⁹⁹Mo/^99mTc-¹¹³Sn/^113mIn Dual Radioisotope Generator Based on 6-Tungstocerate(IV) Column Matrix

Abstract

Elutions of 99m Tc and 113m In have been performed subsequently with 10 mL of 0.9% NaCl solution and 10 mL of 0.1 M HCl solution, respectively, from 6-tungstocerate(IV) chromatographic column loaded with 0.54 MBq 99 Mo and 0.45 MBq 113 Sn, using alumina-column filter in the case of 99m Tc. Radionuclidic purity of both eluates was ≥ 99.99%. Elution yields of 72.5±5.8% and 62.2±3.7%, and radiochemical purities of 96.9±1.0% (as 99m TcO 4-) and 88.4±2.5% (as 113m In 3+) have been obtained for 99m Tc and 113m In, respectively. Al and W impurities in the 99m Tc and 113m In eluates, respectively, were found to be within the accepted limits, whereas no Ce impurities were detected in both eluates. Also trials have been carried out on a similar system to obtain mixed 99m Tc-113m In eluates from 6tungstocerate column with different 99m Tc/ 113m In ratios using 0.9% NaCl-HCl eluents of different pH values. To separate 99m Tc and 113m In from each other, these mixed eluates were passed through a column of hydrous zirconium oxide which was then eluted with 10 mL of 0.9% NaCl solution and 15 mL of 0.1 M HCl solution, respectively. No W, Ce, or Zr impurities were detected in the 99m Tc and 113m In eluates obtained in these trials.

Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate

“…Although ( , ) 99 Mo has a lower specific activity (< 10 Ci/g) [8], it has many advantages where simple equipment is needed for processing, radionuclidic contamination is limited by the target purity (especially for 98 Mo enriched targets) and the produced radioactive waste is minimal. [4] or secondly by incorporation of Mo into gel materials [e. g., 12-molybdocerate, 6-tungstocerate, stannic molybdate, titanium molybdate, zirconium molybdate, zirconium molybdophosphate, alumina molybdate, cerium(IV) molybdate, cerium(IV) tellurium molybdate] via precipitation reactions using the post-irradiation method or the less-common pre-irradiation method [9][10][11][12][13][14][15][16][17], (ii) Extraction generators including solvent extraction (conventional or aqueous biphasic system), solid phase extraction generators, extraction chromatographic generators and supported liquid membrane generators (as a modified version of extraction chromatography) (iii) sublimation and thermochromatographic generators and (iv) electrochemical generators [4].…”

Preparation and characterization of cerium(IV) tellurium molybdate gel and its application as a bed for chromatographic ⁹⁹Mo/^99mTc generator

“…1 Criteria for good gel generators include high-content of 99 Mo in the gel bed, highelution yield and high radionuclidic, radiochemical and chemical purities of the 99m Tc eluates. Many gel materials, including acidic salts of polyvalent metals and salts of heteropolyacids, have been used as beds for 99 Mo/ 99m Tc generators, e.g., zirconium molybdate, [2][3][4][5][6] stannic molybdate, 7 titanium molybdate, 8 cer ium (I V) molybdate, 9 12-molybdocerate (I V), 10 6tungstocerate(IV) 11 magnesium molybdate 12 and zirconium molybdophosphate. 13 Zirconium molybdate is the most famous material used as a bed for 99 Mo/ 99m Tc generators, but the synthesis and study of other gel materials constitute a renewable research filed in literature to obtain more alternatives.…”