LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)

Maggi, Laura; Trettel, Flavia; Scianni, Maria; Bertollini, Cristina; Eusebi, Fabrizio; Fredholm, Bertil B.; Limatola, Cristina

doi:10.1016/j.jneuroim.2009.07.016

Cited by 79 publications

(70 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, Maggi and colleagues have used fEPSP recordings at the Schaffer collaterals synapse to reveal that fractalkine significantly inhibits long-term potentiation (LTP) when administered during the critical period for induction, in acute slices from 6–8 weeks old wild-type mice. This impairment of LTP was however absent in slices from CX 3 CR1 KO/KO mice, and additionally found to require the activation of AR3 receptors as it was prevented by the selective antagonist MRS1523 (Maggi et al, 2009), in agreement with the previous findings. Nevertheless, subsequent studies using CX 3 CR1 KO/KO mice to explore the effects of fractalkine signaling on long-term plasticity, in acute slices from the hippocampus CA1 region, reported a complete absence of LTP (Rogers et al, 2011), or a more sustained LTP than in wild-type littermates, when LTP was induced by a weak stimulation protocol (Maggi et al, 2011).…”

Section: Consequences Of Fractalkine On Neuronal Circuit Function Andsupporting

confidence: 89%

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

Paolicelli¹,

Bisht²,

Tremblay³

2014

Front. Cell. Neurosci.

262

243

View full text Add to dashboard Cite

Neural circuits are constantly monitored and supported by the surrounding microglial cells, using finely tuned mechanisms which include both direct contact and release of soluble factors. These bidirectional interactions are not only triggered by pathological conditions as a S.O.S. response to noxious stimuli, but they rather represent an established repertoire of dynamic communication for ensuring continuous immune surveillance and homeostasis in the healthy brain. In addition, recent studies are revealing key tasks for microglial interactions with neurons during normal physiological conditions, especially in regulating the maturation of neural circuits and shaping their connectivity in an activity- and experience-dependent manner. Chemokines, a family of soluble and membrane-bound cytokines, play an essential role in mediating neuron-microglia crosstalk in the developing and mature brain. As part of this special issue on Cytokines as players of neuronal plasticity and sensitivity to environment in healthy and pathological brain, our review focuses on the fractalkine signaling pathway, involving the ligand CX3CL1 which is mainly expressed by neurons, and its receptor CX3CR1 that is exclusively found on microglia within the healthy brain. An extensive literature largely based on transgenic mouse models has revealed that fractalkine signaling plays a critical role in regulating a broad spectrum of microglial properties during normal physiological conditions, especially their migration and dynamic surveillance of the brain parenchyma, in addition to influencing the survival of developing neurons, the maturation, activity and plasticity of developing and mature synapses, the brain functional connectivity, adult hippocampal neurogenesis, as well as learning and memory, and the behavioral outcome.

show abstract

Section: Consequences Of Fractalkine On Neuronal Circuit Function Andsupporting

confidence: 89%

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

Paolicelli¹,

Bisht²,

Tremblay³

2014

Front. Cell. Neurosci.

262

243

View full text Add to dashboard Cite

show abstract

“…Ex vivo manipulations demonstrated that administration of fractalkine inhibits LTP induction. This effect was not found in CX 3 CR1ko mice (Maggi et al, 2009). Oppositely, Rogers and collaborators reported complete absence of LTP ex vivo in CX 3 CR1ko mice (Rogers et al, 2011).…”

Section: Microglia Role In Synaptic Activitymentioning

confidence: 87%

Microglia in neuronal plasticity: Influence of stress

et al. 2015

View full text Add to dashboard Cite

“…More direct, genetic evidence that microglia could be playing roles in baseline behavior include work in CX3CR1-deficient mice, which have deficits in long-term potentiation accompanied by significant deficits in contextual fear learning and performance in the Morris water maze (Rogers et al 2011). However, another study found the opposite result, with very little effect on behavioral performance (Maggi et al 2009). This may be attributed to differences in paradigms used for behavioral measurements in the two studies.…”

Section: Behavioral Effects In the Healthy Cnsmentioning

confidence: 97%

Microglia Function in Central Nervous System Development and Plasticity

Schafer

Stevens

2015

Cold Spring Harb Perspect Biol

300

259

View full text Add to dashboard Cite

The nervous system comprises a remarkably diverse and complex network of different cell types, which must communicate with one another with speed, reliability, and precision. Thus, the developmental patterning and maintenance of these cell populations and their connections with one another pose a rather formidable task. Emerging data implicate microglia, the resident myeloid-derived cells of the central nervous system (CNS), in the spatial patterning and synaptic wiring throughout the healthy, developing, and adult CNS. Importantly, new tools to specifically manipulate microglia function have revealed that these cellular functions translate, on a systems level, to effects on overall behavior. In this review, we give a historical perspective of work to identify microglia function in the healthy CNS and highlight exciting new work in the field that has identified roles for these cells in CNS development, maintenance, and plasticity.

show abstract

LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)

Cited by 79 publications

References 47 publications

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

Microglia in neuronal plasticity: Influence of stress

Microglia Function in Central Nervous System Development and Plasticity

Contact Info

Product

Resources

About