Luminal-Type Breast Cancer: Correlation of Apparent Diffusion Coefficients with the Ki-67 Labeling Index

Abstract

Considering convenience for routine practice, the authors suggest that the mean ADC apparent diffusion coefficient of the conventional method would be practical to use for estimating the Ki-67 labeling index.

Endometrial Stromal Sarcoma of the Uterus: Magnetic Resonance Imaging Findings Including Apparent Diffusion Coefficient Value and Its Correlation With Ki-67 Expression

“…34 Studies have demonstrated that high expression of Ki-67 indicates a high aggressiveness, a high risk of relapse, and a poor prognosis 15,35,36 ; a low ADC value suggests high proliferative activity and consequently a malignant tumor. 37,38 Our study showed similar results. A significant difference in ADC value was found between ESSs with the positive and negative Ki-67 expression.…”

Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer

“…We recently reported that tumours with a high Ki-67 labelling index showed lower ADC values than those with a low Ki-67 labelling index in luminal-type breast cancer NOS [24]. LVI was reported to associate with tumours with a high cell proliferation level or high Ki-67 labelling index [27], which are likely to have lower ADC values.…”

“…2b). We recorded the mean ADC value as the tumour-ADC on the basis of the recent study revealing that the mean value of an as-large-aspossible round or oval ROI inside the tumour correlated with a Ki-67 labelling index in luminal-type breast cancer NOS diagnosed by biopsy [24].…”

DWI in the Assessment of Breast Lesions

“…Within invasive disease, a number of studies have shown ADC values to negatively correlate with tumor grade [17–21]. A similar correlation was seen with tumor proliferation, using Ki-67 index as a marker [13, 21–26]. The ability to detect more aggressive tumors may aid in consideration of neoadjuvant treatment prior to surgery.…”