<title>Novel approach to multichannel SPR sensing</title>

Abstract

A novel approach to multichannel SPR sensing based on encoding information from separate sensing channels into a single optical spectrum is presented. A dual channel SPR sensor using this approach is demonstrated. Attention is given to exploitation of the dual-channel SPR sensor for compensation for background interference and non-specific adsorption of the biomolecules to the surface of the SPR biosensor. Experimental results indicate that background refractive index changes were compensated with accuracy better than 8x1ff5 RIU (refractive index unit); the effect of a temperature change of 3.6 K was reduced by a factor of 13 by the dual-channel sensor. SPR biosensor-based detection of monoclonal anti-dinitrophenyl antibody (a-DNP) with compensation for non-specific adsorption is demonstrated.

Data analysis for optical sensors based on spectroscopy of surface plasmons

“…The tracking algorithm provides a general method for tracking arbitrary resonance features. For instance, it has been used to track multiple resonances within the same spectrum simultaneously [11][12][13].…”