<title>Optical coherence tomography of the retinal response to ultrashort laser pulses</title>

Abstract

Purpose: To assess the early in vivo evolution of tissue response and wound healing from ultrashort pulsed laser retinal lesions by correlating the cross sectional morphology from sequential optical coherence tomography with histopathologic sectioning. Methods: Single ultrashort laser pulses (20-40 1.tJ, 580 nm 3 picosecond) were placed in the Macacca mulatta retina and evaluated by cross-section optical coherence tomography (OCT). These images were compared at selected time-points with corresponding histological sections. Results: OCT was able to detect the acute tissue injury from laser delivery and the evolution of the healing response over 8 days after laser delivery. These OCT images correlated well with histopathologic findings. Conclusion: Analysis of the extent of initial laser lesions and the type of healing response can be performed in serial sequence with OCT providing new insight into the healing response from laser injury. This information correlates well with light microscopic data.

Imaging engineered tissues using structural and functional optical coherence tomography

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Use of White Light Interference Methods in the Opaque Mediums Diagnostic

“…The clinical material acquired fully confirmed the enormous usefulness of this technique in imagining of an eyeball rear section. Currently, the OCT tomogram analysis results in many retina affections may be treated as decided [4][5][6].…”