Lumbar facet joint subchondral bone density in low back pain and asymptomatic subjects

Pan, Chien-Chou; Simon, Péter; Orías, Alejandro A. Espinoza; Takatori, Ryota; An, Howard S.; Andersson, Gunnar; Inoue, Nozomu

doi:10.1007/s00256-019-03314-w

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…37 Finally, previous work has suggested overall facet bone density is higher in patients with back pain versus asymptomatic individuals. 18 Future work should aim to expand characterization of these facet cartilage and bone structurefunction relationships to patient populations with back pain. Nevertheless, our study demonstrates that, similar to the knee and other joints of the body, facet OA is a degenerative disease of both bone and cartilage.…”

Section: Resultsmentioning

confidence: 99%

“…Osteoporosis could be a confounding factor which may account for the loss ofcortical bone, especially with advanced age 37 . Finally, previous work has suggested overall facet bone density is higher in patients with back pain versus asymptomatic individuals 18 . Future work should aim to expand characterization of these facet cartilage and bone structure‐function relationships to patient populations with back pain.…”

Section: Discussionmentioning

confidence: 99%

“…Previous work comparing human osteoarthritic and healthy facets suggests that subchondral cortical plate thickness is reduced while trabecular bone volume fraction is increased 17 . It has also been shown that patients with back pain have higher faet subchondral bone mineral density 18 …”

Section: Introductionmentioning

confidence: 99%

“…17 It has also been shown that patients with back pain have higher faet subchondral bone mineral density. 18 The morphological, biomechanical and histological changes across facet bone and cartilage with degenerationas well as across levels of the human lumbar spine remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration

Gupta

Xiao

Fainor

et al. 2022

Journal Orthopaedic Research

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The zygapophyseal joints of the spine, also known as the facet joints, are paired diarthrodial joints posterior to the intervertebral disc and neural elements. The pathophysiology of facet osteoarthritis (OA), as well as crosstalk between the disc and facets, remains largely understudied compared to disc degeneration. The purpose of this study was to characterize alterations to human facet cartilage and subchondral bone across a spectrum of degeneration and to investigate correlations between disc and facet degeneration. Human lumbar facet articular surfaces from six independent donors were subject to creep indentation mechanical testing to quantify cartilage mechanical properties, followed by microcomputed tomography (µCT) analyses for subchondral bone morphometry.The degenerative state of each articular surface was assessed via macroscopic scoring and via Osteoarthritis Research Society International histopathology scoring. Our data suggest reduced facet cartilage compressive and tensile moduli and increased permeability with increasing degenerative grade, particularly at the lower levels of the spine. µCT analyses revealed spinal level-dependent alterations to the subchondral bone, with an increase in trabecular bone at the L4−L5 level, but a decrease at the upper levels of the lumbar spine with increasing degenerative grade. Cortical bone volume fraction was generally decreased with increasing degenerative grade across spinal levels. Correlation analysis revealed several associations between quantitative measures of disc degeneration and facet OA. This study showed that alterations in the mechanical properties of facet cartilage and in the structural properties of facet subchondral bone correlated with aspects of disc degeneration and were highly dependent on spinal level.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration

Gupta

Xiao

Fainor

et al. 2022

Journal Orthopaedic Research

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“…2 About 55-80% of people suffer from low back pain (LBP) in their lifetime, and the worldwide yearly cost of managing chronic LBP is estimated to be a trillion dollars. 3 The incidence of LBP is linked to several biopsychosocial aspects, including mechanical, traumatic, pathological and degenerative causes; bone health is known to be associated with both degenerative and mechanical types of LBP. 4 Approximately 50% of patients seeking treatment for LBP of over 3 months' duration are found to be additionally suffering from vitamin D and other nutritional deficiencies.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of therapeutic exercise with either an educational booklet or vitamin-D3 supplement in the management of chronic low back pain: study protocol for an assessor blinded multicenter randomized clinical trial

Islam

Hossain

et al. 2022

F1000Res

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Background: It is important to know the best intervention approach to replenish serum vitamin D levels along with therapeutic interventions for chronic low back pain (CLBP) patients. From the researcher’s knowledge, no study compared “vitamin D supplement” or “booklet education on sun exposure, nutrition and lifestyle” with therapeutic exercise for CLBP cases. Researchers hypothesize that multidimensional comprehensive management of therapeutic exercise and an education booklet (TEB) on sun exposure, nutrition, and lifestyle might be superior to therapeutic exercise and oral vitamin D supplement (TED) for CLBP patients with vitamin D deficiency. Methods: We planned for an assessor-blinded two-arm multicenter Randomized Clinical Trial (RCT) protocol to compare the efficacy of TEB compared to TED for CLBP patients with vitamin D deficiency at 2 months and 6 months after baseline recruitment in designated centers in Dhaka city. The primary outcome measures will include pain by Brief Pain Inventory (BPI), and serum vitamin D3 level and secondary outcome measures will include disability by Ronald Morris Disability Questionnaire (RMDQ). Discussion: This study will provide evidence for an appropriate prescription for the management of CLBP patients having vitamin D deficiency. Registration: Clinical Trials Registry India (CTRI/2022/11/047074).

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Imaging of facet joint diseases

Kwee

2021

Clinical Imaging

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Lumbar facet joint subchondral bone density in low back pain and asymptomatic subjects

Cited by 8 publications

References 26 publications

Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration

Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration

Comparison of the effects of therapeutic exercise with either an educational booklet or vitamin-D3 supplement in the management of chronic low back pain: study protocol for an assessor blinded multicenter randomized clinical trial

Imaging of facet joint diseases

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