Lugol chromoendoscopy combined with brush cytology in patients at risk for esophageal squamous cell carcinoma

Abstract

Lugol chromoendoscopy enhances the detection rate of high-risk lesions with dysplasia or carcinoma in situ in large unstained lesions. Biomarkers such as aneuploidy and p53 LOH from brush cytology were not of additional benefit in this setting.

Pharyngo-laryngeal examination with the narrow band imaging technology: early experience

“…Lugol chromoendoscopy enhances the detection rate of high-risk lesions with dysplasia or carcinoma in situ in large unstained lesions. Its application has mainly been limited so far to the esophagus [13]. Indirect fluorescence endoscopy based on autofluorescence or 5-ALA (Amino Lavulenic Acid) induced fluoroscopy has been proved useful for the early diagnosis of laryngeal cancer.…”

Lugol chromoendoscopic screening for esophageal dysplasia/early squamous cell carcinoma in patients with esophageal symptoms in low-risk region in China

“…In the current study, patients were selected with esophageal symptoms and 86 (10.6%) patients were observed to have dysplasia/early carcinoma, among whom 19 (2.3%, 19/812) cases had severe dysplasia/early carcinoma. The detection rate of severe dysplasia/early carcinoma almost reached that of the high-risk population (13)(14)(15)(16)(17). In this study, these patients were divided into three groups according to symptoms, and 8.3% patients who had reflux, 17.2% patients who had dysphagia, and 15.8% patients who had globus sensation, were also observed to have dysplasia/early ESCC.…”

“…It was reported that 27% of moderate/severe dysplasia of the esophagus were not identified in routine endoscopy examinations (6). In previous studies, Lugol chromoendoscopy was predominantly used in high-risk populations or high-risk regions to screen esophageal carcinomas or precancerous lesions (6,(13)(14)(15). The current study screens esophageal dysplasia/early carcinoma in low-risk regions using Lugol chromoendoscopy to evaluate whether Table V.…”

“…In this study, these patients were divided into three groups according to symptoms, and 8.3% patients who had reflux, 17.2% patients who had dysphagia, and 15.8% patients who had globus sensation, were also observed to have dysplasia/early ESCC. The results indicated that increased attention must be given to the patients with esophageal symptoms, and Lugol chromoendoscopy should be recommended as a routine procedure in patients with esophageal symptoms, similarly to those high-risk patients with head and neck, or tracheobronchial squamous cell carcinomas, or had an alcohol or tobacco addiction, or lived in a high-risk region (13)(14)(15)(16)(17).…”

Performance measures for upper gastrointestinal endoscopy: A European Society of Gastrointestinal Endoscopy quality improvement initiative

“…Accurate use of chromoendoscopy in patients with a history of ENT or lung tumors who are treated with curative intent results in a higher diagnostic yield for Eight studies addressed this clinical question specifically in patients with a history of head and neck tumors by comparing conventional white-light endoscopy with Lugol chromoendoscopy. [39][40][41][42][43][44][45][46] Because this is a screening examination by a minimally invasive technique, from a clinical point of view it only makes sense to perform it in patients who have been previously treated with curative intent for their primary tumor. For the diagnosis of SCC, five of the studies showed improvements in the rates of diagnosis, mostly for early cancers, ranging from 20-100% of detected lesions, 39,41,42,45,46 while all eight studies showed increased yield for dysplasia ranging from 33-100% of lesions.…”