Luminescence from protoporphyrin IX dimethyl ester

Chantrell, S.J.; McAuliffe, Charles A.; Munn, R. W.; Pratt, Albert C.; Land, Edward J.

doi:10.1039/c39750000470

Cited by 3 publications

(2 citation statements)

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“…PpIX is a frequently used photosensitizer and presents a delayed fluorescence, [54][55][56] while PdTCPP is a commonly used oxygen sensor for in vivo measurements. 29,31,32,49,57 Luminescence decays were thus measured at decreasing concentrations ranging between 10 −4 and 10 −7 M, within 1 h of sample preparation.…”

Section: Setup Calibration and System Sensitivitymentioning

confidence: 99%

Optical fiber-based setup for in vivo measurement of the delayed fluorescence lifetime of oxygen sensors

et al. 2011

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A new optical-fiber-based spectrofluorometer for in vivo or in vitro detection of delayed fluorescence is presented and characterized. This compact setup is designed so that it can be readily adapted for future clinical use. Optical excitation is done with a nitrogen laser-pumped, tunable dye laser, emitting in the UV-vis part of the spectrum. Excitation and luminescence signals are carried to and from the biological tissues under investigation, located out of the setup enclosure, by a single optical fiber. These measurements, as well as measurements performed without a fiber on in vitro samples in a thermostable quartz cell, in a controlled-atmosphere enclosure, are possible due to the efficient collection of the laser-induced luminescence light which is collected and focused on the detector with a high aperture parabolic mirror. The detection is based on a gated photomultiplier which allows for time-resolved measurements of the delayed fluorescence intensity. Thus, relevant luminescence lifetimes, typically in the sub-microsecond-to-millisecond range, can be measured with near total rejection of the sample's prompt fluorescence. The instrument spectral and temporal resolution, as well as its sensitivity, is characterized and measurement examples are presented. The primary application foreseen for this setup is the monitoring and adjustment of the light dose delivered during photodynamic therapy.

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Section: Setup Calibration and System Sensitivitymentioning

confidence: 99%

Optical fiber-based setup for in vivo measurement of the delayed fluorescence lifetime of oxygen sensors

et al. 2011

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“…The current theoretical understanding of "normal," "hyper," and "free-base" electronic structure and spectra have resulted from such semiempirical calculations. Chantrell et al [3] have written a review of various porphyrin calculations using these techniques. macrocyle center.…”

Section: Previous Porphyrin Calculationsmentioning

confidence: 99%

Theoretical investigations of the electronic states of porphyrins. II. Normal and hyper phosphorus porphyrins

Rawlings

Davidson

Gouterman

1984

Int J of Quantum Chemistry

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Ah inifio methods have been used to calculate the ground and excited states of "normal" and "hyper" porphyrins. Perturbation theory and C I methods were used to determine differential groundand excited-state correlation effects for [P"(P)F,]+ and [P"'(P)]+. A comparison is made to the INDO/S/CI predicted wavefunctions and spectra and to the experimental spectra of closely related molecules. The "hyper" [P"'(P)]+ calculations show some very low energy electronic transitions which provide an explanation for an anomalous "red" band in the spectrum and for the lack of fluorescence. Ah initio calculations also predict that (1) the lowest energy ' A , state is a two-configuration wavefunction which can be described as a diradical, (2) the two lowest-energy singlet excited states are double excitations from the closed shell SCF configuration, and (3) a 38, state is very close in energy to the lowest ' A , state.

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