Luciferin-based fluorescent hydrogel as a pH sensor

Abstract

Hydrogel have been a great material for biomedical applications. In this study, fluorescent hydrogels formulated from carrageenan biopolymers and firefly luciferin, exhibited high fluorescence quantum yield and stability, thermo-reversibility, and high transparency.Importantly, the hydrogels are pH-responsive which allow them to be used as sensing materials for a range of pH from 3 to 6.5. The hydrogels may find potential applications as cheap and tailored materials in photodynamic therapy (i.e., pH sensor for wound healing, bioluminescence hydrogels for cell study).

Application of Optical Fiber Sensing Technology and Coating Technology in Blood Component Detection and Monitoring

“…Most pH sensors are based on the use of coating materials with PH-sensitive optical properties, with indicator dyes [82] and hydrogels [83,84] being the most commonly used coating materials for pH sensors. This fluorescence-based fiber-optic sensor (FF) structure, in which a reversible indicator system (colorimetric or fluorescent) is fixed at the fiber end, is attractive because of the large number of indicators that can be used for detection [85][86][87].…”

Unraveling the contributions to the spectral shape of flexible dyes in solution: insights on the absorption spectrum of an oxyluciferin analogue

“…1). Besides its biological and technological relevance, [44][45][46][47] this system was chosen to evaluate the performance of MQC approaches in a case where several low lying close electronic excited states are responsible for the observed spectral signature. The aim is to provide a simulation where the main contributions to the spectral shape are analysed from first principles, allowing us to unravel the role of each effect concurring to the broadening.…”