&lt;sup&gt;75&lt;/sup&gt;Se-Selenomethionine Excretion in Bile and Pancreatic Juice

Pointner, H; Kinast, H.; Flegel, U

doi:10.1159/000197655

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The protein‐bound radioactivity in the duodenal aspirates is used as an index of pancreatic exocrine function. Some studies reported a good separation of healthy controls and patients with chronic pancreatitis, 82 , 83 whereas more recent studies failed to show a sufficient sensitivity for this test 84–86 . The sensitivity and specificity of this test are both considerably less than those of the secretin–cholecystokinin stimulation test, despite being an equally invasive procedure requiring duodenal intubation and exposure to radioactive substances 4 …”

Section: Direct Tests Of Pancreatic Synthetic Capacitymentioning

confidence: 99%

Pancreatic function testing

Chowdhury

Forsmark

2003

Aliment Pharmacol Ther

189

122

View full text Add to dashboard Cite

SUMMARYPancreatic function tests are most commonly used to diagnose chronic pancreatitis. These tests include tests which document exocrine or endocrine gland insufficiency and tests which instead measure gradations of decreased secretory capacity. The tests in the former category generally become abnormal when advanced, longstanding chronic pancreatitis is present. Tests in the latter category, however, have the potential to detect chronic pancreatitis at an earlier stage than other available diagnostic tests, including commonly used imaging tests such as computed tomography and endoscopic retrograde cholangiopancreatography. This potential advantage of diagnostic sensitivity is, however, counterweighed by the fact that these tests which measure stimulated secretory capacity are only available at a very few referral centres. This article will review the variety of pancreatic function tests and describe their rationale, accuracy, cost, and clinical usefulness.

show abstract

Section: Direct Tests Of Pancreatic Synthetic Capacitymentioning

confidence: 99%

Pancreatic function testing

Chowdhury

Forsmark

2003

Aliment Pharmacol Ther

189

122

View full text Add to dashboard Cite

show abstract

“…From previous results with thin-layer chromatography technique (19) and from theoretical consideration we had ex pected that in pancreatic insufficient subjects 75Se-/-Selenomethionine in Pancreatic Disease less 75Se-/-selenometliionine would be incorpo rated into pancreatic enzymes and so the first peak on gel filtration would be distinctly smaller than in normal subjects. We could not find any significant differences between the two groups on the gel filtration pattern whatev er ratio or correlation we tried to establish.…”

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 96%

“…This is valid both in man and in animals (17,19). A further study, based on thin-layer chromatography (19), suggested that the 75Se-/-selenomethionine method could probably be of diagnostic value for pancreatic disease, when duodenal juice is further treated by chromatographic methods. On the other hand, Shichiri et al (20) reported on good results in the assessment of pancreatic exocrine function when measuring the trichlo roacetic acid (TCA)-precipitable fraction of duodenal juice.…”

mentioning

confidence: 96%

See 1 more Smart Citation

Evaluation of the <sup>75</sup>Se-<i>l</i>-Selenomethionine Test for Pancreatic Disease

Pointner¹,

Kletter²

1980

Digestion

Self Cite

View full text Add to dashboard Cite

Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 50–100 μCi ⁷⁵Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) for 2 h. Duodenal juice was collected from a double-lumen Lagerlöf tube and the ⁷⁵Se radioactivity measured. Gel filtrations on Sephadex G-50 were performed from samples of duodenal juice. Total duodenal radioactivity in pancreatic insufficient patients was significantly lower than in normal subjects 60–120 min after the start of the examination. When regarding the individual values of each subject an important overlap of normal and pancreatic insufficient persons could be observed. No difference in the gel filtration pattern was demonstrable between the two groups. From these results the use of ⁷⁵Se-l-selenomethionine for diagnostic purposes in pancreatic diseases cannot be recommended.

show abstract