Luminescence of Tiopronin Monolayer-Protected Silver Clusters Changes To That of Gold Clusters upon Galvanic Core Metal Exchange

Huang, Tao; Murray, Royce W.

doi:10.1021/jp0276956

Cited by 92 publications

(102 citation statements)

References 35 publications

(56 reference statements)

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“…44 Initially used to stabilize gold nanoparticles, the synthesis has been adapted to produce silver nanoparticles with the same stability and solubility. 45 This stability results from the strong interactions (particularly hydrogen bonds) between the ligands in the capping layer and allows the nanoparticles to be isolated and re-dispersed without agglomeration. It is this re-dispersion from a solid that makes the silver-tiopronin particles suitable for incorporation into bone cement.…”

Section: Discussionmentioning

confidence: 99%

A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

Prokopovich¹,

Leech²,

Carmalt³

et al. 2013

IJN

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Post-operatory infections in orthopedic surgeries pose a significant risk. The common approach of using antibiotics, both parenterally or embedded in bone cement (when this is employed during surgery) faces the challenge of the rising population of pathogens exhibiting resistance properties against one or more of these compounds; therefore, novel approaches need to be developed. Silver nanoparticles appear to be an exciting prospect because of their antimicrobial activity and safety at the levels used in medical applications. In this paper, a novel type of silver nanoparticles capped with tiopronin is presented. Two ratios of reagents during synthesis were tested and the effect on the nanoparticles investigated through TEM, TGA, and UV-Vis spectroscopy. Once encapsulated in bone cement, only the nanoparticles with the highest amount of inorganic fraction conferred antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA) at concentrations as low as 0.1% w/w. No other characteristics of the bone cement, such as cytotoxicity or mechanical properties, were affected by the presence of the nanoparticles. Our work presents a new type of silver nanoparticles and demonstrates that they can be embedded in bone cement to prevent infections once the synthetic conditions are tailored for such applications.

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Section: Discussionmentioning

confidence: 99%

A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

Prokopovich¹,

Leech²,

Carmalt³

et al. 2013

IJN

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“…[6] This potentiality is exploited more in the case of Au nanoparticles than it is for Ag nanoparticles despite the known fact that Ag nanoparticles exhibit higher efficiency of plasmon excitation. [2] However, the propensity of pure Ag nanoparticles to undergo oxidative corrosion [7] and aggregation in electrolytic solutions [8] limit their usage, especially for biological applications. The oxidative corrosion and aggregation of Ag nanoparticles can be attenuated or eliminated with a protective layer, such as organic cap ligands or inorganic coatings, which allow stable nanoparticle solutions to exist even at high NaCl concentrations and over a wide range of pH values.…”

Section: Introductionmentioning

confidence: 99%

Size‐Controlled Water‐Soluble Ag Nanoparticles

et al. 2007

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Ag nanoparticles of two different sizes (1 and 4 nm) were prepared within an apoferritin cavity by using an Ag+‐loaded apoferritin as a nanoconfined environment for their construction. The initial amount of Ag+ ions injected in the apoferritin cavity dictates the size of the final Ag particles. The protein shell prevents bulk aggregation of the metal particles, which renders them water soluble and extremely stable.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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“…1b); this feature is consistent with that observed by Huang et al for similarly prepared and sized Ag NPs. 16 On the other hand, the NCs exhibited sharp ligand-to-metal-metal charge transfer (LMMCT) peaks at 275 nm and 374 nm (see Fig. 1b) arising from the Ag thiolate chains, 1,13,14,23-25 but no SPRrelated feature (note: the same intense peak at 374 nm also appears in the UV-vis of the Agthiolate complex, 13 and thus is not the SPR peak ).…”

Section: Tem and Uv-vis Characterizationmentioning

confidence: 99%

The structure and bonding properties of tiopronin-protected silver nanoparticles as studied by X-ray absorption spectroscopy

2018

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Thiolate-protected Ag nanoparticles (NPs) exhibit interesting physical and chemical properties which may lead to various sensing, diagnostic, and therapeutic applications. Further, understanding structure-property relationships of Ag NPs is of great interest in order to optimize their application. Herein, we used TEM, UV-vis, and a series of synchrotron X-ray spectroscopy techniques to probe the local structure and chemical bonding properties of thiolate-stabilized Ag NPs. Compared with other Ag nanostructures prepared under slightly modified conditions, the Ag NPs were found to have pronounced structural changes, which led to immensely different optical properties. Notably, the NPs were also found to have similar surface structure to recently elucidated Ag nanoclusters prepared with different thiolates. These findings suggest that the NP structure and optical properties can be sensitively tailored by controlling the synthetic conditions. The multi-element, multi-core excitation approach (i.e., Ag K-, Ag L 3 -, and S K-edges) employed in the X-ray absorption spectroscopy measurements was also demonstrated as an effective tool to uncover the NP structure from both the metal core and ligand shell perspectives.

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Luminescence of Tiopronin Monolayer-Protected Silver Clusters Changes To That of Gold Clusters upon Galvanic Core Metal Exchange

Cited by 92 publications

References 35 publications

A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

Size‐Controlled Water‐Soluble Ag Nanoparticles

The structure and bonding properties of tiopronin-protected silver nanoparticles as studied by X-ray absorption spectroscopy

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Luminescence of Tiopronin Monolayer-Protected Silver Clusters Changes To That of Gold Clusters upon Galvanic Core Metal Exchange

Cited by 92 publications

References 35 publications

A novel bone cement impregnated with silver&ndash;tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

A novel bone cement impregnated with silver&ndash;tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

Size‐Controlled Water‐Soluble Ag Nanoparticles

The structure and bonding properties of tiopronin-protected silver nanoparticles as studied by X-ray absorption spectroscopy

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Product

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A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties