¹⁸F-fludrodeoxyglucose maximal standardized uptake value and metabolic tumor burden are associated with major chemotherapy-related tumor markers in NSCLC patients

Abstract

ObjectiveMetabolic activity and tumor burden are significant for prognosis and metastasis of non-small cell lung cancer (NSCLC), including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Chemotherapy resistance is a great challenge for treating NSCLC patients and is also closely related with several biomarkers such as epidermal growth factor receptor (EGFR), p53, and excision repair cross-complementing group 1 protein (ERCC1). Our purpose was to determine the correlation between positron emission tomography/computed tomography (PET/CT) parameters and tumor markers-related chemotherapy resistance in NSCLC.MethodsForty-six NSCLC chemotherapy-naïve patients were enrolled. The SUVmax, MTV, and TLG were calculated by PET/CT imaging, and expression of EGFR, p53, and ERCC1 were analyzed by immunohistochemistry on tissues. SUVmax, MTV, and TLG compared for their performance in predicting the expression of EGFR, p53, and ERCC1 were illustrated with statistical analysis.ResultsSUVmax was significantly correlated with p53 expression (P=0.001), and MTV and TLG were significantly associated with ERCC1 (P=0.000; P=0.000). Furthermore, multiple stepwise regression analysis revealed that SUVmax was the primary predictor for p53, MTV and TLG was the primary predictor for ERCC1. SUVmax had a sensitivity of 91% and specificity of 50% for the detection of p53 positive. The sensitivities of MTV and TLG were 83% and 80%, and specificities were 69% and 75% for the detection of ERCC1 positive, respectively. When we suggested p53 or ERCC1 positive, the cutoff value of SUVmax, MTV, and TLG were 7.68, 23.62, and 129.65 cm3, respectively.ConclusionSUVmax, MTV, and TLG were closely associated with p53 and ERCC1’ expressions. Therefore, 18F-fludrodeoxyglucose PET/CT could be a new way of predicting p53 or ERCC1-related chemotherapy effect in NSCLC patients with more convenience.

Standardized Uptake Values Derived from18F-FDG PET May Predict Lung Cancer Microvessel Density and Expression of KI 67, VEGF, and HIF-1αbut Not Expression of Cyclin D1, PCNA, EGFR, PD L1, and p53

“…There were 5 studies (409 patients) which investigated associations between 18 F-FDG PET and expression of EGFR in lung cancer [ 13 , 34 , 38 , 42 , 44 ]. The reported correlation coefficients ranged from 0.04 to 0.83 ( Figure 9 ).…”

Prognostic value of 18F-FDG PET /CT metabolic parameters in patients with locally advanced pancreatic Cancer treated with stereotactic body radiation therapy

“…Thus, MTV and TLG could provide a more accurate prognostic value. In recent stuides, TLG was considered as a much better indicator than MTV in prognosis evaluation [17]. It is conceptual understandable that TLG gained favour.…”

Combined prognostic value of the SUVmax derived from FDG-PET and the lymphocyte-monocyte ratio in patients with stage IIIB-IV non-small cell lung cancer receiving chemotherapy

“…In addition, we also demonstrated that a high SUVmax was a significant predictive marker of poor chemotherapeutic response. The mechanism may be related to the overexpression of p53 in tumor cells, as a previous study confirmed the positive correlation between SUVmax and p53 expression [30], and p53 overexpression has been proved to be significantly correlated with chemotherapy resistance in lung cancer [31]. This may Accumulating evidence has demonstrated that systemic inflammation plays a key role in tumorigenesis, progression and metastasis [17].…”