&lt;sup&gt;13&lt;/sup&gt;C-Urea Breath Test Accuracy for
                        &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection in the Asian Population: A
                        Meta-Analysis

Rahim, Muhammad Aklil Abd; Johani, Fadzrul Hafiz; Shah, Shamsul Azhar; Hassan, Mohd Rohaizat; Manaf, Mohd Rizal Abdul

doi:10.5334/aogh.2570

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…The high accuracy of 13 C-UBT was also confirmed in a meta-analysis, including 15 studies performed in Asia. The sensitivity and specificity results were excellent, notwithstanding the heterogeneity observed across all studies [ 54 ].…”

Section: Non-invasive Testsmentioning

confidence: 99%

What Is New in Helicobacter pylori Diagnosis. An Overview

Dore

2021

JCM

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Helicobacter pylori infection remains one of the most prevalent infections worldwide, especially in low-resource countries, and the major risk factor for peptic ulcer and gastric cancer. The “test-and-treat” strategy is recommended by several guidelines and consensus. The choice of testing method is based on patient age, presence of alarm signs and/or symptoms, use of non-steroidal anti-inflammatory drugs, as well as local availability, test reliability, and cost. Culture is the gold standard to detect H. pylori and, possibly, to perform susceptibility testing, however, it requires upper endoscopy and dedicated labs. Recent advances in molecular biology have provided new strategies in detecting infection and antimicrobial resistance without invasive tests. In this review we attempt to offer a comprehensive panorama on the new diagnostic tools and their potential use in clinical settings, in order to accomplish specific recommendations.

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Section: Non-invasive Testsmentioning

confidence: 99%

What Is New in Helicobacter pylori Diagnosis. An Overview

Dore

2021

JCM

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“…There might be a possibility that false-negative post-WMT UBT results were obtained in some patients. However, 13 C-UBT has been used in clinical practice as a standard method to determine H. pylori status after H. pylori eradication therapy, due to its high sensitivity and specificity [ 42 – 44 ]. Thus, it is unlikely that the false-negative results 13 C-UBT occurred in nearly 30% of cases after WMT.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study

Xia

Zhang

et al. 2020

Gastroenterology Research and Practice

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Aim. The fecal microbiota transplantation by washed preparation was recently coined as washed microbiota transplantation (WMT). This pilot study is aimed at exploring the feasibility and efficacy of WMT on Helicobacter pylori eradication. Methods. Consecutive patients who had been treated with WMT for various indications and who were positive for H. pylori infection before WMT treatment but had never received eradication therapy for H. pylori infection were invited to take a follow-up 13C-urea breath test. The associations of demographic, clinical factors, and laboratory indicators for gastric function and intestinal barrier function with the therapeutic effect were determined. Results. A total of 32 eligible patients were included, and the overall H. pylori eradication rate was 40.6% (13/32). Patients with H. pylori eradication had a higher pepsinogen ratio (PGR) than those without ( 13.00 ± 6.97 vs. 8.31 ± 3.733 ; P = 0.02 ). Female patients had a higher, albeit not statistically significant, eradication rate than male patients (53.85% vs. 31.58%; P = 0.208 ). Compared with lower gastrointestinal tract delivery route, middle gastrointestinal tract delivery route seems to be a more suitable way for the treatment of H. pylori infection (58.33% vs 16.67%; P = 0.152 ). There was no significant difference in other demographic and clinical factors between patients with and without H. pylori eradication. Conclusion. H. pylori infection is eradicated in a proportion of patients who have received WMT. An increased pre-WMT PGR appears to be associated with the therapeutic effect. Further studies are required to confirm the efficacy of WMT, especially in combination with currently recommended regimens in randomized controlled trials.

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“…Finally, a meta‐analysis by Abd Rahim et al, reported the different 13 C‐UBT accuracy studies conducted in Asia 32 . In total, 15 protocols were referenced and analysed by the authors.…”

Section: Non‐invasive Testsmentioning

confidence: 99%

Review: Diagnosis of Helicobacter pylori infection

2020

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New endoscopic techniques, especially linked colour imaging (LCI) and blue laser imaging (BLI), were extensively evaluated this year either for the diagnosis of Helicobacter pylori gastritis or the detection of early gastric cancer (EGC). In the first case, the studies followed a similar protocol. Endoscopy was performed with the new imaging technique as well as white light imaging (WLI) on a group of patients for whom the H pylori status was established by various methods. Several images were obtained from different parts of the stomach and submitted blindly to a group of endoscopists (at least 4) for evaluation. The first aim was to determine the sensitivity and specificity of the new method vs WLI. LCI always performed better than WLI with sensitivity and specificity for LCI ranging from 83.8% to 85.4% and 79.5% to 99.5%, respectively (Table 1). The difficulty stemmed from the fact that there are different stages of H pylori gastritis, from active inflammation to atrophy and intestinal metaplasia, which exhibit very different aspects. Nevertheless in their study, Wang et al concluded that identification of H pylori gastritis by LCI was especially reliable in the corpus. 1 In another study by Jiang et al, using a score of 3.5 as the cutoff value, sensitivity and specificity were 83.8% and 99.5%, respectively, for the diagnosis of H pylori gastritis among 358 patients. 2 Ono et al 3

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<sup>13</sup>C-Urea Breath Test Accuracy for <i>Helicobacter pylori</i> Infection in the Asian Population: A Meta-Analysis

Cited by 19 publications

References 29 publications

What Is New in Helicobacter pylori Diagnosis. An Overview

What Is New in Helicobacter pylori Diagnosis. An Overview

The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study

Review: Diagnosis of Helicobacter pylori infection

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