&lt;title&gt;Optoacoustic tomography of breast cancer with arc-array transducer&lt;/title&gt;

Андреев, В. Г.; Karabutov, Alexander A.; Solomatin, Sergey V.; Savateeva, Elena V.; Aleinikov, Vadim; Zhulina, Yulia V.; Fleming, Rachel; Oraevsky, Alexander A.

doi:10.1117/12.386339

Cited by 84 publications

(75 citation statements)

References 5 publications

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“…An advantage inherent in the multiscale wavelet processing is that the wavelet filter simultaneously serves as an integrator, resulting in conversion of bipolar optoacoustic pressure profiles into monopolar profiles of the absorbed optical energy. 35 Three-dimensional tomographic reconstruction was performed using a 3-D reconstruction-algorithm-based radial back projection of filtered and simultaneously integrated optoacoustic signals, 25 where the integration was achieved through a multiscale wavelet transform. 32 Such reconstruction in the 3-D case uses the complete data set and, therefore, is rigorous.…”

Section: Signal Processing and Image Reconstructionmentioning

confidence: 99%

“…Kruger et al successfully developed the first 2-D imaging system and imaged a sacrificed mouse using a commercial linear ultrasound array and rotation motor to generate an optoacoustic slices. 24 As the next-generation device, using the concept of an arc-shaped array previously developed for breast imaging, 25 the same group developed a 3-D system for imaging the whole mouse body. 26 The system showed good spatial resolution and was used to image optical dye phantoms, kidneys, and major vasculature of two sacrificed mice.…”

Section: Introductionmentioning

confidence: 99%

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Whole-body three-dimensional optoacoustic tomography system for small animals

et al. 2009

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Abstract. We develop a system for three-dimensional whole-body optoacoustic tomography of small animals for applications in preclinical research. The tomographic images are obtained while the objects of study ͑phantoms or mice͒ are rotated within a sphere outlined by a concave arc-shaped array of 64 piezocomposite transducers. Two pulsed lasers operating in the near-IR spectral range ͑755 and 1064 nm͒ with an average pulsed energy of about 100 mJ, a repetition rate of 10 Hz, and a pulse duration of 15 to 75 ns are used as optical illumination sources. During the scan, the mouse is illuminated orthogonally to the array with two wide beams of light from a bifurcated fiber bundle. The system is capable of generating images of individual organs and blood vessels through the entire body of a mouse with spatial resolution of ϳ0.5 mm.

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Section: Signal Processing and Image Reconstructionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Whole-body three-dimensional optoacoustic tomography system for small animals

et al. 2009

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“…5 MHz, the minimum detectable pressure (MDP) was not reported [11]. However, for some earlier versions the MDP values have been presented including measured [21] and estimated using only the thermal noise generated by the detector capacitance according to the Nyquist law [19,22].…”

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confidence: 99%

An optimized ultrasound detector for photoacoustic breast tomography

et al. 2013

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15Purpose: Photoacoustic imaging has proven to be able to detect vascularization-driven optical absorption contrast associated with tumors. In order to detect breast tumors located a few centimeter deep in tissue, a sensitive ultrasound detector is of crucial importance for photoacoustic mammography. Further, because the expected photoacoustic frequency bandwidth (a few MHz to tens of kHz) is inversely proportional to the dimensions of light absorbing structures (0.5 to 10+ 20 mm), proper choices of materials and their geometries and proper considerations in design have to be made to implement optimal photoacoustic detectors. In this study, we design and evaluate a specialized ultrasound detector for photoacoustic mammography.Methods: Based on the required detector sensitivity and its frequency response, a selection of active material and matching layers and their geometries is made leading to a functional detector

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“…However, from the technical standpoint, it is better using plane transducers with a focusing acoustic lens [8]. It was shown [3,9] that signal-to-noise ratio and sensitivity increase for such system leading to an improvement of the image contrast.…”

Section: Introductionmentioning

confidence: 99%

“…The section thickness corresponds to the resolution in the direction perpendicular to the image plane and is defined by the design of the transducer array. Low resolution in that direction was the main reason of the decreased quality in the design of all transducer arrays described before [3]. This problem can be solved by using an array of focused transducers [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Wideband focused transducer array for optoacoustic tomography

2009

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Abstract:In this work, a multi-element transducer has been developed for the optoacoustic tomography of biological objects with a given spatial resolution in three dimensions (axial resolution in the image plane was ∆x = 0.1 mm, lateral resolution in the image plane was ∆z = 1.6 mm, lateral resolution in the plane perpendicular to the image plane was ∆y = 0.5 mm). The transducer consists of a set of 8 linear PVDF piezoelectric films (width is 2 mm) located in a plane with 1-mm gap and focused by a cylindrical acoustic lens. Map of the transducer focal area has been experimentally investigated. The resolution ∆y was obtained from the map and is equal to 0.5 mm. Image of a focused point source has been rendered based on experimentally obtained optoacoustic signals. The x-axis resolution and the z-axis resolution were calculated from the focused point source image reconstructed using a back-projection algorithm and are equal to 0.1 mm and 2 mm respectively.

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<title>Optoacoustic tomography of breast cancer with arc-array transducer</title>

Cited by 84 publications

References 5 publications

Whole-body three-dimensional optoacoustic tomography system for small animals

Whole-body three-dimensional optoacoustic tomography system for small animals

An optimized ultrasound detector for photoacoustic breast tomography

Wideband focused transducer array for optoacoustic tomography

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