<title>Photosensitizer for PDT based on phosphonate phthalocyanine derivative</title>

Abstract

.ABSTRACT.It is very important to develop new sensitizer which could be efficiently excited at wavelengths exceeding 685 nm where own tissue absorption can be neglected. We have synthesize water soluble phthalocyanine derivative having phosphonate groups as substituents in macrocycle. New sensitizer efficiently absorbs in spectral range 685 -710 nm. It exhibits intense fluorescence in range 690 -720 nm. The photodynamic activity of new sensitizer is higher than in the case of sulfonated aluminium phthalocyanine. BACKGROUND.A wavelength of photosensitizer absorption maximum and, correspondingly, of exciting laser source is one of the most important parameters determing the depth of photodynamic action on tissue. The widely used now haematoporphyrin derivatives (such as "Photofrin", "Photosan", "Photohem")'-3 provide only superficial action (< 4 -S mm) because of strong absorption of unsensitized tissues in spectral range 625 -635 n.m.The widely investigated now phthalocyanine (such as, for example, sulfonated phthalocyanine aluminium4 -PcSA1 ) have in this respect doubtless advantages over haematoporphyrin derivatives. Owing to red shifted PcSA1 long wavelength absorption maximum, the contribution of photosensitizer in absorbance of sensitized tissue begin to predominate offer it's own absorption (Fig. 1). Therefore, it is very important to develop new phthalocyanine derivatives which could be efficiently excited at wavelength exceeding 685 nm where own tissue absorption can be neglected. Fig. 1. The absorption spectra of malignant human tissue (a cheek, basal cell cancer) in vivo in a two hours after injection of PcSA1 (the pointers exhibit the wavelength of excitation of known sensitizers (HpD, PcSA1) and new sensitizer (PcAl). 86 ISPIE Vol. 2924 O-8194-2326-2/96/$6.OO 0,8 0,7 = '' 05 C . 0,2 0,1 0 600 695 650 700 750 Wavelength (nm) Downloaded From: http://proceedings.spiedigitallibrary.org/ on 06/27/2016 Terms of Use: http://spiedigitallibrary.org/ss/TermsOfUse.aspx

Photochemotherapy of experimental colonic tumours with intra-tumorally applied methylene blue

“…The increasing cytotoxicity after the second PDT with these sensitisers may be explained by accumulation of these long acting chemicals. ClAlS 4 Pc, known as a longacting sensitiser in organisms, could not be proved in PDT as reported [28]. The failure of this drug in mice after intravenous application could not be explained.…”

Phthalocyanines and related compounds: XXXVIII. Synthesis of symmetric taurine- and choline-substituted phthalocyanines

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Procedures have been developed for the synthesis of a series of metal complexes derived from water-soluble anionic and cationic octa-4,5-carboxyphthalocyanine3taurine and choline conjugates.Phthalocyanines can be solubilized in water via introduction of sulfo [2], carboxy [3,4], or phosphono groups [5,6] into their molecules. In this way, anionic phthalocyanine dyes are obtained.

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“…Phthalocyanines can be solubilized in water via introduction of sulfo [2], carboxy [3,4], or phosphono groups [5,6] into their molecules. In this way, anionic phthalocyanine dyes are obtained.…”

Hydroxyaluminium Tetra-3-Phenylthiophthalocyanine is a New Effective Photosensitizer for Photodynamic Therapy and Fluorescent Diagnosis

“…The possibility of creating infrared PS based on octabutoxy phthalocyanines with maximum absorption about 750 nm was demonstrated [5]. Phosphinylmethyl-substituted phthalocyanine PS with absorption at 690-740 nm are known [11]. We investigated the possibility of using a new class of substances, phenylthiosubstituted phthalocyanines, as the near infrared band PS.…”