Luftverschmutzung und atopisches Ekzem

Krämer, Ursula; Behrendt, Heidrun

doi:10.1007/s00105-018-4330-3

Cited by 14 publications

(7 citation statements)

References 84 publications

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“…Several new studies have been published that were not included in this meta-analysis [54][55][56][57][58][59][60]. More recently, Krämer and co-workers have reviewed this evidence by combining data from 57 environmental epidemiological studies in a systematic review [61]. No sufficient evidence for a higher AE incidence upon large-scale exposure assessments of air pollution (PM 10 and sulfur dioxide (SO 2 )) was reported.…”

Section: Epidemiologymentioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

122

116

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Background: Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. Main text: To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health. Conclusion: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.

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Section: Epidemiologymentioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

122

116

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“…Ambient PM represents a global health risk, being implicated in various cardiovascular and pulmonary diseases, as well as cancers, with the smaller particle sizes being considered more dangerous due to their ability to travel deeper into internal systems. It is only recently that the role of PM in the development of skin conditions and skin aging characteristics has been questioned, with a number of studies indicating a correlation between air pollution levels and the increased onset of skin conditions and/or skin aging characteristics 4–6 . One such study observed a 20% increase in pigment spots on the cheeks and forehead with increased traffic‐associated PM exposure, while another study showed smokers were almost five times more likely to have facial wrinkles than nonsmokers 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Biological effects of air pollution on the function of human skin equivalents

Reynolds,

Eje,

Christensen

et al. 2023

FASEB BioAdvances

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The World Health Organization reports that 99% of the global population are exposed to pollution levels higher than the recommended air quality guidelines. Pollution‐induced changes in the skin have begun to surface; however, the effects require further investigation so that effective protective strategies can be developed. This study aimed to investigate some of the aging‐associated effects caused by ozone and particulate matter (PM) on human skin equivalents. Full‐thickness skin equivalents were exposed to 0.01 μg/μL PM, 0.05 μg/μL PM, 0.3 ppm ozone, or a combination of 0.01 μg/μL PM and 0.3 ppm ozone, before skin equivalents and culture medium were harvested for histological/immunohistochemical staining, gene and protein expression analysis using qPCR, Western blotting, and ELISA. Markers include MMP‐1, MMP‐3, COL1A1, collagen‐I, 4‐HNE, HMGCR, and PGE2. PM was observed to induce a decrease in epidermal thickness and an enhanced matrix building phenotype, with increases in COL1A1 and an increase in collagen‐I protein expression. By contrast, ozone induced an increase in epidermal thickness and was found to induce a matrix‐degrading phenotype, with decreases in collagen‐I gene/protein expression and increases in MMP‐1 and MMP‐3 gene/protein expression. Ozone was also found to induce changes in lipid homeostasis and inflammation induction. Some synergistic damage was also observed when combining ozone and 0.01 μg/μL PM. The results presented in this study identify distinct pollutant‐induced effects and show how pollutants may act synergistically to augment damage; given individuals are rarely only exposed to one pollutant type, exposure to multiple pollutant types should be considered to develop effective protective interventions.

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“…Allergic sensitizations in early childhood can act as eliciting or aggravating factors (atopic march) [4], which may continue in adulthood [5,6] and exert a major disease burden, impaired quality of life and individual suffering. AD is an environmentally induced and IgE-mediated disease in which the allergic inflammation is causing a disturbed skin barrier, and can be aggravated by colonization with Staphylococcus aureus [7], Malassezia species [8][9][10] and pollutants [11].…”

Section: Introductionmentioning

confidence: 99%

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

Badloe

Vriese

Coolens

et al. 2020

Clin Transl Allergy

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The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in disease progression and prolongation. These antibodies have been described in patients with severe and chronic AD, suggesting a progression from allergic inflammation to severe autoimmune processes against the skin. This review provides a summary of the current knowledge and gaps on IgE autoreactivity and self-reactive T cells in children and adults with AD based on a systematic search. Currently, the clinical relevance and the pathomechanism of IgE autoantibodies in AD needs to be further investigated. Additionally, it is unknown whether the presence of IgE autoantibodies in patients with AD is an epiphenomenon or a disease endotype. However, increased knowledge on the clinical relevance and the pathophysiologic role of IgE autoantibodies and self-reactive T cells in AD can have consequences for diagnosis and treatment. Responses to the current available treatments can be used for better understanding of the pathways and may shed new lights on the treatment options for patients with AD and autoreactivity against skin epitopes. To conclude, IgE autoantibodies and self-reactive T cells can contribute to the pathophysiology of AD based on the body of evidence in literature. However, many questions remain open. Future studies on autoreactivity in AD should especially focus on the clinical relevance, the contribution to the disease progression and chronicity on cellular level, the onset and therapeutic strategies.

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Luftverschmutzung und atopisches Ekzem

Cited by 14 publications

References 84 publications

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Biological effects of air pollution on the function of human skin equivalents

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

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