&lt;title&gt;Semiautomated computerized system for fracture assessment of spinal x-ray films&lt;/title&gt;

Gardner, Jill C.; Heyano, Scott L.; Yaffe, Laurence G.; Ingersleben, Gabriel von; Chestnut, Charles

doi:10.1117/12.237908

Cited by 11 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, most of the measurements used in this study were made with the manual edge location program. Development of more highly automated methods of locating the joint margin, such as the active contour model which has been applied to outlining vertebral bodies, may largely resolve this problem and has high priority in future studies (15,16).…”

Section: Discussionmentioning

confidence: 99%

Computer‐based methods for measuring joint space and estimating erosion volume in the finger and wrist joints of patients with rheumatoid arthritis

Sharp

Gardner

Bennett

2000

Arthritis & Rheumatism

Self Cite

View full text Add to dashboard Cite

Objective. This study was conducted 1) to determine the feasibility of using computer programs to measure radiographic joint space width and estimate erosion volume in the hands of patients with rheumatoid arthritis (RA), and 2) to compare the new computer-based methods with established scoring methods. Methods. To measure the joint space width in the finger and wrist joints of RA patients, hand and wrist radiographic films were scanned using a tabletop scanner and analyzed with programs written using the "macro" capabilities of NIH Image software. Estimation of erosion volume was determined by utilizing gray-scale intensity to calibrate bone density units per mm 3 , which made possible comparisons between the erosions and noneroded, anatomically similar sites. Results. In 3 sets of duplicate measurements of joint space width on 79, 48, and 48 finger and wrist joints, the mean absolute deviation from the mean of the 2 measurements was 0.036 mm (SD 0.034), 0.032 mm (SD 0.049), and 0.021 mm (SD 0.016), respectively. Joint space measurements and scoring of joint space narrowing both demonstrated a difference between active treatment and placebo in an old trial set on gold therapy (P 0.03 and P 0.01, respectively). Two repeated measurements of bone density units in the bones of 3 different hands differed from the mean of the measurement by 2.29-4.04%. In 2 experiments, estimates of erosion volume showed a greater difference between gold therapy and placebo than did erosion scores in the trial set (P 0.049 and P 0.016 versus P 0.27). Conclusion. Computer-based methods for measuring finger and wrist joint spaces and estimating erosion volume in patients with RA agree with the results of radiographic scoring of erosions and joint space narrowing.

show abstract

Section: Discussionmentioning

confidence: 99%

Computer‐based methods for measuring joint space and estimating erosion volume in the finger and wrist joints of patients with rheumatoid arthritis

Sharp

Gardner

Bennett

2000

Arthritis & Rheumatism

Self Cite

View full text Add to dashboard Cite

show abstract

“…Digital image analysis techniques have only recently been used for vertebral morphometry in clinical trials [9,10,17], and they provide a number of advantages, such as the facility to display previously analyzed images with graphic overlays showing fiducial points. Digitizing tablet techniques have previously been widely used for morphometry, and with this technique, fiducial points for height measurements are registered to coordinates on the tablet surface, not coordinates of the image (pixels).…”

Section: Discussionmentioning

confidence: 99%

“…Points are placed on the four 'corners' of a vertebral body in lateral view and up to four points are used for central height measurements, depending on the number of visible endplate contours. Images are displayed using custom software which was developed for vertebral morphometry [10] and are drawn from a large database of digital lateral spine images (n41000) scanned from radiographic film.…”

Section: Methodsmentioning

confidence: 99%

“…Vertebral height measurements obtained with rulers [1][2][3], digitizing tablets [4][5][6][7] and online digital display [8][9][10] have consistently shown intra-and inter-observer precision errors around 2-8%, which persist regardless of measurement technique [11][12][13] and mode of spine image display [8,9,11]. Since incident fracture rates, even in an osteoporotic population, are relatively low (4.0-6.5% in women with existing vertebral deformities [14]), when treatment effects further decrease incidence rates, errors of a few percent in fracture endpoints could potentially affect assessments of treatment efficacy in clinical drug trials in osteoporosis research [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Interactive Tutorial-Based Training Technique for Vertebral Morphometry

Gardner

Ingersleben

Heyano

et al. 2001

Osteoporosis International

View full text Add to dashboard Cite

The purpose of this work was to develop a computer-based procedure for training technologists in vertebral morphometry. The utility of the resulting interactive, tutorial based training method was evaluated in this study. The training program was composed of four steps: (1) review of an online tutorial, (2) review of analyzed spine images, (3) practice in fiducial point placement and (4) testing. During testing, vertebral heights were measured from digital, lateral spine images containing osteoporotic fractures. Inter-observer measurement precision was compared between research technicians, and between technologists and radiologist. The technologists participating in this study had no prior experience in vertebral morphometry. Following completion of the online training program, good inter-observer measurement precision was seen between technologists, showing mean coefficients of variation of 2.33% for anterior, 2.87% for central and 2.65% for posterior vertebral heights. Comparisons between the technicians and radiologist ranged from 2.19% to 3.18%. Slightly better precision values were seen with height measurements compared with height ratios, and with unfractured compared with fractured vertebral bodies. The findings of this study indicate that self-directed, tutorial-based training for spine image analyses is effective, resulting in good inter-observer measurement precision. The interactive tutorial-based approach provides standardized training methods and assures consistency of instructional technique over time.

show abstract

“…In previous work we have described the results of experiments to obtain basic anatomy-referenced orientation within the cervical spine images; in this paper we review our approach to obtaining this anatomy-referenced information, discuss an algorithm (Active Shape Modeling) that may use this information to initialize searches for the boundaries of individual vertebrae of the spine, and present initial results of testing this algorithm on cervical spine images. Successful use of Active Shape Modeling for spine images has been reported by Smyth 2 for the lumbar spine for dual x-ray absorptiometry (DXA) scans, but we are not aware of successful implementations for digitized x-ray film images of the spine, although related work using active contours for digitized spine x-rays has been published (for example, see Gardner 3 ).…”

Section: Introductionmentioning

confidence: 99%

<title>Segmentation and image navigation in digitized spine x rays</title>

Long

Thoma

2000

SPIE Proceedings

View full text Add to dashboard Cite

The National Library of Medicine has archived a collection of 17,000 digitized x-rays of the cervical and lumbar spines. Extensive health information has been collected on the subjects of these x-rays, but no information has been derived from the image contents themselves. We are researching algorithms to segment anatomy in these images and to derive from the segmented data measurements useful for indexing this image set for characteristics important to researchers in rheumatology, bone morphometry, and related areas. Active Shape Modeling is currently being investigated for use in location and boundary definition for the vertebrae in these images.

show abstract

<title>Semiautomated computerized system for fracture assessment of spinal x-ray films</title>

Cited by 11 publications

References 0 publications

Computer‐based methods for measuring joint space and estimating erosion volume in the finger and wrist joints of patients with rheumatoid arthritis

Computer‐based methods for measuring joint space and estimating erosion volume in the finger and wrist joints of patients with rheumatoid arthritis

An Interactive Tutorial-Based Training Technique for Vertebral Morphometry

<title>Segmentation and image navigation in digitized spine x rays</title>

Contact Info

Product

Resources

About