules

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“Drug repositioning” is a current trend which proved useful in the search for new applications for existing, failed, no longer in use or abandoned drugs, particularly when addressing issues such as bacterial or cancer cells resistance to current therapeutic approaches. In this context, six new complexes of the first-generation quinolone oxolinic acid with rare-earth metal cations (Y3+, La3+, Sm3+, Eu3+, Gd3+, Tb3+) have been synthesized and characterized. The experimental data suggest that the quinolone acts as a bidentate ligand, binding to the metal ion via the keto and carboxylate oxygen atoms; these findings are supported by DFT (density functional theory) calculations for the Sm3+ complex. The cytotoxic activity of the complexes, as well as the ligand, has been studied on MDA-MB 231 (human breast adenocarcinoma), LoVo (human colon adenocarcinoma) and HUVEC (normal human umbilical vein endothelial cells) cell lines. UV-Vis spectroscopy and competitive binding studies show that the complexes display binding affinities (Kb) towards double stranded DNA in the range of 9.33 × 104 − 10.72 × 105. Major and minor groove-binding most likely play a significant role in the interactions of the complexes with DNA. Moreover, the complexes bind human serum albumin more avidly than apo-transferrin.

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Enhanced DNA sensitized Tb3+ luminescence in organic solvents for more sensitive detection

Zhou

Liu

2017

Analytica Chimica Acta

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Luminescence sensitization of Tb 3+ -DNA complexes by Ag +

Cited by 9 publications

References 43 publications

DNA Encountering Terbium(III): A Smart “Chemical Nose/Tongue” for Large-Scale Time-Gated Luminescent and Lifetime-Based Sensing

DNA Encountering Terbium(III): A Smart “Chemical Nose/Tongue” for Large-Scale Time-Gated Luminescent and Lifetime-Based Sensing

Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies

Enhanced DNA sensitized Tb3+ luminescence in organic solvents for more sensitive detection

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