Lucy wortham james award. Cytologic detection and diagnosis of cancer. Its contributions and limitations

Christopherson, William M.

doi:10.1002/1097-0142(19830401)51:7<1201::aid-cncr2820510706>3.0.co;2-9

Cited by 29 publications

(5 citation statements)

References 20 publications

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“…Despite the experience of other specialties,9 diagnostic and therapeutic fine needle aspiration of cysts has never been widely accepted in gynaecology because of the fear of spreading malignant cells in case of unrecognised malignancy and because of the low sensitivity of cytology 10 11 12 13 14 15. However, in the last decade increased accuracy of ultrasonography has allowed non-malignant benign cysts to be identified reliably 3 16.…”

Section: Introductionmentioning

confidence: 99%

Role of puncture and aspiration in expectant management of simple ovarian cysts: a randomised study

Zanetta

Lissoni

Torri

et al. 1996

BMJ

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Objectives-To assess the potential of expectant management for simple ovarian cysts diagnosed by transabdominal or transvaginal ultrasonography. To compare the results of needle aspiration with those achieved with simple observation.Design-Randomised trial. Setting-Hospital department of obstetrics and gynaecology.Subjects-278 women with simple cysts randomly allocated to simple observation (143) or ultrasound guided fine needle aspiration (135) between 1990 and 1994.Main outcome measures-Resolution of cyst or development of malignancy.Results-After six months 269 were available for follow up. The rate of resolution was 46% (59/128) with aspiration and 44.6% (63/141) with observation. Only the diameter of the cyst (P<0.0001) was a significant independent prognostic factor for resolution in a multivariate analysis. Age and treatment had no significant effect. One woman was subsequently found to have borderline malignant changes on histopathological examination. Her cyst was detected by transabdominal ultrasonography.Conclusions-Expectant management for up to six months does not cause risks for the patients and allows spontaneous resolution in over a third of cases, avoiding the costs and risks of unnecessary surgery. Aspiration does not provide better results than simple observation IntroductionA large study performed in 1989 by Campbell et al on more than 5000 healthy women found that roughly 6% had adnexal masses, 90% of which were cystic tumours.' Grimes and Hughes reported that ovarian

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Section: Introductionmentioning

confidence: 99%

Role of puncture and aspiration in expectant management of simple ovarian cysts: a randomised study

Zanetta

Lissoni

Torri

et al. 1996

BMJ

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“…A recent resurgence of interest in this technique has aroused fears that it may be overused and, in the hands of less experienced pathologists, could lead to serious errors in diagnosis with disastrous consequences. [1][2][3][4][5] The difficulty arises from the fact that this technique provides a cytologic diagnosis which, in the opinion of many pathologists, should not be used as a basis for initiating radical treatment such as surgery or chemotherapy. The general practice has been to obtain a histologic confirmation of the FNAB diagnosis prior to instituting definitive therapy.…”

Section: Discussionmentioning

confidence: 99%

“…This raises serious doubts about the value of FNAB as a diagnostic technique. [2][3][4][5] One way to obviate this difficulty may be to use FNAB as a combined cytologic and histologic technique. 6,7 This is accomplished by submitting part of the FNAB sample for a cell block examination.…”

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confidence: 99%

Role of Cell Block in The Interpretation of Fine-Needle Aspiration Biopsies

1988

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This study is based on a retrospective analysis of 210 fine-needle aspiration biopsies in which both cytology smears and paraffin cell blocks were available. The histology slides from these cell blocks were reviewed, and the cases were subdivided into three categories. In category A, which included 118 (56%) cases, a definitive histologic diagnosis of the presence as well as type of the cancer could be made. In category B, including 56 (27%) of cases, only the presence of cancer could be ascertained, but the type could not be defined. In category C, which consisted of 36 (17%) cases, the tissue was insufficient for reliable diagnosis. Carcinomas were most likely to have cell blocks in category A (65%) as compared to sarcomas (28%) or lymphomas (9%). Comparison of the cytologic diagnosis based on aspiration smears with the cell block diagnosis revealed that in 6% of cases only cell block was positive, while in another 8% of cases the diagnosis from the cell block was more precise and specific. These results indicate that cell blocks can enhance the effectiveness of fine-needle aspiration biopsy in establishing a pathologic diagnosis of cancer. 1 This technique has the advantage over other forms of biopsies because it is reliable, rapid, inexpensive, and relatively painless. Although FNAB is now accepted universally as an important initial step for investigating a patient with a clinically suspicious mass, there are still significant difficulties in using this technique to establish a definitive pathologic diagnosis of cancer. Therefore, in many cases, FNAB is followed by a confirmatory histologic biopsy prior to instituting radical therapy. This raises serious doubts about the value of FNAB as a diagnostic technique. 2-5One way to obviate this difficulty may be to use FNAB as a combined cytologic and histologic technique. 6,7 This is accomplished by submitting part of the FNAB sample for a cell block examination. This study was undertaken to evaluate the feasibility of making a definitive histologic diagnosis based on the examination of cell blocks prepared from FNAB samples.

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“…Fine needle aspiration biopsy helps in confirming a clinical suspicion of local recurrence or metastasis of known cancer without subjecting the patient to further surgical intervention. [1]…”

Section: Introductionmentioning

confidence: 99%

FNAB of metastatic lesions with special reference to clinicopathological analysis of primary site in cases of epithelial and non-epithelial tumors

Ahmad

Akhtar

Singh

et al. 2011

J Cytol

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Aims:To ascertain the cytological diagnosis of metastatic lesions with special reference to the clinicopathological analysis of the primary site in cases of epithelial and non-epithelial tumors.Materials and Methods:One hundred seventy-one suspected metastatic lesions were aspirated with a 22-23G needle and the smears were fixed and stained. The cases in which the primary site was not evident at the time of initial presentation were subsequently subjected to thorough physical examination followed by radiological investigations for the search of the primary site. Histopathological examination was performed in 16 cases with inconclusive cytological impression.Observations:Of the total cases of metastatic lesions, 155 cases (90.6%) were diagnosed by fine needle aspiration biopsy and 16 cases (9.4%) by histopathology. The majority of the cases, 81 (47.4%), were observed in the fifth decade of life, followed by 76 cases (44.4%) in the sixth decade and 11 cases (6.4%) in the seventh decade of life. Lymph nodes were the most frequent site of metastasis in 115 cases (67.3%), with the majority in the cervical group. The oropharynx, including the oral cavity and pharyngolarynx, was observed to be the most common primary site, 55 cases (32.2%).Conclusion:The most critical aspect of the evaluation of metastatic cases is the accurate pathologic assessment of the malignant tissues in conjunction with pertinent clinical data. Such close collaboration between the clinician and the pathologist may maximize the diagnostic potential in treatable primary tumors.

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Lucy wortham james award. Cytologic detection and diagnosis of cancer. Its contributions and limitations

Cited by 29 publications

References 20 publications

Role of puncture and aspiration in expectant management of simple ovarian cysts: a randomised study

Role of puncture and aspiration in expectant management of simple ovarian cysts: a randomised study

Role of Cell Block in The Interpretation of Fine-Needle Aspiration Biopsies

FNAB of metastatic lesions with special reference to clinicopathological analysis of primary site in cases of epithelial and non-epithelial tumors

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