<title>CVSys: a coordination framework for dynamic and fully distributed cardiovascular modeling and simulation</title>

Abstract

This paper presents a new framework, CVSys, for dynamic and fully distributed cardiovascular simulation with natural behavior flow and dynamic simulation control. This coordination framework uniquely incorporates attributes of open-endedness in terms of dynamic interactive entry of changing states during runtime, flexibility of event handling and system extensibility. The coordination framework relies on the autonomous object paradigm underlying a new distributed computing environment, MESSENGERS 1 .CVSys exploits extensive parallelism found in physiological processes. Natural behavior flow is the guiding principle of design and development, closely coupling model and compute processes to actual physical entity flow patterns, resulting in a more indigenous and a more integrated system representation. Dynamic simulation control serves to interject new events or state changes into the simulation in a random and dynamic method during runtime without halting execution and under fully distributed control. We distinguish two types of dynamic simulation control, Reflex arc network activated internally at receptor sites from detected state changes, and Simulation steering activated in response to externally introduced events. The CVSys Coordination Framework including natural behavior flow and dynamic simulation control features enable a more expressive cardiovascular modeling system. Also noteworthy is the representation of regional circulatory beds with related short term response adaptations, handled in a fully distributed and dynamic approach. Advancement of the current state of cardiovascular simulation is found in CVSys, realized through the introduction of new distributed and parallel computing methods.

Modeling the Dynamics of the Cardiovascular-respiratory System (CVRS) in Humans, a Survey

“…Of course, most of the goals listed in the following have also implications for model based diagnostic procedures. In this context we want to draw attention to [85], [55].…”