Lucky to meet RS3PE

Ferrão, Cláudia; Faria, Raquel; Farrajota, Pedro; Vasconcelos, Carlos

doi:10.1136/bcr-2013-010363

Cited by 11 publications

(10 citation statements)

References 15 publications

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“…14 The other patient responded only partially to steroids but complete remission was achieved 4 days after surgical treatment of cancer. 15 We also report a similar finding in two patients with prostate adenocarcinoma with RS3PE. The first patient did respond…”

Section: Standard Treatment and Case-specific Treatment Strategies Fo...supporting

confidence: 77%

“…In our analysis, we found associations of RS3PE with certain malignancies such as lung cancer, adenocarcinoma of the prostate, myelodysplastic syndrome, adenosquamous lung carcinoma. [14][15][16][17][18] A thorough clinical investigation, a strong clinical suspicion and awareness associations of the musculoskeletal syndromes associated with tumor entities is of utmost importance in diagnosing paraneoplastic rheumatological diseases such as RS3PE. 28 Hence, clinicians should be actively aware of the association of malignancies and the selective influence of tumors on the musculoskeletal tissue through alteration of the periosteum, synovial membrane, subcutaneous connective tissue, fascia, muscles and bones.…”

Section: Rs3pe Associated With Cancersmentioning

confidence: 99%

See 1 more Smart Citation

Remitting Seronegative Symmetrical Synovitis with Pitting Edema: A Review

Lakhmalla

Dahiya

Kichloo

et al. 2021

Journal of Investigative Medicine

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Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare benign rheumatological condition characterized by sudden-onset symmetrical distal extremity edema. It can present as an isolated disease process or could be associated with other conditions. Rheumatoid factor and anticitrullinated protein antibodies are negative by definition. In current literature, there is paucity of data about the disease process. We performed a literature search using the PubMed database to identify 38 articles that met our inclusion and exclusion criteria. Our literature review focuses on the clinical picture and its diverse associations. Role of various acute phase reactants has also been outlined. There is a generalized consensus among clinicians on using moderate dose steroids for treatment. Other management options for refractory cases have also discussed. Value of several imaging modalities in diagnostic evaluation of this disease entity is touched on. Since RS3PE can be associated with other diseases, specifically cancer, timely diagnosis of this condition is necessary.

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Section: Standard Treatment and Case-specific Treatment Strategies Fo...supporting

confidence: 77%

Section: Rs3pe Associated With Cancersmentioning

confidence: 99%

Remitting Seronegative Symmetrical Synovitis with Pitting Edema: A Review

Lakhmalla

Dahiya

Kichloo

et al. 2021

Journal of Investigative Medicine

View full text Add to dashboard Cite

show abstract

“… 22 , 23 Ferrao demonstrated resolution of symptoms of RS3PE in a patient after removal of a lung mass. 24 Sakamoto et al published a case study that showed that even without complete remission of the malignancy, chemotherapy led to improvements in symptoms of RS3PE. 25 …”

Section: Discussionmentioning

confidence: 99%

Case Report: Syndrome of Remitting Seronegative Symmetrical Synovitis with Pitting Edema—A Rare but Treatable Condition in Palliative Medicine

Moore

Brouner

Grigorian

et al. 2022

Palliative Medicine Reports

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The syndrome of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare diagnosis that is often missed due to lack of both definitive diagnostic criteria and awareness of the disease. This case report describes a patient with chronic lymphocytic leukemia whose diagnosis of RS3PE was possibly delayed due to concomitant treatment-related arthralgias. The pathophysiology, presentation, and treatment of RS3PE are discussed. Greater awareness of malignancy-related RS3PE is crucial from a palliative care perspective as typical opioid pain management will prove ineffective and delay appropriate treatment.

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“…A poor response to low or moderate dose corticosteroids of up to 20 mg of prednisolone a day has been reported as concerning for malignancy as benign RS3PE typically responds to steroid treatment within 24–48 hours of therapy 4 11. In cases with a proven malignancy, definitive treatment of RS3PE is targeted at the management of the underlying cancer 4 22 23…”

Section: Discussionmentioning

confidence: 99%

Remitting seronegative symmetric synovitis with pitting edema (RS3PE) with painful erythematous nodules

Laidler

Delaney

2020

BMJ Case Rep

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Remitting seronegative symmetric synovitis with pitting edema (RS3PE) is an uncommon syndrome characterised by acute onset severe synovitis of the radiocarpal and small joints of the hands, with associated pitting edema. Discussed here is the case of a 69-year-old man who presented to the emergency department of a tertiary hospital with acute bilateral hand swelling. This was on a background of a recent diagnosis of metastatic adenocarcinoma of the caecum and subsequent hemicolectomy. There was a history of general malaise, fever and lethargy for 5 days prior to the swelling of the hands. On examination, the upper limbs were swollen to the elbow bilaterally. Painful erythematous nodules were noted on the dorsal and palmar aspects of the hands and violaceous periungual discolouration was observed on the right fourth and fifth fingers. Prednisolone was commenced resulting in a dramatic resolution of the articular and cutaneous manifestations within 3 weeks.

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Lucky to meet RS3PE

Cited by 11 publications

References 15 publications

Remitting Seronegative Symmetrical Synovitis with Pitting Edema: A Review

Remitting Seronegative Symmetrical Synovitis with Pitting Edema: A Review

Case Report: Syndrome of Remitting Seronegative Symmetrical Synovitis with Pitting Edema—A Rare but Treatable Condition in Palliative Medicine

Remitting seronegative symmetric synovitis with pitting edema (RS3PE) with painful erythematous nodules

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