&lt;title&gt;Temperature dependence of optical properties of in-vivo human skin&lt;/title&gt;

Yeh, Su‐Ling; Khalil, Omar S.; Hanna, Charles F.; Kantor, Stan; Wu, Xiaomao; Jeng, Tzyy‐Wen; Bolt, René A.

doi:10.1117/12.434482

Cited by 15 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparisons of OTC methods may be valuable but are not easy because of differences in experimental setups and analysis methods [3,5,6,9,11,12,32,33,[37][38][39][40]. However, Izquierdo-Román et al reported that mechanical OTC methods are more effective about 2-3 fold than the chemical OTC method and achieve up to a 4-fold OTC increase [40], which is comparable to the 3.4-fold OTC increase of the combination OTC method.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Development of an Optical Tissue Clearing Laser Probe System

Yeo¹,

Kang²,

Bae³

et al. 2013

Journal of the Optical Society of Korea

View full text Add to dashboard Cite

Although low-level laser therapy (LLLT) has been a valuable therapeutic technology in the clinic, its efficacy may be reduced in deep tissue layers due to strong light scattering which limits the photon density. In order to enhance the photon density in deep tissue layers, this study developed an optical tissue clearing (OTC) laser probe (OTCLP) system which can utilize four different OTC methods: 1) tissue temperature control from 40 to 10℃; 2) laser pulse frequency from 5 to 30 Hz; 3) glycerol injection at a local region; and 4) a combination of the aforementioned three methods. The efficacy of the OTC methods was evaluated and compared by investigating laser beam profiles in ex-vivo porcine skin samples. Results demonstrated that total (peak) intensity at full width at half maximum of laser beam profile when compared to control data was increased: 1) 1.21(1.39)-fold at 10℃; 2) 1.22 (1.49)-fold at a laser pulse frequency of 5 Hz; 3) 1.64 (2.41)-fold with 95% glycerol injection; 4) 1.86 (3.4)-fold with the combination method. In conclusion, the OTCLP system successfully improved the laser photon density in deep tissue layers and may be utilized as a useful tool in LLLT by increasing laser photon density.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Thermal methods are based on the mechanism of gel/liquidcrystalline phase transitions of all lipids in human subdermis [7,8], modifications of collagen fiber structure in human dermis [9], degradation of cellular components [10], and variation of the refractive index of intercellular fluid [11]. Khalil et al.…”

Section: Introductionmentioning

confidence: 99%

Development of an Optical Tissue Clearing Laser Probe System

Yeo¹,

Kang²,

Bae³

et al. 2013

Journal of the Optical Society of Korea

View full text Add to dashboard Cite

show abstract

“…1) to generate a reference signal, which was used to correct for fluctuations in the intensity of the LEDs. A previously described optical system used up to six wavelengths and six source-detector distances that were varied sequentially through the use of stepper motor-controlled wheels (23,24 ). This optical system used a quadrant photodiode to allow simultaneous detection at four distances.…”

Section: Materials and Methods Instrumentmentioning

confidence: 99%

“…The wavelengths used were shorter than those reported in other studies (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and did not correspond to any glucose infrared absorption bands. Probe design allowed measurement of optical properties down to a depth of 2 mm in the skin, where temperature can be controlled and varied (23)(24)(25)(26).…”

Section: Noninvasive (Ni)mentioning

confidence: 99%

See 1 more Smart Citation

Monitoring Blood Glucose Changes in Cutaneous Tissue by Temperature-modulated Localized Reflectance Measurements

2003

Self Cite

View full text Add to dashboard Cite

Background: Most proposed noninvasive methods for glucose measurements do not consider the physiologic response of the body to changes in glucose concentration. Rather than consider the body as an inert matrix for the purpose of glucose measurement, we exploited the possibility that noninvasive measurements of glucose can be approached by investigating their effects on the skin's thermo-optical response. Methods: Glucose concentrations in humans were correlated with temperature-modulated localized reflectance signals at wavelengths between 590 and 935 nm, which do not correspond to any near-infrared glucose absorption wavelengths. Optical signal was collected while skin temperature was modulated between 22 and 38°C over 2 h to generate a periodic set of cutaneous vasoconstricting and vasodilating events, as well as a periodic change in skin light scattering. The method was tested in a series of modified meal tolerance tests involving carbohydrate-rich meals and no-meal or highprotein/no-carbohydrate meals. Results: The optical data correlated with glucose values. Changes in glucose concentrations resulting from a carbohydrate-rich meal were predicted with a model based on a carbohydrate-meal calibration run. For diabetic individuals, glucose concentrations were predicted with a standard error of prediction <1.5 mmol/L and a prediction correlation coefficient 0.73 in 80% of the cases. There were run-to-run differences in predicted glucose concentrations. Non-carbohydrate meals showed a high degree of scatter when predicted by a carbohydrate meal calibration model. Conclusions: Blood glucose concentrations alter thermally modulated optical signals, presumably through physiologic and physical effects. Temperature changes

show abstract

Dynamic change in optical properties of a nanoparticle embedded tumor phantom for plasmonic photothermal cancer therapeutics

Vikas

Kumar

Soni

2022

Journal of Biophotonics

View full text Add to dashboard Cite

In this study, the temporal dynamic changes in optical properties of gold nanorods (GNR) embedded tumor phantom, during photothermal interaction, are reported for plasmonic photothermal therapeutics. Tumor mimicking bilayer phantoms were prepared by using 1% agarose incorporated with 0.1% coffee powder, 0.3% intralipid solution as epidermis layer; 3% intralipid solution and 0.3% human hemoglobin (Hb) powder as dermis layer. On incorporating GNRs of concentrations 10, 20, and 40 μg/ml within the phantom, the absorption coefficients increases 4-8 times, while there is minimal change in the reduced scattering coefficients. Further the absorption coefficient increased by $8% with the incorporation of GNRs of concentration 40 μg/ml, while no considerable dynamic change in the optical properties is observed for the phantom embedded with GNRs of concentrations 10, and 20 μg/ml. The discussed results are useful for the selection of GNRs dose for pre-treatment planning of plasmonic photothermal cancer therapeutics.

show abstract

<title>Temperature dependence of optical properties of in-vivo human skin</title>

Cited by 15 publications

References 0 publications

Development of an Optical Tissue Clearing Laser Probe System

Development of an Optical Tissue Clearing Laser Probe System

Monitoring Blood Glucose Changes in Cutaneous Tissue by Temperature-modulated Localized Reflectance Measurements

Dynamic change in optical properties of a nanoparticle embedded tumor phantom for plasmonic photothermal cancer therapeutics

Contact Info

Product

Resources

About