Lucio’s phenomenon: A report on six patients in a tertiary referral hospital in Indonesia

Marissa, Melani; Rihatmadja, Rahadi; Surya, Danny; Lim, Henry W.; Menaldi, Sri Linuwih

doi:10.19100/jdvi.v5i1.225

Cited by 2 publications

(11 citation statements)

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“…Then the lesion has erosion and becomes an ulcerated irregular shape with central necrosis surrounded by hyperpigmentation area which may be accompanied by pain and secondary infection. Lesions are usually found in extremities and rarely affecting the face and trunk [3][4][5][6] . The skin necrosis without vesicles or ulcers is unusual, only 3 out of 12 patients with LP.…”

Section: Casementioning

confidence: 99%

“…It was first reported by Lucio and Alvarado in 1852 in Mexico as diffuse necrotic skin lesions in patients with non-nodular lepromatous leprosy. In 1948, Latapi and Zamora named Lucio's phenomenon for this reaction after finding histopathologic features vasculitis and skin necrosis in the same type of leprosy [2][3][4][5] . LP are commonly found in Mexico and Central America, but several cases have also been reported in United States, Peru, Hawaii, Brazil, India, Malaysia, and Indonesia [2][3][4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

“…In 1948, Latapi and Zamora named Lucio's phenomenon for this reaction after finding histopathologic features vasculitis and skin necrosis in the same type of leprosy [2][3][4][5] . LP are commonly found in Mexico and Central America, but several cases have also been reported in United States, Peru, Hawaii, Brazil, India, Malaysia, and Indonesia [2][3][4][5][6][7][8][9] . Although Indonesia is a leprosy endemic region and the 3rd highest leprosy cases in the world with 17.439 cases in 2019, LP still rarely reported.…”

Section: Introductionmentioning

confidence: 99%

“…Although Indonesia is a leprosy endemic region and the 3rd highest leprosy cases in the world with 17.439 cases in 2019, LP still rarely reported. 10 LP is defined as a type 2 variant of leprosy reaction [2,5,7,9] . LP often occurrence patients with diffuse non-nodular leprosy or Lepromatous Leprosy (LL) and Borderline Leprosy (BL) who do not receive or complete a leprosy treatment [2][3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

“…10 LP is defined as a type 2 variant of leprosy reaction [2,5,7,9] . LP often occurrence patients with diffuse non-nodular leprosy or Lepromatous Leprosy (LL) and Borderline Leprosy (BL) who do not receive or complete a leprosy treatment [2][3][4][5][6] . We reported the first case of LP in East Lombok Regency, West Nusa Tenggara in a patient who had never been diagnosed with leprosy.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse multibacillary leprosy with Lucio’s phenomenon in east Lombok, west Nusa Tenggara, Indonesia

Widjaya¹,

Mariam²

2021

Int. J. Dermatol. Venereology Leprosy Sci.

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Introduction: Lucio's phenomenon (LP) is a rare leprosy reaction characterized by severe necrosis of the skin. LP is a variant of type II leprosy reaction by the involvement of immune complexes. LP is usually found in Mexico and Central America. This reaction is especially found in diffuse non-nodular lepromatous leprosy who have not received or completed leprosy treatment. Case: A 36 years woman with newly diagnosed Lucio's phenomenon after initially being misdiagnosed with fungal infection for several months. Discussion: In clinically, LP may mimic other diseases such as mycosis and allergic reaction. Until now there is no consensus regarding LP treatment and combination MDT-MB and systemic corticosteroids are the options in this case. Conclusion: A proper history, physical examination, and histopathology are important diagnostic approaches to avoid misdiagnosis or underdiagnosis in LP cases especially in leprosy endemic regions. The combination of MDT-MB and systemic corticosteroids in FL gives a good response.

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Section: Casementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diffuse multibacillary leprosy with Lucio’s phenomenon in east Lombok, west Nusa Tenggara, Indonesia

Widjaya¹,

Mariam²

2021

Int. J. Dermatol. Venereology Leprosy Sci.

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Rare Variant of Leprosy Reaction (Lucio Phenomenon): A Case Series

Rusyati,

Saputra,

Indah

et al. 2024

The International Journal of Mycobacteriology

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Lucio phenomenon (LP) is a variant of type two leprosy, characterized by necrotizing erythema, frequently found in neglected leprosy patient who experience delayed diagnosis or inappropriate treatment. Indonesia is in the third place for highest leprosy cases worldwide. Nonetheless, LP is less common, regardless being an endemic country. In this serial case, we describe the three cases of LP in lepromatous leprosy patients in Denpasar, Bali. All three cases came to our hospital with chronic wounds complained up to a year, accompanied by swollen leg, blisters, tingling sensation, and other symptoms. They had received no suitable treatment, proving LP as a neglected case in primary health care. After a period of treatment, however, patient lesions improved clinically with no physical disability. With this case series, a better understanding toward LP initial complains together with its natural history and further examination could be achieved; thus, improving the early diagnosis and management of LP.

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Lucio’s phenomenon: A report on six patients in a tertiary referral hospital in Indonesia

Cited by 2 publications

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Diffuse multibacillary leprosy with Lucio’s phenomenon in east Lombok, west Nusa Tenggara, Indonesia

Diffuse multibacillary leprosy with Lucio’s phenomenon in east Lombok, west Nusa Tenggara, Indonesia

Rare Variant of Leprosy Reaction (Lucio Phenomenon): A Case Series

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