Sedation during colonoscopy and the benefits of lubrication SIRS, We read with great interest the study by Leung et al. Moreover, important additional factors are, in our opinion, substances and methods of lubrications, rarely considered by endoscopists, 6 although favourable effects have been demonstrated. [7][8][9] In this respect, it is noteworthy that a warm water infusion through the instrument was carried out during colonoscopy in the study by Leung et al.1 Lubricating methods and substances, reducing friction between the scope and the colonic mucosa, may substantially help in performing examinations. This view is also supported by the results of a prospective, randomized-controlled trial that we recently performed, 10 in which two lubricating methods (i.e. an oil-assisted and a warm water technique) were compared with each other and vs. a control group. These simple, safe and inexpensive methods allowed us to improve the completion rates of colonoscopy and also reduced pain and difficulties during the examination; furthermore, as examinations were started without intravenous drugs (only if substantial pain or remarkable technical difficulties occurred, sedation was performed), we were able to show that, using such lubricating methods, the rate of patients in which intravenous medications were needed, was lower when compared with patients in which lubricating techniques were not adopted. Thus, our results are in agreement with those by Leung et al.