Lues Maligna

Johnson, Russell; Spivak, Adam M.

doi:10.1093/ofid/ofx139

Cited by 10 publications

(5 citation statements)

References 10 publications

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“…2 Low CD4 may also favor MS, as most patients with HIV and MS have CD4 counts <500 cells/L. 1 However, there have been reported cases of MS in immunocompetent individuals, 3 as well as in HIV-positive individuals with normal CD4 counts, 4 as the patient described in the present case.…”

mentioning

confidence: 68%

Malignant syphilis in a patient with acquired human immunodeficiency virus (HIV) infection

Pereira

Lozada

Monteiro

2022

Anais Brasileiros de Dermatologia

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mentioning

confidence: 68%

Malignant syphilis in a patient with acquired human immunodeficiency virus (HIV) infection

Pereira

Lozada

Monteiro

2022

Anais Brasileiros de Dermatologia

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“…As in our patient, MS presents with severe unspecific prodromal systemic manifestations, which can be often attributed to other diseases, and a diagnosis of syphilis is overlooked. After a latent period, disseminated papules occur, which evolve to oval, well-demarcated ulceronecrotic crusted plaques, which can be grotesque and painful, and resemble the gummatous lesions seen in tertiary syphilis [ 9 , 10 ]. Most commonly affected are the skin of the trunk and extremities, but lesions can also erupt elsewhere, even on the mucous membranes [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The histopathological characteristics of MS can overlap with tertiary syphilis to some degree [ 9 , 10 ]. Histopathology in MS usually shows a dermal infiltrate with lymphocytes and plasma cells and sometimes granulomatous changes [ 14 ], as seen in our patient.…”

Section: Discussionmentioning

confidence: 99%

Malignant Syphilis in a Female Patient: A Case Report and Mini-Review

et al. 2022

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Malignant syphilis (MS) is a rare form of secondary syphilis with grotesque skin lesions, systemic manifestation and life-threatening complications. This article presents a case of MS in an immunocompetent 41-year-old female, who initially manifested with a generalized nonpruritic erythematous rash and systemic symptoms. She was mistreated for generalized impetigo and hepatitis attributed to chronic alcoholism. After partial recovery and a 3-month latent period, she developed infiltrated plaques with crusts on the trunk, head and neck; pharyngitis and laryngeal lesions; generalized lymphadenopathy and nonspecific systemic symptoms. Serologic tests confirmed syphilis, and cerebrospinal fluid analyses indicated the presence of anti-treponemal antibodies. Urine drug screening was positive for cannabinoids. The polymerase chain reaction from skin biopsy samples identified T. pallidum, confirmed with Warthin–Starry staining. Immunohistochemical analysis was uncharacteristic. Tertiary syphilis, neurosyphilis, ocular syphilis and otosyphilis were excluded. However, the patient was treated for neurosyphilis with benzylpenicillin (18 million IU intravenously daily, 14 days) and corticosteroids. No Jarisch–Herxheimer reaction occurred. Ten months after treatment, residual scars were visible, and 1 year later, she attempted suicide. Since MS can resemble other diseases, it should be suspected in a mentally ill patient with chronic drug abuse, systemic nonspecific manifestations and dermatological abnormalities, including the head and neck region.

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“…Clinically, MS lesions start as polymorphous papules that evolve into nodules, pustules, typically ulcers and are sometimes covered by a rupioid crust. 11 In addition, MS typically involves the trunk and extremities, 11 but barely the head and neck. 12 Associated systemic symptoms are common, such as fever and arthralgia, myalgia, headache and photophobia.…”

Section: Discussionmentioning

confidence: 99%

Malignant syphilis in a young woman: A case report

2022

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Malignant syphilis (MS) is a rare dermatological manifestation of secondary syphilis. This case report describes a young woman that presented with a 15-day history of generalized condyloma lata and seborrheic dermatitis-like lesions at various stages. Laboratory tests showed a toluidine red unheated serum test titre of 1:128 and Treponema pallidum particle agglutination positivity. Serology for HIV antibodies was repeatedly negative. MS was diagnosed according to established MS diagnostic criteria. The lesions regressed after treatment with 2 400 000 units penicillin G benzathine by intramuscular injection weekly for three consecutive weeks. MS is more frequently associated with HIV-infected patients, which makes this current case more interesting because MS in HIV-negative patients has rarely been reported.

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Lues Maligna

Cited by 10 publications

References 10 publications

Malignant syphilis in a patient with acquired human immunodeficiency virus (HIV) infection

Malignant syphilis in a patient with acquired human immunodeficiency virus (HIV) infection

Malignant Syphilis in a Female Patient: A Case Report and Mini-Review

Malignant syphilis in a young woman: A case report

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