Lubrication potential of magnesium stearate studied on instrumented rotary tablet press

Patel, Sarsvatkumar; Kaushal, Aditya Mohan; Bansal, Arvind K.

doi:10.1208/pt0804089

Cited by 40 publications

(8 citation statements)

References 23 publications

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“…6,50 Finally, the effect of MgSt on the ejection force revealed the impact of the lubricating properties of MgSt. 51 The reduction in EF induced by MgSt was similar for all formulations and all paddle speeds. The desired effect (i.e.…”

Section: Effect Of the Paddle Speedsmentioning

confidence: 79%

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Peeters

Vanhoorne

Remon

2016

Drug Development and Industrial Pharmacy

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To refer to or to cite this work, please use the citation to the published version: Peeters E., Vanhoorne V., Vervaet C., Remon J.P. AbstractContext: The negative impact of magnesium stearate on the hardness of tablets is a wellknown phenomenon, but the influence of paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected.Objective: The purpose of this research was to investigate the influence of paddle speed in the forced feeder on tablet tensile strength. Materials and methods:Mixtures of microcrystalline cellulose and magnesium stearate (0.5%)were blended using different methods (low & high shear). After blending, the formulations were compressed into tablets. All parameters of the tableting cycle were kept constant except the speed of the paddles in the forced feeder. Results and discussion:The blending technique affected the sensitivity of the formulation to the paddle speed. The tensile strength of pure microcrystalline cellulose tablets didn't change in function of paddle speed, while tablets prepared by low shear mixing became softer at higher paddle speed. The tensile strength of tablets manufactured using the high-shear mixed blend was low and didn't vary in function of paddle speed, suggesting that overlubrication already occurred during the initial blending step. Furthermore, analysis of the machine parameters allowed evaluation of the influence of the paddles on the flowability, initial packing and compactability of the powder mixtures. Conclusion:The results elucidated that during manufacturing of tablets using magnesium stearate-containing blends care should not only be taken during the blending step prior to tableting, but also during the tableting process itself, as paddle speed can affect tablet tensile strength, a critical quality attribute.

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Section: Effect Of the Paddle Speedsmentioning

confidence: 79%

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Peeters

Vanhoorne

Remon

2016

Drug Development and Industrial Pharmacy

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“…This explains the increasing amount of elastic work shown in the igure for the whole samples, especially to Flowlac 100. When the applied pressure increase, the stored elastic work will directly increase (Patel et al, 2007).…”

Section: Elastic Workmentioning

confidence: 99%

Compaction behaviour and mechanical characteristics of chewable binary tablet mixture containing lactose (Flowlac 100) and date (Phoenix dactylifera) powders

Hamidi

Anuar

Baharuddin

et al. 2019

ijrps

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This study aimed to develop a formulation for a chewable tablet using date powder (DP) and Flowlac 100 utilizing a direct compression method. The powders were compacted as single and binary mixtures at five different formulations (DPL1, DPL2, DPL3, DPL4 and DPL5) to study their compaction behaviour. Stressor ranging from 15 to 74 MPa in a cylindrical die with flat face punches were introduced during the fabrication process, and the mechanical properties (plastic work, flexible work and tensile strength) of formed tablets were investigated. Findings of this study demonstrated that with a high percentage of DP in the formulation resulted in a high reading of plastic work, while a low amount of DP revealed low elastic work. Tensile strength of the tablet, on the other hand, varies with the percentage of DP present and applied pressure used. Formulation with 60% DP (DPL4) displayed the highest tensile strength compared to the other formulations, and it is coherent with industrial preferable tensile strength limit. In conclusion, the current findings could be useful in formulation and fabricating date chewable tablet which can be used as a food supplement by all categories of consumers since it is easy to be consumed by a wide range of age.

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“…[23] Introduction of the high-speed tableting machine requires the use of higher concentrations of Magnesium Stearate, but increasing concentration of Magnesium Stearate can adversely affect the flow properties of the tableting mass and the quality properties of tablets. [24,25,26] In the next few sections, our focus will center on the effect of magnesium stearate on the manufacturing process and product performance. w/w), lactose monohydrate (22%, w/w), and acetaminophen (5%, w/w).…”

Section: (Ii) Boundary Lubricationmentioning

confidence: 99%

Lubricants in Pharmaceutical Solid Dosage Forms With Special Emphasis on Magnesium Stearate

Kanher¹

2017

WJPR

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Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage form; lubricants are essential ingredients in robust formulation to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in general, lubricants do not gain adequate attention in the development of pharmaceutical formulations. The addition of lubricants also affect tablet properties and can affect the behaviour of the powder mixture. In this review, the fundamental background on lubrication is introduced, in which the relationships between lubrication and friction/adhesion forces are discussed. The application of lubrication in the development of pharmaceutical products and manufacturing processes is discussed with an emphasis on magnesium stearate. In particular, the effect of hydration state (anhydrate, monohydrate, dihydrate, and trihydrate) of a lubricant like Magnesium stearate and its powder characteristics on lubricant efficiency, as well as product and process performance is summarized.KEYWORD: lubricant, magnesium stearate, efeect of lubricant on tablet properties.

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Lubrication potential of magnesium stearate studied on instrumented rotary tablet press

Cited by 40 publications

References 23 publications

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Compaction behaviour and mechanical characteristics of chewable binary tablet mixture containing lactose (Flowlac 100) and date (Phoenix dactylifera) powders

Lubricants in Pharmaceutical Solid Dosage Forms With Special Emphasis on Magnesium Stearate

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