Lubricating MXenzyme-based hybrid hydrogel reverses oxidative damage to alleviate osteoarthritis

Zhang, Zhao; Cheng, Debin; Pan, Jingxin; Liu, Dong; Fu, Jun; Fan, Hongbin

doi:10.1016/j.cej.2024.148815

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…Adding lubricating components to the hydrogel, such as hyaluronic acid, nanoparticles, phospholipids (PC), − etc., can effectively improve the lubricating performance. Among them, PC are amphiphilic molecules composed of two hydrophobic tail groups and one hydrophilic phosphatidylcholine headgroup, which form double molecular layers called liposomes through self-assembly.…”

Section: Introductionmentioning

confidence: 99%

Cartilage-Inspired, High-Strength, and Heat-Tolerant Lubricating Hydrogels by Macrophase Separation

Yang,

You,

Deng

et al. 2024

Biomacromolecules

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Hydrogels are considered as a potential cartilage replacement material based on their structure being similar to natural cartilage, which are of great significance in repairing cartilage defects. However, it is difficult for the existing hydrogels to combine the high load bearing and low friction properties (37 °C) of cartilage through sample methods. Herein, we report a facile and new fabrication strategy to construct the PNIPAm/EYL hydrogel by using the macrophase separation of supersaturated N-isopropylacrylamide (NIPAm) monomer solution to promote the formation of liposomes from egg yolk lecithin (EYL) and asymmetric template method. The PNIPAm/EYL hydrogels possess a relatively high compressive strength (more than 12 MPa), fracture energy (9820 J/m2), good fatigue resistance, lubricating properties, and excellent biocompatibility. Compared with the PNIPAm hydrogel, the friction coefficient (COF 0.046) of PNIPAm/EYL hydrogel is reduced by 50%. More importantly, the COF (0.056) of PNIPAm/EYL hydrogel above lower critical solution temperature (LCST) does not increase significantly, exhibiting heat-tolerant lubricity. The finite element analysis further proves that PNIPAm/EYL hydrogel can effectively disperse the applied stress and dissipate energy under load conditions. This work not only provides new insights for the design of high-strength lubricating hydrogels but also lays a foundation for the treatment of cartilage injury as a substitute material.

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