&lt;title&gt;Immunosensor-based drug detectors for customs and other operations&lt;/title&gt;

Shrivastava, Paul; Mclean, Christopher J.; Aberl, Franz; Bonenberger, Johannes; Berg, R.P. van den; Zimmermann, Rudolph

doi:10.1117/12.266772

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2015

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“…Alternative methods include ion-mobility spectrometry [7,22], electrochemiluminescence [23], and Raman microspectroscopy [9]. The immunodetection of cocaine on banknotes is limited to the application of strip-based immunoassays originally developed for qualitative detection of the drug in urine [24,25]. The detection of cocaine extracted from doped fingerprints is similarly focused on MS-based approaches, such as desorption electrospray ionization (DESI)-MS [15] and SALDI-TOF-MS [16] or Raman spectroscopy [14,17].…”

Section: Introductionmentioning

confidence: 99%

A competitive enzyme immunoassay for the quantitative detection of cocaine from banknotes and latent fingermarks

Heide

Calavia

Hardwick

et al. 2015

Forensic Science International

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A sensitive and versatile competitive enzyme immunoassay (cEIA) has been developed for the quantitative detection of cocaine in complex forensic samples. Polyclonal anti-cocaine antibody was purified from serum and deposited onto microtiter plates. The concentration of the cocaine antibody adsorbed onto the plates, and the dilution of the cocaine-HRP hapten were both studied to achieve an optimised immunoassay. The method was successfully used to quantify cocaine in extracts taken from both paper currency and latent fingermarks. presents a simple and cost-effective alternative to the current mass spectrometry based techniques for the quantitation of cocaine at forensically significant concentrations.

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