&lt;title&gt;Thermoacoustic CT of the breast&lt;/title&gt;

Kruger, Robert A.; Stantz, Keith M.; Kiser, William L.

doi:10.1117/12.465596

Cited by 44 publications

(28 citation statements)

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“…After tests with phantom samples, such as a lamb kidney 65 or a porcine kidney, 102 they moved to clinical testing. 103,104 In this work, 104 they were able to visualize quite well most of the cysts that could be seen on ultrasound images; however, fibroadenomas could not be visualized except in the case of a fibroadenoma with associated atypical hyperplasia. The group attributed the lack of visualization of cancers to inadequate imaging quality, etc.…”

Section: Rf-based Imagingmentioning

confidence: 75%

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Photoacoustic imaging in biomedicine

Wang

2006

Review of Scientific Instruments

2,365

1,859

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Photoacoustic imaging ͑also called optoacoustic or thermoacoustic imaging͒ has the potential to image animal or human organs, such as the breast and the brain, with simultaneous high contrast and high spatial resolution. This article provides an overview of the rapidly expanding field of photoacoustic imaging for biomedical applications. Imaging techniques, including depth profiling in layered media, scanning tomography with focused ultrasonic transducers, image forming with an acoustic lens, and computed tomography with unfocused transducers, are introduced. Special emphasis is placed on computed tomography, including reconstruction algorithms, spatial resolution, and related recent experiments. Promising biomedical applications are discussed throughout the text, including ͑1͒ tomographic imaging of the skin and other superficial organs by laser-induced photoacoustic microscopy, which offers the critical advantages, over current high-resolution optical imaging modalities, of deeper imaging depth and higher absorption contrasts, ͑2͒ breast cancer detection by near-infrared light or radio-frequency-wave-induced photoacoustic imaging, which has important potential for early detection, and ͑3͒ small animal imaging by laser-induced photoacoustic imaging, which measures unique optical absorption contrasts related to important biochemical information and provides better resolution in deep tissues than optical imaging.

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Section: Rf-based Imagingmentioning

confidence: 75%

“…They have designed several different versions of TCT systems. [101][102][103][104] At the beginning, they situated multiple single transducers on a spherical bowl to provide array detection. However, the calibration of a large number of transducers was difficult, so later they used an ultrasonic array with multiple elements.…”

Section: Rf-based Imagingmentioning

confidence: 99%

Photoacoustic imaging in biomedicine

Wang

2006

Review of Scientific Instruments

2,365

1,859

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“…In real-time free hand photoacoustic imaging, a part of the sample is visualised (Niederhauser 2004) and image reconstruction methods are necessary to obtain the spatial information out of the measured data. In full "photoacoustic tomography (PAT)", either a complete slice or the whole volume of the sample is reconstructed (Kruger et al 2002;Wang et al 2003). In the literature, several diVerent approaches to PAT imaging have been proposed [see (Xu and Wang 2006) for an up-to-date survey on existing methods].…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Molecular imaging with nanoparticles: giant roles for dwarf actors

Debbage

Jaschke

2008

Histochem Cell Biol

233

212

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Molecular imaging, first developed to localise antigens in light microscopy, now encompasses all imaging modalities including those used in clinical care: optical imaging, nuclear medical imaging, ultrasound imaging, CT, MRI, and photoacoustic imaging. Molecular imaging always requires accumulation of contrast agent in the target site, often achieved most efficiently by steering nanoparticles containing contrast agent into the target. This entails accessing target molecules hidden behind tissue barriers, necessitating the use of targeting groups. For imaging modalities with low sensitivity, nanoparticles bearing multiple contrast groups provide signal amplification. The same nanoparticles can in principle deliver both contrast medium and drug, allowing monitoring of biodistribution and therapeutic activity simultaneously (theranostics). Nanoparticles with multiple bioadhesive sites for target recognition and binding will be larger than 20 nm diameter. They share functionalities with many subcellular organelles (ribosomes, proteasomes, ion channels, and transport vesicles) and are of similar sizes. The materials used to synthesise nanoparticles include natural proteins and polymers, artificial polymers, dendrimers, fullerenes and other carbon-based structures, lipid-water micelles, viral capsids, metals, metal oxides, and ceramics. Signal generators incorporated into nanoparticles include iron oxide, gadolinium, fluorine, iodine, bismuth, radionuclides, quantum dots, and metal nanoclusters. Diagnostic imaging applications, now appearing, include sentinal node localisation and stem cell tracking.

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“…The generated thermoacoustic waves are then collected by ultrasonic transducers to reconstruct microwave specific absorption within the tissue. 1,2 Because malignant tissue and normal tissue differ substantially in their water content, their dielectric properties vary greatly. TAT, therefore, has the potential for application in tumor detection.…”

Section: Introductionmentioning

confidence: 99%

Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography

Jin

Wang

2008

Med. Phys.

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The effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography were studied. A numerical model for calculating the propagation of thermoacoustic waves through the skull was developed and experimentally examined. The model takes into account wave reflection and refraction at the skull surfaces and therefore provides improved accuracy for the reconstruction. To evaluate when the skull-induced effects could be ignored in reconstruction, the reconstructed images obtained by the proposed method were further compared with those obtained with the method based on homogeneous acoustic properties. From simulation and experimental results, it was found that when the target region is close to the center of the brain, the effects caused by the skull layer are minimal and both reconstruction methods work well. As the target region becomes closer to the interface between the skull and brain tissue, however, the skull-induced distortion becomes increasingly severe, and the reconstructed image would be strongly distorted without correcting those effects. In this case, the proposed numerical method can improve image quality by taking into consideration the wave refraction and mode conversion at the skull surfaces. This work is important for obtaining good brain images when the thickness of the skull cannot be ignored.

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<title>Thermoacoustic CT of the breast</title>

Cited by 44 publications

References 0 publications

Photoacoustic imaging in biomedicine

Photoacoustic imaging in biomedicine

Molecular imaging with nanoparticles: giant roles for dwarf actors

Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography

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