Luminescence properties of Cu and Cu,Al doped ZnS quantum dots

Zhang, Xiaosong; Li, Lan; Kai, Guiyun; Dong, Dongqing; Zhang, Yanfang; Li, Jiangyong

doi:10.1117/12.745742

Cited by 1 publication

(2 citation statements)

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“…In contrast to those results, Cucurbitacin E has been reported by Sorensen and co-workers to inhibit depolymerization of actin filaments by specifically binding to F-actin (but not to monomeric G-actin) forming a covalent bond at residue Cys257 [386]. Interestingly, in in vivo experiments the intraperitoneal administrations of cucurbitacin E significantly reduced breast tumour metastasis to the lung with no effects on apoptosis or proliferation of inoculated breast cancer cells [387]. In vitro cucurbitacin E strongly inhibited migration and invasion of metastatic breast cancer cells.…”

Section: And N-wasp and Arp2/3 Complex And Formin Inhibitorscontrasting

confidence: 62%

“…In vitro cucurbitacin E strongly inhibited migration and invasion of metastatic breast cancer cells. The abrogation of Arp2/3-dependent actin polymerization and the inhibition of the Src/FAK/Rac1/MMP cascade have been identified as the molecular events triggered by cucurbitacin E and underlying the reduction in the cell migratory and invasive abilities [387]. Those data point on cucurbitacin E as a potential candidate for treating breast cancer metastasis.…”

Section: And N-wasp and Arp2/3 Complex And Formin Inhibitorsmentioning

confidence: 93%

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Targeting the cytoskeleton against metastatic dissemination

Ruggiero

Lalli

2021

Cancer Metastasis Rev

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Cancer is a pathology characterized by a loss or a perturbation of a number of typical features of normal cell behaviour. Indeed, the acquisition of an inappropriate migratory and invasive phenotype has been reported to be one of the hallmarks of cancer. The cytoskeleton is a complex dynamic network of highly ordered interlinking filaments playing a key role in the control of fundamental cellular processes, like cell shape maintenance, motility, division and intracellular transport. Moreover, deregulation of this complex machinery contributes to cancer progression and malignancy, enabling cells to acquire an invasive and metastatic phenotype. Metastasis accounts for 90% of death from patients affected by solid tumours, while an efficient prevention and suppression of metastatic disease still remains elusive. This results in the lack of effective therapeutic options currently available for patients with advanced disease. In this context, the cytoskeleton with its regulatory and structural proteins emerges as a novel and highly effective target to be exploited for a substantial therapeutic effort toward the development of specific anti-metastatic drugs. Here we provide an overview of the role of cytoskeleton components and interacting proteins in cancer metastasis with a special focus on small molecule compounds interfering with the actin cytoskeleton organization and function. The emerging involvement of microtubules and intermediate filaments in cancer metastasis is also reviewed.

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Section: And N-wasp and Arp2/3 Complex And Formin Inhibitorscontrasting

confidence: 62%

Section: And N-wasp and Arp2/3 Complex And Formin Inhibitorsmentioning

confidence: 93%