<title>Influence of multiple light-scattering on TiO2 nanoparticles imbedded into stratum corneum on light transmittance in UV and visible wavelength regions</title>

Abstract

This paper focuses on the simulation of propagation of radiation in UV and visible wavelength regions within a superficial skin layer (stratum corneum, SC) partially filled with titanium dioxide (TiO 2 ) nanoparticles. Volume concentrations of the particles (0.67% -2.25%) correspond to the maximal concentrations of the considered particles in the frames of independent scattering. Transmittance of 307-, 400-, and 500-nm light through a 20-µm thick SC is calculated. The effect of the TiO 2 nanoparticles on the contribution of photons undergone different numbers of scattering acts into transmittance is considered. It is shown that administration of the nanoparticles results in the broadening of the distribution of transmitted photons over undergone scattering acts. It also results in the shift of the maximum location of this distribution to larger number of scattering acts for the wavelengths of 400 and 500 nm being the latter the most pronounced. The increase of undergone scattering acts leads to the elongation of photon trajectories within the medium and results in the increase of the diffuse reflected light and the transmittance decrease.