<title>Clinical trials of a new chlorin photosensitizer for photodynamic therapy of malignant tumors</title>

Photodynamic effect of novel chlorin e6 derivatives on a single nerve cell

“…4b). Radachlorin has been recently shown to be a promising PDT sensitizer (Privalov et al, 2002). Its main active component purpurin 5 is hydrophobic.…”

“…Introduction of hydrophilic groups imparts chlorin e 6 molecules with amphiphilicity and, therefore, with good solubility in both polar and non-polar media. Such properties provide some chlorin e 6 derivatives with good tumor/tissue ratio, high anti-tumor efficacy, and rather short (48 h) clearance time (Privalov et al, 2002).…”

Photodynamic Effects of Radachlorin® on Cervical Cancer Cells

“…Ⓡ has recently been shown to be a promising PDT sensitizer (23), with a report showing the photodynamic effect on novel chlorin e6 derivatives, including Radachlorin Ⓡ , on a single nerve cell (24). The study demonstrated that Radachlorin Ⓡ was a most potent photosensitizer, comparable with Meso-[tetrakis(m-hydroxyphenyl)]chlorin (mTHPC), a well-known photosensitizer (24).…”

“…The highest contrast with Radachlorin Ⓡ was observed at 18 h after the intraperitoneal administration with the tumor-to-muscle ratio of about 32, and tumor-to-skin ratio of about 44. The full clearance period was been found to be 48 h after the intraperitoneal administration via all routes of administration, a very important point as regards the problem of skin phototoxicity (23). Therefore, Radachlorin Ⓡ shows excellent characteristics for use with PDT (21).…”

Люминесценция водного раствора фотосенсибилизатора Радахлорин при возбуждении в полосах 405 и 605 nm

“…Различные свойства Радахлорина исследуются уже более 10 лет [6], однако большинство этих исследований было посвящено его клиническим испытаниям [7][8][9][10]. Радахлорин имеет несколько полос поглощения, наиболее важными из которых являются полосы с максимумами на 405 и 660 nm, положения которых незначительно изменяются в зависимости от типа растворителя, pH среды и концен-трации ФС [11,12].…”