Luminescence behavior of colloid quantum dots in the presence anthracycline antibiotic mitoxantrone: Surface interaction and luminescence quenching, size and composition dependence, potential for clinical study

Spectroelectrochemical Analysis of Ion Transfer Mechanisms of Mitoxantrone at Liquid|Liquid Interfaces: Effects of Zwitterionic Dendrimer and Phospholipid Layer

“…Although the broad emission peak appeared around 738 nm in aqueous solutions at both pH 7 and 5.4, the spectral characteristics of interfacial species are not identical to those of aqueous solution species. In bulk solutions, it is known that the low emissive H-type dimer of MTX is formed through the π–π interaction of anthraquinone chromophores at higher concentrations. , According to the potential dependent adsorption models, , the interfacial amount of a surface-active transferring ion is maximized around its transfer potential. The broad shoulder peak around 748 nm could relate to the interfacial formation of emissive J-aggregates induced by a significant increase in the adsorption amount of H 2 MTX 2+ around Δ o w ϕ H 2 MTX 2 + ° ′ .…”

“…Although the broad emission peak appeared around 738 nm in aqueous solutions at both pH 7 and 5.4, the spectral characteristics of interfacial species are not identical to those of aqueous solution species. In bulk solutions, it is known that the low emissive H-type dimer of MTX is formed through the π–π interaction of anthraquinone chromophores at higher concentrations. , According to the potential dependent adsorption models, , the interfacial amount of a surface-active transferring ion is maximized around its transfer potential. The broad shoulder peak around 748 nm could relate to the interfacial formation of emissive J-aggregates induced by a significant increase in the adsorption amount of H 2 MTX 2+ around .…”

“…The PMF experiment was conducted by using the p-polarized excitation beam at 660 nm close to the absorption and excitation maxima of the MTX monomer in aqueous solution. 40,41 The PMF results in Figure 4b demonstrated the adsorption and transfer processes of cationic species (HMTX + ) with ΔF re > 0 and ΔF im < 0 (see SI: S2 for details) at Δ o w ϕ > 0.15 V, where the peak responses were found around 0.26 V. In the higher potential region (Δ o w ϕ > 0.34 V), the reversed PMF signals (ΔF re < 0, ΔF im > 0) were clearly observed at 1.0 × 10 −4 mol dm −3 MTX, indicating that the adsorption process took place also at the organic side of the interface. It is noteworthy that no clear signal at potentials less than 0.15 V was measured in the PMF data obtained with the p-polarized excitation beam.…”