Luffariellolide, an anti-inflammatory sesterterpene from the marine spongeLuffariella sp.

Albizati, Kim F.; Holman, Theodore R.; Faulkner, D. John; Glaser, Keith B.; Jacobs, Robert S.

doi:10.1007/bf01951682

Cited by 80 publications

(76 citation statements)

References 7 publications

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“…Inasmuch as the paw edema was induced by the injection of PLA 2, it was anticipated that a PLA 2 inhibitor would effectively block the inflammatory response. Luffariellolide and aristolochic acid have been reported to be non-competitive in vitro inhibitors of PLA 2 [5,6]. Aristolochic acid was reported to inhibit human synovial fluid PLA2-induced mouse paw edema when coinjected [7].…”

Section: Discussionmentioning

confidence: 99%

Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse

Calhoun¹,

Yu²,

Sung³

et al. 1989

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Paw edema was produced in CD-1 mice by the injection of 0.3 micrograms of snake venom PLA2 (A.p. piscivorus D-49) into the hind paw. Edema peaked at 10 min, remained elevated until 60 min, and then declined slowly. The PLA2 inhibitors, luffariellolide and aristolochic acid, reduced the edema but only when coinjected with the PLA2. The histamine/serotonin antagonists were the most effective drug class against PLA2-induced paw edema. The PAF antagonists, CV-6202 (iv) and kadsurenone (coinjected) reduced the PLA2-induced edema, whereas high doses of the corticosteroids, dexamethasone and hydrocortisone, were also effective. NSAIDs only partially inhibited the paw edema. The LO/CO inhibitors yielded varying activities, with only BW755C and NDGA inhibiting the edema. These results suggest that PLA2 induces paw edema in the mouse via the action of several classes of inflammatory mediators.

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Section: Discussionmentioning

confidence: 99%

Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse

Calhoun¹,

Yu²,

Sung³

et al. 1989

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show abstract

“…The ability of manoalide to dissect these two components of the inflammation process may prove to be its most useful attribute in studying the role of Ca2+ signaling in inflammation and proliferation (e.g., Barzaghi et al, 1989). Luffariellolide (34), an analog of manoalide isolated from the same organism, also exhibited anti-inflammatory activity, was slightly less potent than manoalide, and was a partially reversible PLA 2 inhibitor (Albizati et al, 1987). Pseudopterosins A and E (35a,35b ), members of a family of diterpene ribosides isolated from the gorgonians Pseudopterogorgia bipinata and P. elisabethae, exhibit potent anti-inflammatory and analgesic activities and act as reversible inhibitors of lipoxygenase and PLA 2 (Luedke, 1990;Look et al, 1986).…”

Section: Anti-inflammatory/analgesic Compoundsmentioning

confidence: 98%

Biomedical Potential of Marine Natural Products

Ireland

Copp

Foster

et al. 1993

Pharmaceutical and Bioactive Natural Products

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“…Chemistry/bioactivity: the first specimen (from 1985) contained luffariellolide 120 as a major constituent comprising 14.5% by dry weight 86 and luffolide 121 as a minor metabolite. 87 In contrast, the second specimen (from 1995) contained three 9,11-secosterols, luffasterols A 122-C, as well as manoalide 123 and secomanoalide 124.…”

Section: Luffariella Spmentioning

confidence: 99%